The effect of periodontal bacteria infection on incidence and prognosis of cancer

Li, Xiao; Zhang, Qianyu; Peng, Yanshuang; Wang, Daqing; Liu, Ying

doi:10.1097/md.0000000000019698

Cited by 38 publications

(33 citation statements)

References 52 publications

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“…The results of that meta-analysis indicated that periodontal bacterial infection increased cancer incidence and was associated with poor overall survival, diseasefree survival, and cancer-specific survival. Subgroup analysis indicated that the risk of cancer was associated with Porphyromonas gingivalis and Prevotella intermedia infection but not Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans, and F. nucleatum infection (60).…”

Section: The Oral Microbiome and Cancermentioning

confidence: 92%

“…In the case of breast cancer, the evidence shows a more modest positive association between periodontal disease and breast cancer (61). Finally, the most expected correlation would be with oral cancers, and indeed there is a clear positive correlation between periodontal disease and oral cancers (55,59,60). Edentulism has been positively correlated with pancreatic cancer (58) but not within colorectal cancer (62).…”

Section: The Oral Microbiome and Cancermentioning

confidence: 99%

“…Never smokers population with periodontal disease has a higher risk of developing hematopoietic and lymphatic cancers (55,56). Pancreatic, lung, and colorectal cancers also show a positive correlation with periodontal disease (55,(57)(58)(59)(60). In the case of breast cancer, the evidence shows a more modest positive association between periodontal disease and breast cancer (61).…”

Section: The Oral Microbiome and Cancermentioning

confidence: 99%

“…Interestingly, in the study where authors did not find associations of edentulism and colorectal cancer (CRC), they also found no correlation between edentulism and periodontitis (62). One of these meta-analyses looked at not only a correlation between periodontal disease and cancer but also correlations with particular organisms (60). The results of that meta-analysis indicated that periodontal bacterial infection increased cancer incidence and was associated with poor overall survival, diseasefree survival, and cancer-specific survival.…”

Section: The Oral Microbiome and Cancermentioning

confidence: 99%

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The Oral Microbiome and Cancer

2020

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There is mounting evidence that members of the human microbiome are highly associated with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied, and it is the most common malignancy of the head and neck worldwide. However, there is a void regarding the role that the oral microbiome may play in OSCC. Previous studies have not consistently found a characteristic oral microbiome composition associated with OSCC. Although a direct causality has not been proven, individual members of the oral microbiome are capable of promoting various tumorigenic functions related to cancer development. Two prominent oral pathogens, Porphyromonas gingivalis, and Fusobacterium nucleatum can promote tumor progression in mice. P. gingivalis infection has been associated with oro-digestive cancer, increased oral cancer invasion, and proliferation of oral cancer stem cells. The microbiome can influence the evolution of the disease by directly interacting with the human body and significantly altering the response and toxicity to various forms of cancer therapy. Recent studies have shown an association of certain phylogenetic groups with the immunotherapy treatment outcomes of certain tumors. On the other side of the coin, recently it has been a resurgence in interest on the potential use of bacteria to cure cancer. These kinds of treatments were used in the late nineteenth and early twentieth centuries as the first line of defense against cancer in some hospitals but later displaced by other types of treatments such as radiotherapy. Currently, organisms such as Salmonella typhimurium and Clostridium spp. have been used for targeted strategies as potential vectors to treat cancer. In this review, we briefly summarize our current knowledge of the role of the oral microbiome, focusing on its bacterial fraction, in cancer in general and in OSCC more precisely, and a brief description of the potential use of bacteria to target tumors.

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Section: The Oral Microbiome and Cancermentioning

confidence: 92%

Section: The Oral Microbiome and Cancermentioning

confidence: 99%

Section: The Oral Microbiome and Cancermentioning

confidence: 99%

Section: The Oral Microbiome and Cancermentioning

confidence: 99%

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The Oral Microbiome and Cancer

2020

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“…For the past decades, periodontitis has been consistently linked with several systemic diseases, such as diabetes mellitus (46), cardiovascular diseases (47, 48), adverse pregnancy outcomes (49), rheumatic diseases (50), stress (51), male and female infertility-related conditions (52,53), Alzheimer's Disease (54), inflammatory bowel disease (55), metabolic syndrome or even some types of cancers (56). In a patient-centered view, periodontitis has a negative impact on oral health-related quality of life (57), though periodontal treatment through non-surgical procedures showed to be effective to its recovery (58).…”

Section: The Ubiquitin-proteasome System In Periodontal Disease Periomentioning

confidence: 99%

The Ubiquitin Proteasome System in Periodontal Disease: A Comprehensive Review

et al. 2020

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The turnover of intracellular proteins is a highly selective and regulated process. This process is responsible for avoiding injury and irreparable breakdown of cellular constituents. Its impairment disrupts cellular stability, integrity, and homeostasis. The ubiquitin-proteasome system (UPS) is responsible for this programmed degradation of most intracellular proteins. This process involves a cascade of enzymes that involves the ubiquitin conjugation to a target substrate protein, its recognition and degradation by the proteasome. The turn-over of intracellular proteins is a non-stop ubiquitous process that regulates a series of mechanisms, for instance transcription, translation, endocytosis. In addition, proteasome act by releasing peptides that may serve to other purposes, such as antigen presentation in immune actions and enzymatic flagging toward biosynthesis and gluconeogenesis. The role of the UPS impairment in periodontal diseases is gaining growing. This acquaintance might contribute to the development of novel therapeutic applications. Thus, this review focuses on the latest progresses on the role of the UPS and its signaling pathways in Periodontal Medicine. Furthermore, we discuss the potential of UPS-based drugs development to be used in periodontal disease therapy.

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Poor oral hygiene behavior is associated with an increased risk of gastric cancer: A population‐based case‐control study in China

Zhang

Yang

Yin

et al. 2021

Journal of Periodontology

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Background: Poor oral health may be a significant risk factor for gastric cancer (GC); however, previous results are not consistent. Here, we investigated the effect of oral health on GC and effect modification by other factors. Methods: We conducted a population-based case-control study in Taixing, China. Participants aged between 40 and 85 years and who had lived in Taixing for at least 5 years were included. The GC cases were confirmed by endoscopy and pathological diagnosis, and the controls were randomly selected using the frequency-matching method. Unconditional logistic regression models were used to derive odds ratios (ORs) and 95% confidence intervals (CIs) of oral health for GC risk after adjusting for confounders and risk factors. Results: Overall, 901 GC cases and 1972 controls were included. Tooth loss was not significantly associated with an increased risk of GC (yes vs. no, OR = 1.08, 95% CI 0.88 to 1.33). Compared with toothbrushing at least twice per day, toothbrushing once per day or less was associated with an increased risk of GC (OR = 2.39, 95% CI 1.94 to 2.94), and was more pronounced in esophagogastric junction cancer and intestinal-type GC. There was no significant interaction between the indicators of oral health and age, sex, tobacco smoking, alcohol drinking, and Helicobacter pylori seropositivity. Conclusion:Poor oral hygiene behavior is associated with an increased risk of GC, and this positive association is consistent across all GC subgroups classified by anatomy and histology. Further studies are needed to explore the possible mechanisms behind this association.

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The effect of periodontal bacteria infection on incidence and prognosis of cancer

Cited by 38 publications

References 52 publications

The Oral Microbiome and Cancer

The Oral Microbiome and Cancer

The Ubiquitin Proteasome System in Periodontal Disease: A Comprehensive Review

Poor oral hygiene behavior is associated with an increased risk of gastric cancer: A population‐based case‐control study in China

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