The Effect of Passage with Chloramphenicol Upon the Behavior of Penicillin-Resistant Feline Pneumonitis Virus During SubsequentPassage with Penicillin

Moulder, James W.; Ruda, Jacqueline; Colón, Julio I.; Greenland, Rima M.

doi:10.1093/infdis/102.2.186

Cited by 11 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subgroups can be separated through the study of pathogenicity patterns in experimental animals (9,12,17), in vivo toxin neutralization or prevention (4,8,16), cross-immunity tests (1,3,18), and infectivity neutralization tests in mice and eggs (6,11). The complement fixation (CF) test in general diagnostic use measures a common group antigen.…”

mentioning

confidence: 99%

Plaque Reduction Technique for Demonstrating Neutralizing Antibodies for Chlamydia

et al. 1970

View full text Add to dashboard Cite

Some members of the genus Chlamydia (Bedsonia or psittacosis-lymphogranuloma venereum-trachoma-inclusion conjunctivitis group of microorganisms) produce plaques in monolayers of mouse fibroblast (L-929) cells. Hyperimmune chicken antisera may be capable of specifically reducing plaque counts. When the test was applied to chlamydiae isolated from avian species, the results indicated that different isolates with a common source had similar antigenic reactivity. The plaque reduction test is a potentially useful method for serotyping chlamydiae. The difficult aspect of the method appears to be a readily reproducible means of producing neutralizing antiserum.

show abstract

mentioning

confidence: 99%

Plaque Reduction Technique for Demonstrating Neutralizing Antibodies for Chlamydia

et al. 1970

View full text Add to dashboard Cite

show abstract

“…Comparable results were obtained with the immunodiffusion test. A similar phenomenon has been already observed with other virus variants (ST. Jo~ and GORDON, 1947 ;MOULDER et al, 1958).…”

Section: Discussionmentioning

confidence: 99%

Clonal analysis of tumorigenesis of bovine adenovirus type 3 and isolation of a nontumorigenic variant

Nishibe

Kimura

Inoue

1970

Archiv f Virusforschung

View full text Add to dashboard Cite

SummaryThe tumorigenesis of bovine adenovirus type 3 was studied using either the wild type strain or three isolated virus clones and one experimentally induced variant, with the following results:1. The wild type strain produced non-progressive, solid or cystic tumors which induced neutralizing antibodies.2. The three cloned virus strains produced progressive, always solid tumors without the formation of neutralizing antibodies.3. The experimentally induced variant proved to be non-tumorigenic and differed in its antigenic composition.It is concluded that bovine adenovirus type 3 represents a heterogenic population of virus particles with different tumorigenic potentialities.Type 3 bovine adenovirus WBR1 strain was found to be tumorigenic for hamsters (D~YSHIRE, 1966). In this species the virus induced both solid tumors that did not appear to grow but remained static after reaching a size of 20--30 ram, and tumors of cystic type that regressed within 10 days leaving back small subcutaneous nodules. Stimulated by this observation we assumed the wild type strain of type 3 bovine adenovirus to be a mixture of genetically different virus particles.

show abstract

“…The great increase in mouse intracerebral lethality in the chlortetracycline-resistant mouse pneumonitis agent provides another example of simultaneous alteration in the specificity of the neutralizing antigen and in animal virulence during laboratory passage of members of the psittacosis group. Moulder et al (1958a) observed that a penicillin-resistant mutant of feline pneumonitis agent produced antiserum incapable of fully neutralizing the parent agent, although it was itself completely neutralized by parent antiserum. This mutant also had a lessened respiratory virulence for mice (Moulder et al, 1955).…”

Section: Discussionmentioning

confidence: 99%

“…These antigens may be conveniently demonstrated by serum neutralization tests conducted in mice (Hilleman, 1945;St. John and Gordon, 1947) or in chick embryos (Moulder et al, 1958a); the serum neutralization test is a routine method for identifying a psittacosis group agent.…”

Section: Absencementioning

confidence: 99%

See 1 more Smart Citation

Changes in Mouse Pneumonitis Agent Associated with Development of Resistance to Chlortetracycline

1965

View full text Add to dashboard Cite

MOULDER, JAMES W. (University of Chicago, Chicago, Ill.), DOROTHY L. NovoSEL, AND ILSE I. E. TRIBBY. Changes in mouse pneumonitis agent associated with development of resistance to chlortetracycline. J. Bacteriol. 89:17-22. 1965.-A chlortetracycline-resistant mutant of mouse pneumonitis agent, a member of the psittacosis group of microorganisms, differed in several ways from the susceptible stock from which it had been derived by serial chick-embryo passage in the presence of the antibiotic. It was almost completely resistant to chlortetracycline, had a longer growth cycle, produced many more very large particles, was not neutralized by parent antiserum and vice versa, was 10 times as resistant to D-cycloserine, and was highly lethal to mice when inoculated intracerebrally. These changes probably do not occur independently of one another but are the reflection of some genetically controlled change in the surface structure of the mouse pneumonitis particle which enables the resistant mutant to multiply in the presence of chlortetracycline.

show abstract

The Effect of Passage with Chloramphenicol Upon the Behavior of Penicillin-Resistant Feline Pneumonitis Virus During SubsequentPassage with Penicillin

Cited by 11 publications

References 1 publication

Plaque Reduction Technique for Demonstrating Neutralizing Antibodies for Chlamydia

Plaque Reduction Technique for Demonstrating Neutralizing Antibodies for Chlamydia

Clonal analysis of tumorigenesis of bovine adenovirus type 3 and isolation of a nontumorigenic variant

Changes in Mouse Pneumonitis Agent Associated with Development of Resistance to Chlortetracycline

Contact Info

Product

Resources

About