The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study

Burns can have different etiologies and different areas and degrees. Depending on the severity, they can be accompanied by significant morbidity and mortality. Prompt diagnosis and appropriate treatment decrease the duration of healing and chronic complications. Alongside skin grafts, there are a multitude of modern treatment techniques, such as negative pressure therapy or skin substitutes, that decrease the inflammatory response and the infectious risk, and promote healing. The use of these methods depends on the doctors’ experience, product availability and cost-benefit ratio.

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Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound

Мартусевич

Struchkov²,

Назаров

et al. 2022

Applied Sciences

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The aim of this work was the comparative estimation of the efficiency of different variants of local ozone therapy in experimental burn wound. We conducted the experiments on 45 white Wistar rats being randomized for three groups. Every rat got contact thermal trauma (III degree; 20 bsp) of dorsal body surface on the area 20%. Rats of the first group received a Levomecol treatment of wound, animals of the second group were locally treated by ozonized oil, and the third group rats received a combination of ozone and oxygen gas mixture intracutaneously, and the wounds were treated with Levomecol locally. The character and particularities of post-traumatic regeneration were studied by histological investigation. Local treatment with reactive oxygen species at an early period after burning is revealed to lead to more pronounced manifestation of reparative processes in burn wounds (production of granulation tissue, epidermis regeneration) than when applying Levomecolointment, and that is accompanied by more pronounced initial manifestation of scab rejection. Applying reactive oxygen species in ointment compositions at these stages of treatment with the conjuncture of infected wounds does not contribute marked initiation of reparative processes and can even force the inflammation processes.

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The effect of NPWT in wound healing and bacterial count on deep dermal burn injury model: An experimental study

Cited by 4 publications

References 16 publications

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Estimation of Effectiveness of Local Reactive Oxygen Species for Stimulation of Regenerative Processes in Experimental Burn Wound

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