The effect of pH on the synthesis of stable Cu2O/CuO nanoparticles by sol–gel method in a glycolic medium

Zayyoun, N.; Bahmad, L.; Laânab, L.; Jaber, B.

doi:10.1007/s00339-016-0024-9

Cited by 79 publications

(30 citation statements)

References 30 publications

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“…While Ce-O stretching bond frequencies were found at 453 cm -1 . Corresponding findings related to Cu-O and Ce-O are well indexed to previously reported studies ( Zayyoun et al, 2016 ; Maqbool, 2017 ).…”

Section: Discussionsupporting

confidence: 91%

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

et al. 2018

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One of the major challenges of nano-biotechnology is to engineer potent antimicrobial nanostructures (NS) with high biocompatibility. Keeping this in view, we have performed aqueous olive leaf extract mediated one pot facile synthesis of CuO-NS and CeO2-NS. Prepared NS were homogenous, less than 26 nm in size, and small crystallite units as revealed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses. Fourier transform infrared spectroscopy (FTIR) of CuO-NS and CeO2-NS showed typical Cu-O prints around 592–660 cm-1 and Ce-O bond vibrations at 453 cm-1. The successful capping of CuO-NS and CeO2-NS by compounds present in the plant extract was further validated by high performance liquid chromatography (HPLC) and thermal gravimetric analysis (TGA). Active phyto-chemicals from the leaf extract simultaneously acted as strong reducing as well as capping agent in the NS synthesis. NS engineered in the present study showed antibacterial potential at extremely low concentration against highly virulent multidrug-resistant (MDR) gram-negative strains (Escherichia coli, Enterobacter cloacae, Acinetobacter baumannii and Pseudomonas aeruginosa), alarmed by World Health Organization (WHO). Furthermore, CuO-NS and CeO2-NS did not show any cytotoxicity on HEK-293 cell lines and Brine shrimp larvae indicating that the NS green synthesized in the present study are biocompatible.

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Section: Discussionsupporting

confidence: 91%

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

et al. 2018

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“…32,33 It is well documented that the gallic acid is present as one of the key phenolic components in M. charantia fruit extract which might facilitate the reduction of Cu(OH) 2 to nano-sized CuO. 34 During the reaction, when pH is increased in the range of 11, the color of reaction changes from blue to brown and then to black. 35 The changes in the color may be understood in terms of the reaction between copper (II) sulfate pentahydrate and sodium hydroxide to form copper (II) hydroxide (blue), which in turn reacts with the gallic acid resulting in the formation of dehydrogallic acid and copper (I) oxide(brown).…”

Section: Results and Discussion Green Synthesis Of Cuo Nrs And Uv-vismentioning

confidence: 99%

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

Qamar¹,

Rehman²,

Chauhan³

et al. 2020

IJN

105

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Background: In the emerging field of nanotechnology, copper oxide (CuO) nanomaterials are considered to be one of the most important transition metal oxides owing to its fascinating properties. Its synthesis from green chemistry principles is gaining importance as next-generation antibiotics due to its simplicity, eco-friendliness, and cost-effectiveness. In the present study, CuO nanorods (CuO NRs) were synthesized from the aqueous fruit extract of Momordica charantia and characterized using different analytical techniques. Further, the biomedical therapeutic potential was evaluated against multi-drug resistant microbial strains. Materials and Methods: To synthesize CuO NRs, 0.1M of CuSO 4 .5H 2 O solution was added to aqueous extract of Momordica charantia in a 1:3 (v/v) ratio (pH=11) and heated at 50°C followed by washing and drying. The synthesized CuO NRs were subjected to characterization using different analytical techniques such as UV visible spectroscopy, zeta sizer equipped with zeta potential, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) equipped with energydispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). Further, the application as a biomedical therapeutic potential was evaluated in vitro using well diffusion method against eleven multidrug-resistant clinical bacterial strains, a fungus-Trichophyton rubrum and in ovo against the R 2 B virus using haemagglutination (HA) test. Results: Characterization was preliminarily done by the spectral study that confirms the absorbance band at 245nm. FTIR analysis at 628 cm −1 peak identified copper oxide vibration. SEM analysis revealed agglomerated particle clusters. However, with TEM clear nanorods of average diameter of 61.48 ± 2 nm were observed. EDAX confirmed CuO formation while XRD showed a typical monoclinic structure with 6 nm crystallite size. Biological screening of CuO NRs showed significant results against both in vitro and in ovo methods. Significant inhibitory activity (p<0.0001) was noted against most of the resistant human pathogenic strains including both Gram-positive and Gram-negative bacteria. The highest efficacy was observed against Bacillus cereus with a 31.66 mm zone of inhibition. Besides, the therapeutic potential of CuO NRs against Corynebacterium xerosis, Streptococcus viridians and R 2 B strain of Newcastle disease is reported for the first time.Conclusion: Based on the present results, it could be expected that green synthesized CuO NRs would find potential applications in the field of nanomedicine.

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“…All previously reported methods for the synthesis of Cu 2 O particles have required heating of the solution (eg, hydrothermal, polyol, and glucose‐reduction methods). Cu 2 O particles on high‐surface area substrates were prepared by mechanical mixing of solution‐route synthesized Cu 2 O particles and silica gel or the heat treatment of copper‐based precursor supported silica .…”

Section: Discussionmentioning

confidence: 99%

“…This is because the major oxidation states of Cu are Cu 4 O 3 , Cu 2 O, and CuO, while the Cu 2+ state is considered to be more stable than the Cu + state . The syntheses reported for the production of Cu 2 O are the hydrothermal, polyol, or glucose‐reduction methods, where the oxidation states of Cu are controlled with multiple steps to adjust the pH of the solvent, the amount of reducing agent, and the reduction rate …”

Section: Introductionmentioning

confidence: 99%

Formation mechanism of Cu₂O particles using layered CaSi₂ as a reduction/oxidation mediator

Itahara¹,

Nakano²

2019

J Am Ceram Soc

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We demonstrate that Cu2O particles can be produced along with siloxene formation by simply dispersing layered CaSi2 into an aqueous solution of CuCl2 and HCl at room temperature. The Cl− ions induce oxidative extraction of Ca from CaSi2 to form siloxene and trigger the reductive deposition of Cu particles. All particles are then gradually oxidized to form Cu2O particles under optimized conditions as follows. A trace amount of residual CaSi2 is dissolved in the solution, which provides OH− ions, and a portion of the formed Cu particles are dissolved as [Cu(OH)4]2− ions. Accordingly, Cu2O particles would be formed through the comproportionation reaction between Cu and [Cu(OH)4]2− ions in the solution. However, under conditions with an excess amount of Cl− ions results in further oxidation of Cu to also form Cu2Cl(OH)3. Thus, CaSi2 acts as an effective reduction and/or oxidation mediator to tune the number of Cl− and OH− ions and control the oxidation state of Cu.

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The effect of pH on the synthesis of stable Cu2O/CuO nanoparticles by sol–gel method in a glycolic medium

Cited by 79 publications

References 30 publications

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

Formation mechanism of Cu₂O particles using layered CaSi₂ as a reduction/oxidation mediator

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The effect of pH on the synthesis of stable Cu2O/CuO nanoparticles by sol–gel method in a glycolic medium

Cited by 79 publications

References 30 publications

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

<p>Green Synthesis, Characterization and Antimicrobial Activity of Copper Oxide Nanomaterial Derived from <em>Momordica charantia</em></p>

Formation mechanism of Cu2O particles using layered CaSi2 as a reduction/oxidation mediator

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Formation mechanism of Cu₂O particles using layered CaSi₂ as a reduction/oxidation mediator