The Effect of Percutaneous Nitroglycerin Upon the Concentration of Serotonin, Epinephrine and Norepinephrine in Venous Blood From Migrainous Subjects During Attack‐free Intervals

Dalsgaard‐Nielsen, T; Bryndum, B.; Fog‐Møeller, F.; Genefke, Inge Kemp

doi:10.1111/j.1526-4610.1975.hed1404231.x

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…According to our knowledge, only one study has previously investigated the platelet serotonin content during a nitroglycerin-induced headache attack and it failed to show any changes (Dalsgaard-Nielsen et al, 1975). In our studies, we could not detect any significant changes in platelet serotonin content in the subjects with nitroglycerininduced migraine attack.…”

Section: Discussioncontrasting

confidence: 81%

NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release

Juhász

Zsombók

Modos

et al. 2003

Pain

239

219

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The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura) and eight controls participated in the study. Sublingual nitroglycerin (0.5 mg) was administered. Blood was collected from the antecubital vein four times: 60 min before and after the nitroglycerin application, and 60 and 120 min after the beginning of the migraine attack (mean 344 and 404 min; 12 subjects). In those subjects who had no migraine attack (11 subjects) a similar time schedule was used. Plasma CGRP concentration increased significantly (P<0.01) during the migraine attack and returned to baseline after the cessation of the migraine. In addition, both change and peak, showed significant positive correlations with migraine headache intensity (P<0.001). However, plasma CGRP concentrations failed to change during immediate headache and in the subjects with no migraine attack. Basal CGRP concentration was significantly higher and platelet 5-HT content tended to be lower in subjects who experienced a migraine attack. Platelet serotonin content decreased significantly (P<0.01) after nitroglycerin in subjects with no migraine attack but no consistent change was observed in patients with migraine attack. In conclusion, the fact that plasma CGRP concentration correlates with the timing and severity of a migraine headache suggests a direct relationship between CGRP and migraine. In contrast, serotonin release from platelets does not provoke migraine, it may even counteract the headache and the concomitant CGRP release in this model.

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Section: Discussioncontrasting

confidence: 81%

NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release

Juhász

Zsombók

Modos

et al. 2003

Pain

239

219

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“…Patients with migraine have a lower threshold for reserpine induced headaches than controls. Previous investigations 9 have shown, that migraineurs have an equally low threshold for percutaneously applied nitroglycerin. But nitroglycerin had no influence on platelet serotonin concentration.…”

Section: Discussionmentioning

confidence: 88%

Concentration of Serotonin in Blood Platelets: Effect of Reserpine in Migraineurs

Genefke¹,

Dalsgaard‐Nielsen²,

Bryndum³

et al. 1975

Headache

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SYNOPSIS Twenty‐three migraineurs and 7 controls were given intramuscular injections of reserpine. Platelets 5‐HT(serotonin) was measured 4–6 hours after injection and in migraineurs at weekly intervals for six weeks. Platelet 5‐HT fell to comparable levels in migraineurs and controls but 20 migraineurs had vascular headache within six hours after reserpine injection. No control had vascular headache after reserpine administration. Decreased platelet 5‐HT levels were found for 4–6 weeks after injection of reserpine. During the period of low 5‐HT levels there was a decreased frequency and intensity of migrainous attach in patients.

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“…12 Plasma norepinephrine (NE) and epinephrine (E) were determined separately by a double isotope derivation technique. 13,14…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effect of Reserpine on Migraine Syndrome: Relationship to Blood Mine Levels

Fog‐Míller¹,

Bryndum²,

Dalsgaard‐Nielsen³

et al. 1976

Headache

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SYNOPSIS Ten migraineurs volunteered for intravenous in actions of reserpine over a period of six weeks. The clinical effects were noted and blood specimens were analyzed for norepinephrine, epinephrine and erotonin for twelve weeks. The frequency and intensity of migrainous attacks was decreased in this open trial. A marked decrease in concentration of blood amines which accompanied clinical improvement was found.

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The Effect of Percutaneous Nitroglycerin Upon the Concentration of Serotonin, Epinephrine and Norepinephrine in Venous Blood From Migrainous Subjects During Attack‐free Intervals

Cited by 4 publications

References 5 publications

NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release

NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release

Concentration of Serotonin in Blood Platelets: Effect of Reserpine in Migraineurs

Therapeutic Effect of Reserpine on Migraine Syndrome: Relationship to Blood Mine Levels

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