The effect of nonspecific immunostimulation of pregnant mares with 1,3/1,6 glucan and levamisole on the immunoglobulins levels in colostrum, selected indices of nonspecific cellular and humoral immunity in foals in neonatal and postnatal period

Krakowski, Leszek; Krzyzanowski, J; Wrona, Z.; Siwicki, Andrzej K.

doi:10.1016/s0165-2427(99)00006-9

Cited by 49 publications

(33 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…polymyxa JB115 was isolated from Korean soil as a glucan producer (Table 1) for the development of animal feed additives. It has a β-(1 3)-and β-(1 6)-linked glucan parastructure which are known as biological response modifi ers (BRMs) and natural immunomodulators [76] and the β-(1 3) backbone is essential for antitumor activity [77]. High molecular weight glucan (above 100 kDa) can be used as an animal feed additive for immune-enhancement and as a potential antitumor agent for livestock [78].…”

Section: P Polymyxa As Biotechnological Agent In Industrial Processesmentioning

confidence: 99%

Ecology and biotechnological potential of Paenibacillus polymyxa: a minireview

2009

View full text Add to dashboard Cite

Microbial diversity is a major resource for biotechnological products and processes. Bacteria are the most dominant group of this diversity which produce a wide range of products of industrial signifi cance. Paenibacillus polymyxa (formerly Bacillus polymyxa), a non pathogenic and endospore-forming Bacillus, is one of the most industrially signifi cant facultative anaerobic bacterium. It occurs naturally in soil, rhizosphere and roots of crop plants and in marine sediments. During the last two decades, there has been a growing interest for their ecological and biotechnological importance, despite their limited genomic information. P. polymyxa has a wide range of properties, including nitrogen fi xation, plant growth promotion, soil phosphorus solubilisation and production of exopolysaccharides, hydrolytic enzymes, antibiotics, cytokinin. It also helps in biofl occulation and in the enhancement of soil porosity. In addition, it is known to produce optically active 2,3-butanediol (BDL), a potentially valuable chemical compound from a variety of carbohydrates. The present review article aims to provide an overview of the various roles that these microorganisms play in the environment and their biotechnological potential.

show abstract

Section: P Polymyxa As Biotechnological Agent In Industrial Processesmentioning

confidence: 99%

Ecology and biotechnological potential of Paenibacillus polymyxa: a minireview

2009

View full text Add to dashboard Cite

show abstract

“…This product has been proven to be beneficial in various animal species, such as fish (1,15), shellfish (34), mice (11,14,41), pigs (33), and horses (19), because it induces greater resistance to infections, better growth, and/or a favorable feed conversion. Whereas a lot is already known about the effects of ␤-1,3/1,6-glucans on the innate immune system (5,16), a great deal still needs to be learned about their effects on the adaptive immune system in mammals.…”

mentioning

confidence: 99%

Oral Administration of β-1,3/1,6-Glucan to Dogs Temporally Changes Total and Antigen-Specific IgA and IgM

Stuyven

Verdonck

Hoek

et al. 2010

Clin Vaccine Immunol

View full text Add to dashboard Cite

The effect of oral administration of ␤-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this ␤-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.

show abstract

“…In the case of horses, the administration of 1,3--glucan to pregnant mares has been able to increase the cellular immune response in foals. This becomes very useful for preventing premature deaths of neonates [75]. While most studies have focused on the effects of 1,3--glucans on improving innate immunity, when these polysaccharides are administered to dogs, they showed enhancement in humoral immunity as indicated by changes in serum IgM and IgA levels [18].…”

Section: Infection Preventionmentioning

confidence: 99%