The Effect of Palm Oil-Fried Street Kokor on Liver and Kidney Biomarkers of Swiss Albino Mice

Abstract

Background. Foods fried with oils at streets contain many harmful substances for health. Locally fried foods are consumed commonly in our society, yet their health effect is not studied. Objective. To assess the effect of palm oil-fried street kokor on liver and kidney biomarkers of Swiss Albino mice. Methods. Thirty-two male and female Swiss Albino mice with the age of 10-12 weeks old were divided randomly into four groups of eight members with equal male and female subgroups. The control group (group I) received only a standard pellet, and the experimental groups (group II, group III, and group IV) received 10%, 20%, and 30% kokor of their daily food consumption, respectively. At the end of the 6th week, they were sacrificed by thoracoabdominal incision after anesthetizing by diethyl ether. Blood was taken from each mouse by cardiac puncture and analyzed for liver and kidney function tests. Result. The serum levels of liver damage biomarkers (alanine transaminase (ALT) and aspartate transaminase (AST)) and kidney damage biomarkers (urea and creatinine) of experimental groups were increased significantly relative to the control groups ( P < 0.05 ). Level of biochemical profiles increased as the dose of kokor increased. Conclusions. Palm oil-fried street kokor damaged the liver and kidney of the mice, and the damage was exacerbated as the dose of kokor increased.

Effect of Ginger Extracts on Palm Olein Quality during Frying and Impact of Fried Oils on Some Biological Parameters of Albino Wistar Rats

“…On the other hand, the low serum creatinine concentration observed in the groups of animals after consumption of palm olein enriched with plant extracts would be related to the low oxidative status of these oil samples. These results corroborate those of Amsalu et al (2020) and Chew et al (2019). Indeed, Amsalu, Wondimnew, Mateos, Fekadie & Bogale, (2020) showed that serum creatinine increased in rats following the consumption of fried palm oil, whereas the investigations of Chew et al (2019) showed that the simultaneous consumption of citrus leaf extracts and thermoxidized palm olein resulted in a decrease in serum creatinine in rats.…”

“…These results corroborate those of Amsalu et al (2020) and Chew et al (2019). Indeed, Amsalu, Wondimnew, Mateos, Fekadie & Bogale, (2020) showed that serum creatinine increased in rats following the consumption of fried palm oil, whereas the investigations of Chew et al (2019) showed that the simultaneous consumption of citrus leaf extracts and thermoxidized palm olein resulted in a decrease in serum creatinine in rats.…”

Ethanolic Extract of Syzygium cumini Causes Toxic Effects on Ethanol-induced Liver and Kidney Damage in Albino Wistar Rats: A Biochemical and Histological Study

“…The concentrations of ALT and AST in the serum are correlated with the extent of liver tissue damage [17,18]. Conversely, the reoccurrence of the aminotransferases' activities in the serum close to the normal levels indicates the hepatocytes regeneration and the recovery of the liver parenchyma [3,18,19]. Based on the results of the current study, there were indications of the liver damage in the group that received a high dose of the extract, as evident by the elevated serum AST and ALT levels.…”

“…Urea and creatinine are the most frequently ordered blood analyses to assess the status of the kidney function. Urea is produced by protein breakdown and excreted in urine whereas creatinine is a non-protein nitrogenous compound that is produced by the breakdown of creatine in muscles and excreted by filtration through the kidney at a constant rate [18]. In the current study, the serum urea levels were elevated in the rat group that received the extract at a high dose.…”

“…When the liver is damaged, especially by tox-ins, ALT and AST are released into the blood stream and their serum levels rise. The concentrations of ALT and AST in the serum are correlated with the extent of liver tissue damage [17,18]. Conversely, the reoccurrence of the aminotransferases' activities in the serum close to the normal levels indicates the hepatocytes regeneration and the recovery of the liver parenchyma [3,18,19].…”