The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice

Chemopreventive Efficacy of Moringa oleifera Pods Against 7, 12-Dimethylbenz[a]anthracene Induced Hepatic Carcinogenesis in Mice

“…Inhibitory role of DMBA in protein synthesis may be due to reduced DNA and RNA content. Moreover the carcinogen perturbs intracellular Ca 2+ homeostasis and damages the endoplasmic reticulum, which in turn results in protein depletion (Sharma et al, 2010). In the present study DMBA intake increased the mean values of cholesterol in tissues.…”

“…The pathophysiological consequences owing to depletion of GSH have been well studied. Glutathione is highly abundant in cytosol, nuclei and mitochondria, and is the major soluble antioxidant in these cell compartments (Sharma et al, 2010). The depletion of GSH promotes generation of reactive oxygen species and oxidative stress with cascade of effects thereby affecting functional as well as structural integrity of cell and organelle membranes (De Leve et al, 1996;Singh et al, 2000).…”

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

“…It may have important role as a chemopreventive agent against cancers of prostate, stomach, breast and lung . A positive correlation has been confirmed between dietary supplementation with some antioxidants and the reduction of toxic effects of various toxicants, environmental agents (Sharma et al 2010). In the light of aforesaid medical properties of lycopene, this study was carried out to determine the possible protective effects of lycopene on oxidative stress and toxicity related biochemical and histologic parameters in kidney and serum of furan intoxicated diabetic rats.…”

Does allicin combined with vitamin B-complex have superior potentials than alpha-tocopherol alone in ameliorating lead acetate-induced Purkinje cell alterations in rats? An immunohistochemical and ultrastructural study

“…Vitamin B-complex and a-tocopherol acetate were also obtained from Sigma-Aldrich Chemicals Co. A 5000 mg/L solution of novel stabilised AEAllicin was purchased from Allicin International Limited, United Kingdom. The purity and concentration of the latter solution was determined by high-performance liquid chromatography [15,41].…”