The Effect of Noradrenaline and Adrenaline on Hepatosplanchnic Hemodynamics, Functional Capacity of the Liver and Hepatic Metabolism

Abstract

KRARUP, N. T h e effect of noradrenaline and adrenaline on hepatosplanchnic hemo-dynamics, functional capacity of the liver and hepatic metabolism. Acta physiol. scand. 1973. 87. 307-319. Cats in the postabsorptive state and anesthetized with chloralose were used for the experiments.Following a control period noradrenaline and adrenaline at doses of 0.5, 1.0, 2.0, and 5.0,ug/kg/min were infused continiiously for about an hour into a femoral vein. Noradrenaline caused a pronounced constriction of the hepatic artery and a slight increase in the mesenteric vascular resistance. Small doses of adrenaline had a slight dilatory effect on the hepatic artery and mesenteric vessels whereas the largest dose caused a slight constriction in both these vascular beds. Neither of the drugs changed the portal venous resistance. The catecholamine infusions resulted in hepatic glycogenolysis and glycolysis, but neither the splanchnic elimination of ethanol, the secretion and composition of bile, excretion of Indocyanine Green nor the splanchnic oxygen consumption were affected, indicating that the number of sinusoids perfused was not changed. A slight effect on the hepatic clearance and extraction ratio of

Effects of exercise and restrained eating behaviour on appetite control

“…However, noradrenaline may be involved, as it plays a key role in energy metabolism, i.e. by increasing glycolysis (134) with consequent release of glucose into the bloodstream. Plasma noradrenaline levels have been reported to be lower in restrained normal-weight women after a meal (113) , therefore offering a plausible explanation for the lower postprandial glucose plasma levels observed in restrained eaters in the present study.…”

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

“…It must be emphasized that a review of all available data currently does not allow a conclusion. Although some groups have described a dose‐dependent increase of HAF and PVF after Epi administration,15 others have found a decreased HAF and PVF at low dosages 48. In the native liver group, we could show that PVF and THF values were significantly correlated during Epi and NorEpi infusion whereas HAF and PVF did not show a significant correlation.…”

“…When NorEpi is infused into the portal vein, both unchanged and decreased PVFs have been reported. Epi and NorEpi can potentially increase portal vein resistance via constriction of portal and central venules43–45 resulting in a reduction of splanchnic blood flow, which in turn decreases PVF 21, 42, 46–48. It must be emphasized that a review of all available data currently does not allow a conclusion.…”

Secretin‐like choleretic effect of prostaglandins E1 and E2 in cats.

“…Mean arterial and portal venous blood pressure were recorded by means of condensator manometers (Elema Sch6nander). These methods have been previously described in detail (Krarup, 1973 …”

“…All specimens were corrected for quenching by means of an external standard. The determinations of ethanol, ICG, oxygen, and glucose have been previously described (Krarup & Larsen, 1972;Krarup, 1973).…”