The effect of panretinal photocoagulation for diabetic retinopathy on retinal nerve fibre layer thickness and optic disc topography

Ritenour, Rusty; Kozousek, V; Chauhan, Balwantray C.

doi:10.1136/bjo.2007.135749

Cited by 14 publications

(19 citation statements)

References 7 publications

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“…This was followed by progressive resolution, back to baseline values at 6 months, maintained through to 12 months. This is in contrast to previous studies with conventional Argon PRP which showed a progressive thinning in RNFL in PRP treated eyes [1][2][3]5] and concurs with recent TD-OCT studies [8,13].…”

Section: Discussioncontrasting

confidence: 56%

“…This is consistent with other studies in the literature. [1,2,5,17]. This was followed by progressive resolution, back to baseline values at 6 months, maintained through to 12 months.…”

Section: Discussionmentioning

confidence: 99%

“…As the visual fields may anyway be affected by the laser PRP, this can make a diagnosis of progressive glaucoma more challenging. After primary laser injury, the laser scar lesions may coalesce, leading to functional damage such as visual field defects and if involving the macula, visual disturbance [2][3][4]. There may be discernible changes to the optic nerve head [1,[4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, it is difficult to ascertain whether an increasing CDR in post PRP treated eyes is due to glaucoma, diabetes related ischemia or simply a non-progressive injury secondary to the PRP itself. Past studies used unsophisticated or non-dedicated imaging to measure retinal nerve fiber layers (RNFL) [1,4,5,[7][8][9][10][11][12][13][14][15][16][17]. Ours is the first to use highly reproducible High Definition Spectral Domain Optical Coherence Tomography (SDOCT) of the optic nerve head (ONH) by both Cirrus (Carl Zeiss Meditec Inc, Dublin, CA) and Spectralis (Heidelberg Engineering, Heidelberg Germany).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of PASCAL Panretinal Photocoagulation on the Peripapillary Retinal Nerve Fiber Layer

Mohla¹,

Mathur²

2016

J Clin Exp Ophthalmol

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Purpose: To investigate the effects of Pascal (Topcon Medical Laser Systems, Inc. Oakland, NJ) pan-retinal photocoagulation (PRP) on the optic nerve head (ONH).Method: This was a prospective case control study comparing 3 groups of patients seen in the diabetic retinopathy (DR) clinics, without any coexistent optic nerve pathology.Group A patients had proliferative or severe non proliferative DR necessitating PRP during the study period. Group B patients had mild or moderate DR and did not require PRP throughout the study period. Group C patients had standard retinal laser (green argon or frequency doubled YAG) PRP at least 2 years ago. All the 3 Groups had retinal oxygenation measurements and retinal vessel caliber readings by Oxymap T1(Oxymap, Reykjavik, Iceland), optic disc stereophotographs, high definition optical coherence tomography (HD-OCT) scans of the ONH by both Cirrus (Carl Zeiss Meditec Inc, Dublin, CA) and Spectralis (Heidelberg Engineering, Heidelberg Germany). These were performed prior to PRP at baseline, then at 3, 6, and 12 months post PRP for group A and at baseline, 3, 6, and 12 months for groups B and C. Paired t-test was used to assess the mean changes in parameters from baseline for each group.Results: A total of 90 patients were recruited including 27 in Group A, 31 in Group B and 32 in Group C. At baseline, the average retinal nerve fibre layer (RNFL) was significantly thicker in group A compared to group B (102.0 ± 16.8 vs. 89.5 ± 11.6 μm, p=0.001) and group C (88.6 ± 11.2 μm, p=0.001) respectively. At 3 months, Group A exhibited a significant increase in the Cirrus average RNFL thickness (5.60 ± 8.54 µ, p=0.003) when compared to baseline. At 6 months, the average RNFL reverted to baseline values (p=0.89), and remained stable at 12 months (p=0.85). There was no significant change noted in the average Cirrus RNFL thickness at 3 and 6 months in Group B. At 12 months, the average RNFL was significantly thinner compared to baseline (-6.68 ± 8.10; p=0.005). In Group C, the average RNFL remained stable from baseline through to month 12 (p>0.05 at the three timepoints). No significant changes were noted in the average Spectralis RNFL thickness at any timepoints in each of the three groups.Oxygen saturation dropped in all 3 groups at 3 months, being significant only in group B (-2.05 ± 4.20%, p=0.03). Conclusion:In eyes treated with Pascal PRP, there was an initial increase in the retinal nerve fibre layer at the optic nerve head at 3 months followed by a thinning back to baseline values at 6 months which then remained stable up to 12 months. Hence the Pascal PRP did not have a significant effect on the nerve fibre layer at 12 months.Keywords: Pascal panretinal photocoagulation; Optic nerve head; Retinal nerve fibre layer thickness; Retinal oximetry; Diabetic retinopathy SummaryIn this study, we investigated the effects of Pascal (Topcon Medical Laser Systems, Inc. Oakland, NJ) pan-retinal photocoagulation (PRP) on the optic nerve head (ONH). This was a prospective case control study c...

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Section: Discussioncontrasting

confidence: 56%

“…This is consistent with other studies in the literature. [1,2,5,17]. This was followed by progressive resolution, back to baseline values at 6 months, maintained through to 12 months.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of PASCAL Panretinal Photocoagulation on the Peripapillary Retinal Nerve Fiber Layer

Mohla¹,

Mathur²

2016

J Clin Exp Ophthalmol

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“…[7][8][9][10][11] Hsu and Chung 8 demonstrated RNFL thinning of some quadrants in 27 eyes with DR after PRP. Muqit et al 10 detected an increase in average RNFL thickness at 10 weeks post-PRP and progressive thinning at 6 months post-PRP in 10 eyes.…”

mentioning

confidence: 99%

Long-Term Temporal Changes of Peripapillary Retinal Nerve Fiber Layer Thickness Before and After Panretinal Photocoagulation in Severe Diabetic Retinopathy

Kim

Woo

Ahn

et al. 2012

Retina

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Randomized Clinical Trial to Evaluate the Effects of Pascal Panretinal Photocoagulation on Macular Nerve Fiber Layer

Muqit¹,

Marcellino²,

Henson³

et al. 2011

Retina

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The effect of panretinal photocoagulation for diabetic retinopathy on retinal nerve fibre layer thickness and optic disc topography

Cited by 14 publications

References 7 publications

The Effects of PASCAL Panretinal Photocoagulation on the Peripapillary Retinal Nerve Fiber Layer

The Effects of PASCAL Panretinal Photocoagulation on the Peripapillary Retinal Nerve Fiber Layer

Long-Term Temporal Changes of Peripapillary Retinal Nerve Fiber Layer Thickness Before and After Panretinal Photocoagulation in Severe Diabetic Retinopathy

Randomized Clinical Trial to Evaluate the Effects of Pascal Panretinal Photocoagulation on Macular Nerve Fiber Layer

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