The Effect of Nutrient Supplementation in Management of Polycystic Ovary Syndrome Associated Metabolic Dysfunctions: A Critical Review

Günalan, Elif; Yaba, Aylin; Yılmaz, Bayram

doi:10.4274/jtgga.2018.0077

Cited by 49 publications

(54 citation statements)

References 145 publications

(144 reference statements)

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“…Other antioxidants, such as epigallocatechin 3-gallate, vitamin E, and resveratrol, have been suggested to have similar effects (170). Vitamin D replacement may have some beneficial effects on IR (185).…”

Section: Expert Opinionmentioning

confidence: 99%

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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Polycystic ovary syndrome (PCOS) is a very common endocrine and metabolic disorder with the involvement of both genetic and environmental factors. Although much has been clarified on its pathogenesis, diagnosis, clinical manifestations, and therapy, there are still areas of uncertainty. To address fundamental concepts, novel aspects and hypotheses, and future perspectives, including the possible additional benefits of treatment with nutraceuticals, an expert consensus panel formed by endocrinologists and gynecologists was established. After an independent review of the literature, the panel convened electronically on February 3, 2020, and six resolutions were created, debated, and agreed upon discussion, and finally approved in their final form in a consensus livestream meeting held on April 15. The summary of the resolutions are: (1) PCOS is a well-established medical condition that negatively affects reproduction, general health, sexual health, and quality of life; (2) the symptoms and signs of PCOS appear early in life especially in female newborns from PCOS carriers; (3) women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes mellitus; (4) a male PCOS equivalent exists, and it may impact on metabolic health and probably on reproduction; (5) the evidence supports that medical therapy for PCOS is effective, rational, and evidence-based; (6) the evidence supports a major research initiative to explore possible benefits of nutraceutical therapy for PCOS. The proposed resolutions may be regarded as points of agreement based on the current scientific evidence available.

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Section: Expert Opinionmentioning

confidence: 99%

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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“…This is partially explained by the fact that both kinds of PUFAs compete for the same enzymes and excess ω-6 PUFAs may shift the metabolism towards a pro-inflammatory state. Consequently, for chronic inflammatory states including cardiovascular disease [ 84 ], metabolic syndrome [ 83 ], diabetes mellitus [ 49 ], or the prevention and treatment of atherosclerosis [ 85 ], beneficial effects of ω3-PUFAs have been demonstrated. The protective effect originates from a reduction in pro-inflammatory eicosanoids and concomitant increase in pro-resolving mediators.…”

Section: Spms: Potential New Treatment Options For Pcosmentioning

confidence: 99%

Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response

Regidor¹,

Mueller²,

Sailer³

et al. 2020

IJMS

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PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15% of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics.

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“…Сучасні погляди лікування ПКЯ передбачають дотримання здорового способу життя та харчування, нормалізацію сну, маси тіла і в разі необхідності -проведення медикаментозної терапії. У сучасній науковій літературі обґрунтована доцільність використання в лікуванні ПКЯ вітамінно-мінеральних комплексів [3]. Роль макро-та мікроелементів у виникненні цього захворювання практично невідома.…”

Section: вступunclassified

The role of macro- and microelements in the pathogenesis of polycystic ovary

Prodanchuk¹,

Татарчук²,

Gunkov³

et al. 2019

Reproductive Endocrinology

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The Effect of Nutrient Supplementation in Management of Polycystic Ovary Syndrome Associated Metabolic Dysfunctions: A Critical Review

Cited by 49 publications

References 145 publications

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response

The role of macro- and microelements in the pathogenesis of polycystic ovary

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