The effect of pentoxifylline in treatment of skin degloving injuries: An experimental study

Öztuna, Volkan; Eskandari, Metin Manouchehr; Ünal, Şakir; Çolak, Mehmet; Karabacak, Tuba

doi:10.1016/j.injury.2006.02.025

Cited by 18 publications

(18 citation statements)

References 7 publications

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“…In addition, pentoxyfilline improves red blood cells deformability, and decreases the potential for platelet aggregation. [9][10][11] Experimental studies show that pentoxifylline increases perfusion in myocutaneous and skin flaps.…”

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confidence: 99%

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Neutrophil Elastase Inhibitor Increases Flap Survival in Experimental Degloving Injuries

et al. 2018

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A vulsion and degloving injuries are caused by a vast array of mechanisms, machines and situations, in which the hand is injured with low energy shearing forces in a rigid position.[1] These types of injuries have generally been viewed as among the most problematic of injuries to manage due to their extensive nature of associated damage. During degloving injuries, blood vessels having great elasticity, are disembodied and separated with irreversible injury along the entire length of involvement and so are the tendons and nerves. Furthermore in circumferential degloving injuries, the distal flap goes through a state of abrupt ischemia followed by reverse perfusion forming after the reattachment of the flaps back to its' origin. Arnez et al, recently reclassified degloving injuries according to the Objectives: Degloving hand injuries have generally been viewed as among the most difficult of injuries to manage due to the extensive nature of associated damage. The traditional approach to the circumferentially degloved segment of problematic flap viability has been to resuture the flap and to wait and see. However, the waiting period or the specific hemorheological protocol remains uncertain. The purpose of this study is to acknowledge if Sivelestat, known to ameliorate ischemia reperfusion injury, enhances the survival of avulsed flaps in a hind limb degloving model of rats and to compare Sivelestat's effects to Pentoxifylline. Methods: Total flap area (cm 2 ), area of necrosis in the flap (cm 2 ), and the ratio between the necrotic and total areas (percentage) were determined. Angiogenesis among the groups were documented with CD31, anti-PECAM stainings. TUNEL assay was performed to allow the visualization of cell nuclei containing fragmented DNA, a typical feature of apoptosis. Results: This study demonstrated that, Sivelestat administered at 10 mg/kg/hour dosage will inhibit the ischemia reperfusion injury more pertinently than Pentoxifylline which exerts only hemorheological effects. Conclusion:The anti-inflammatory effects of Sivelestat, will be beneficial for decreasing the early complications of degloving injury, such as inflammation, sepsis, and edema, better than Pentoxifylline which exerts only hemorheological effects.

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confidence: 99%

“…[9][10][11] The purpose of this study is to acknowledge if Sivelestat, known to ameliorate IRI, enhances the survival of avulsed flaps in a hind limb degloving model of rats which was described by Milcheski et al and to compare Sivelestat's effects to a well known hemorheological agent, Pentoxifylline.…”

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confidence: 99%

Neutrophil Elastase Inhibitor Increases Flap Survival in Experimental Degloving Injuries

et al. 2018

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“…Oztuna et al proved that intraperitoneal administration of pentoxyfiline in rats improves viability of experimentally created cutaneous flaps (7). According to numerous authors, re-attachement of the avulsed flap in situ and compressive garments do not bring expected results.…”

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confidence: 99%

Severe Lower Extremities Degloving Injuries - Medical Problems and Treatment Results

Wójcicki¹,

Wojtkiewicz²,

Drozdowski³

2011

Polish Journal of Surgery

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Degloving injuries consist in detachment of skin and subcutaneous tissue from underlying fascia and muscles. They mostly address total surface of extremities or trunk, resulting in high morbidity and mortality. Their treatment, due to severity of the injury, high percentage of serious concomitant injuries and massive blood loss is time -consuming and its results are often unfavourable. The authors present results of treatment of three cases of patients with degloving injuries of the lower extremities and trunk. The patients presented poor healing prognosis connected with the extension of the injury. A complicated course of treatment was described. In all patients skin grafts healed well, resulting in acceptable aesthetic and functional outcome.

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“…Ao se realizar o reposicionamento e sutura do retalho avulsionado a sua posição original, fármacos que aumentem a viabilidade do retalho descolado poderiam ser utilizados no intuito de diminuir a área de necrose deste retalho. Há pouca referência a modelos experimentais de desenluvamentos na literatura [6][7][8] . Nenhum destes estudos se refere a lesões em membros inferiores e apenas o modelo proposto por Oztuna et al 7 O modelo utiliza ratos da linhagem Wistar, pesando entre 200 e 350 gramas.…”

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“…Há pouca referência a modelos experimentais de desenluvamentos na literatura [6][7][8] . Nenhum destes estudos se refere a lesões em membros inferiores e apenas o modelo proposto por Oztuna et al 7 O modelo utiliza ratos da linhagem Wistar, pesando entre 200 e 350 gramas. Após a anestesia (tiopental sódigo; 40 mg/ kg), realiza-se tricotomia da extremidade inferior e o animal é colocado em posição operatória.…”

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Modelo experimental para estudo de desenluvamento cutâneo no membro inferior

Milcheski

Ferreira

Tuma

et al. 2011

Rev. Bras. Cir. Plást. (Impr.)

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Milcheski DA et al. Modelo experimental para estudo de desenluvamento cutâneo no membro inferior Experimental model of degloving injury in hind limb RESUMO Os desenluvamentos cutâneos são lesões graves e frequentemente há dificuldade para o cirurgião decidir qual o tratamento mais adequado a ser instituído, o reposicionamento e a sutura do retalho ou o desengorduramento do retalho e a enxertia da pele avulsionada. A conduta cirúrgica de reposicionamento e sutura do retalho é mais rápida e simples de ser realizada, mantém as características anatômicas e fisiológicas locais, mas frequentemente evolui com perda parcial ou total do retalho avulsionado. O tratamento cirúrgico de adelgaçamento do retalho desenluvado e enxertia da pele obtida tem a desvantagem de resultar em aspecto estético e protetivo inferiores, mas é o tratamento mais utilizado, devido à maior taxa de integração do enxerto. Medicações com propriedades de aumentar a perfusão do retalho desenluvado podem permitir a conduta cirúrgica de reposicionamento e sutura do retalho ao seu leito original, mantendo as vantagens da cobertura cutânea original e preservando total ou parcialmente a viabilidade do retalho. Para tanto, há necessidade de se desenvolver um modelo experimental para testar medicações com propriedades vasculares. O presente estudo apresenta um modelo animal de desenluvamento cutâneo em membros inferiores de ratos. Os animais foram submetidos ao modelo proposto de desenluvamento de todo membro inferior, resultando em um retalho de fluxo distal, que foi reposicionado ao leito e suturado. Descritores: Ferimentos e lesões. Extremidade inferior. Pele/lesões. Necrose/etiologia. Modelos animais.

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The effect of pentoxifylline in treatment of skin degloving injuries: An experimental study

Cited by 18 publications

References 7 publications

Neutrophil Elastase Inhibitor Increases Flap Survival in Experimental Degloving Injuries

Neutrophil Elastase Inhibitor Increases Flap Survival in Experimental Degloving Injuries

Severe Lower Extremities Degloving Injuries - Medical Problems and Treatment Results

Modelo experimental para estudo de desenluvamento cutâneo no membro inferior

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