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Abstract

ABSTRACT:The purpose of this study was to investigate the effects of the Ramadan fasting and life rhythm eating rhythm on some elimination parameters, such as the antipyrine clearance, urinary volume and pH. A single oral dose of Antipyrine was administred to 14 healthy volunteers at 08:00 p.m. All the volunteers were submitted to four treatment phases; the first one was carried out 1 week prior to Ramadan (PR), the second on the first week of Ramadan (R1), the third on the third week of Ramadan (R3) and the last one 3 weeks after Ramadan (AR). The salivary kinetic of antipyrine was determined for each treatment throughout the 48 hours following drug intake. Eight urine collections were performed after each antipyrine intake, their volumes and pH were immediately determined. Saliva antipyrine concentrations were determined by high-pressure liquid chromatography (HPLC). No significant differences were found in salivary antipyrine elimination half-life t1/2 and clearance between the four periods studied. The 24 hours urine volume was not significantly modified during Ramadan. However, its circadian variations showed a significant increase during the night (F = 4,046, p < 0,05) and a significant decrease in the afternoon (F = 3,245 , p < 0,05) during Ramadan. The urine pH is significantly influenced by the data collection time and also by Ramadan with (F = 3, 1789, p < 0,05) and (F = 18,3133, p < 0,0001), respectively. INTRODUCTION:Despite the importance of the problem which concerns millions of people throughout the world, physiological and clinical studies on Ramadan fasting remain relatively rare. It is, thus, difficult to suggest a rational therapeutic behavior able to address both fasting and therapeutic goals.