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Introduction: Saliva plays a key role in the oral cavity health. It contains many defense elements and is considered a cornerstone in the oral metabolism. Objective:The aim of this study was to investigate the changes in the salivary concentrations of calcium, glucose, total protein, lactate dehydrogenase and alkaline phosphatase in patients undergoing removable orthodontic appliances treatment.Methods: Ninety saliva samples were collected from thirty subjects ranging in age from 8 to 11 years. An initial sample was attained before starting treatment with removable orthodontic appliances; a second sample 1 month after treatment and a third sample was obtained three months following treatment. The saliva was collected from each patient in pre-labeled sterile containers using the passive drool method.Results: Salivary lactate dehydrogenase and alkaline phosphatase concentrations were significantly increased in patients undergoing removable orthodontic treatment after as compared to before treatment. There was also an increase in the calcium, glucose and total protein concentrations but the differences were insignificant. Conclusion:Removable orthodontic treatment changes the oral fluid contents, promotes an increase in the levels of salivary lactate dehydrogenase and alkaline phosphatase enzymes after one month of treatment with increased values after three months. These oral changes emphasize the importance of maintaining proper oral hygiene measures during treatment.
Introduction: Saliva plays a key role in the oral cavity health. It contains many defense elements and is considered a cornerstone in the oral metabolism. Objective:The aim of this study was to investigate the changes in the salivary concentrations of calcium, glucose, total protein, lactate dehydrogenase and alkaline phosphatase in patients undergoing removable orthodontic appliances treatment.Methods: Ninety saliva samples were collected from thirty subjects ranging in age from 8 to 11 years. An initial sample was attained before starting treatment with removable orthodontic appliances; a second sample 1 month after treatment and a third sample was obtained three months following treatment. The saliva was collected from each patient in pre-labeled sterile containers using the passive drool method.Results: Salivary lactate dehydrogenase and alkaline phosphatase concentrations were significantly increased in patients undergoing removable orthodontic treatment after as compared to before treatment. There was also an increase in the calcium, glucose and total protein concentrations but the differences were insignificant. Conclusion:Removable orthodontic treatment changes the oral fluid contents, promotes an increase in the levels of salivary lactate dehydrogenase and alkaline phosphatase enzymes after one month of treatment with increased values after three months. These oral changes emphasize the importance of maintaining proper oral hygiene measures during treatment.
Abstract-The identification of the onset of pubertal growth phase in growing patients is very important for orthodontists to determine orthodontic treatment planning and timing. The timing of growth phase can be assessed using chronological age, skeletal age, physiological age, dental age and biomarkers. ALP is one of the biomarkers that can be easily obtained from saliva. The increase of ALP levels in growing subjects is one of the indications of bone mineralization. The objective of this study was to assess the level of ALP in growing subjects in relation to the pubertal growth phase and age. This research was an observational analytic research with cross sectional design. Samples in this study consisted of 57 healthy growing female subjects (age ranging from 8 to 15 years). Growth phase was assessed through the cervical vertebral maturation (CVM) method described by Hassel and Farman. The subjects were divided into three groups according to their growth phases, which were prepubertal (CVM 1 and CVM 2), pubertal (CVM 3 and CVM 4), and post pubertal (CVM 5 and CVM 6). Unstimulated whole saliva collected from each subject and the level of ALP were measured using spectrophotometer. Results showed that peak levels of ALP were observed in pubertal growth phase: 233.39 ± 106.29 (IU/L), followed by prepubertal growth phase: 192.87 ± 69.02 (IU/L), and post pubertal growth phase: 79.20 ± 31.41(IU/L). The highest ALP levels were found at 10-11 years, and at 8-9 years, 12-13 years, and 14-15 years respectively. As conclusion, the level of ALP in saliva can be used as biomarker for the pubertal growth phase identification to determine orthodontic treatment planning and timing.
Aim:The current study was aimed to determine the relationship between the orthodontic force applied by monobloc and the salivary level of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) enzymes, considering the time factor after insertion of the appliance and whether there is a correlation between these enzymes. Materials and methods:A sample of 28 growing patients requiring orthodontic treatment with myofunctional appliance (Monoblock) was taken for the current study with an age range 9 to 12 years,all patients had Angle's class II division 1 malocclusion with no or mild crowding, the sample was selected using simple random sampling. Only 16 subjects (10 males and 6 females) were included who follow certain inclusion criteria. Unstimulated saliva was collected from the patients before monoblock insertion, then 1 hour after insertion, followed by 14 days and 28 days. Salivary levels of ALP and LDH were measured using a spectrophotometer and compared with the base line. Results:The results revealed that ALP and LDH levels increased with increasing time after monoblock insertion, and there was the statistically insignificant difference after 1-hour post-insertion for ALP enzyme level, but highly significant after 14 and 28 days. While for LDH level,there was the statistically significant difference after 1-hour post-insertion, but highly significant difference after 14 and 28 days post-insertion. In this regard to the relation between salivary ALP and LDH enzymes levels at different time intervals, showed that there were no significant correlations between the enzymes using Pearson's correlation test. Conclusion:The ALP and LDH salivary enzymes activity is affected by mechanical forces generated by monobloc activator and these enzymes activities can also be increased during the rapid growth phase of childhood such as late infancy and early puberty where the age of subjects was selected in the current study. Clinical significance:The determination of ALP and LDH salivary enzymes activities during the skeletal maturity is crucial for the success of myofunctional monobloc treatment; therefore, saliva can be used as a noninvasive diagnostic tool for determination of chemical biomarkers for detection of bone remodeling process during myofunctional monoblock treatment
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