The Effect of Omeprazole Drug on the Blood Picture of Laboratory Rat Rattus Norvegicus

Jassim, Suhad Y.; Hussin, Amer M.

doi:10.9790/3008-1203045659

Cited by 1 publication

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“…While we do not and cannot categorically connect long-term use of OME with liver damage based on findings in this study, we believe that this is an area that requires further research. It is important to note that OME has been reported to lead to liver damage (Fatima et al, 2019), show a negative effect on hepatic regeneration (Kucuk et al, 2006) and produce elevated levels of GPT and GOT liver enzymes which are indicative of liver dysfunction (Jassim and Nasser, 2018). Additionally, omeprazole was reported to induce increases in AST, ALT, and cholesterol which decreased after cessation of treatment (Elmahdy and Almater, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Akindele,

Oyerinde,

Olatoye

et al. 2023

Annals of Science and Technology

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Despite the widespread use of omeprazole (OME), there are still concerns about its long-term safety and tolerability, especially with long-term or indiscriminate use. This study was designed to evaluate the effect of 90 days sub-chronic administration of OME on haematological, biochemical, antioxidant, reproductive and histopathological parameters in male and female rats. Forty-eight (48) Wistar rats of both sexes were divided into 4 groups of 6 male and 6 female animals each. Group I received 10 mL/kg normal saline, while Groups II – IV received 0.12 mg/kg, 0.57 mg/kg, 2.85 mg/kg of OME respectively for 90 days. At the end of 90 days, 5 mL blood sample was collected, and vital organs were harvested for relevant analyses. In this study, OME did not elicit any significant (P>0.05) change in the body weight or weight of vital organs, but elicited a significant (P<0.05) reduction in sperm count at the supratherapeutic dose (2.85 mg/kg). The supratherapeutic dose of OME produced significant increase in cholesterol (P<0.0001) and LDL (P<0.0001) in female rats. OME did not generally produce a significant change in haematological parameters. OME elicited a significant decrease in CAT (P<0.05) in female and combined animals. Additionally, histopathological presentations of vital organs were generally non-abnormal. From this study, it can be concluded that long term administration of OME is generally safe and tolerable, especially at lower doses. Findings from this study suggest that OME may potentially induce changes in sperm characteristics (in relation to male rats), hepatoxicity, hypercholesteremia, hyperlipidemia and thrombocytosis over a long duration, at higher doses and especially in female animals.

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Section: Discussionmentioning

confidence: 99%

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Akindele,

Oyerinde,

Olatoye

et al. 2023

Annals of Science and Technology

View full text Add to dashboard Cite

show abstract

The Effect of Omeprazole Drug on the Blood Picture of Laboratory Rat Rattus Norvegicus

Abstract: : In the current study the long-term effect of omeprazole was determined by measuring some hematological parameters .Three groups of laboratory rats were taken each group (6)

Cited by 1 publication

References 12 publications

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

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