For detecting weld seams deviation during the industrial actual welding process, IPG YLR-10000 high power fiber laser welding equipment was used during laser welding experiments. A high-speed near-infrared camera was used to capture the dynamic welding pool image sequences. Through studying the change of the features of near-infrared images of the weld pool when the laser beam deviated the weld seam, the centroid of the welding pool could be used as the deviated parameter of the weld seam. The welding pool images coordinates were established, and the ways of rotating and shifting the coordinates were used to build a model to test the welding spots deviation. Finally, the model of the relationship of the actual weld seam deviation and the tested weld seam deviation had been set up by using the regression analysis method. Its validity and feasibility had been tested by analyzing the models correlation R parameters.