The Effect of Nicorandil on Ischemia-Reperfusion Injury in a Porcine Total Hepatic Vascular Exclusion Model

Yamazaki, Hodaka; Oshima, Kiyohiro; Sato, Hiroaki; Kobayashi, Katumi; Suto, Yujin; Hirai, Keitaro; Odawara, Hiroki; Matsumoto, Koshi; Takeyoshi, Izumi

doi:10.1016/j.jss.2009.09.049

Cited by 12 publications

(5 citation statements)

References 31 publications

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“…Additionally, APAP caused centrilobular hepatic necrosis as seen in histopathological examination which is in line with previous study (Hinson et al 2010). Nicorandil ameliorated the biochemical parameters in accordance with previous studies (Elshazly 2015;Yamazaki et al 2011). Moreover, nicorandil managed to alleviate APAP-induced necrosis seen in histopathological examination.…”

Section: Discussionsupporting

confidence: 91%

Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis

El‐Kashef

Sharawy

2022

Environ Sci Pollut Res

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Acetaminophen (APAP) overdose can produce hepatotoxicity and consequently liver damage. This study investigated the hepatoprotective impacts of nicorandil on hepatic damage induced by APAP. Nicorandil was administered orally (100 mg/kg) for seven days before APAP challenge (500 mg/kg, ip). Pretreatment with nicorandil reduced serum levels of aminotransferases, bilirubin, GGT and LDH, and increased serum level of albumin. Moreover, nicorandil inhibited the increase in liver MDA levels and reversed the decline in GSH content and SOD activity. Besides, it notably alleviated APAP-induced necrosis observed in histopathological findings. Additionally, nicorandil alleviated APAP-induced NO overproduction and iNOS expression; however, the protein expression of eNOS was significantly increased. Moreover, nicorandil markedly reduced hepatic TNF-α and NF-κB levels, in addition to decreasing the protein expression of MPO in hepatic tissues. Furthermore, flow cytometry (annexin V-FITC/PI) displayed a significant decline in late apoptotic and necrotic cells, and an increase in viable cells in nicorandil group. Also, nicorandil caused a significant boost in hepatic antiapoptotic marker bcl-2 level. The presented data proposed that the protective effect of nicorandil might be attributed to its antioxidant, its impact on NO homeostasis, and its anti-inflammatory properties. Therefore, nicorandil may be a promising candidate for protection from liver injury induced by APAP. Graphical abstract

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Section: Discussionsupporting

confidence: 91%

Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis

El‐Kashef

Sharawy

2022

Environ Sci Pollut Res

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“…It is supposed that the aspect as a nitrate did not express remarkably in both the nicorandil and the glibenclamide groups in this study. The organ-specificity also might influence the difference in timing when effects of nicorandil appeared between the previous (the effects of nicorandil on hepatic IR injury appeared earlier) [19] and the present studies.…”

Section: Discussionmentioning

confidence: 54%

“…We have already demonstrated that nicorandil could reduce IR injury in a porcine total hepatic vascular exclusion model, and the K ATP channel-opener aspect of nicorandil might be primarily responsible for its role in reducing IR injury [19]. In the present study, we investigated the role of K ATP channels on small intestinal warm IR injury with parameters described above in a canine model.…”

Section: Discussionmentioning

confidence: 80%

The Effect of Nicorandil on Small Intestinal Ischemia–Reperfusion Injury in a Canine Model

et al. 2011

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“… 26 Additionally, a study conducted on pigs revealed that NICD augmented hepatic blood flow and mitigated liver ischemia-reperfusion injury. 27 Another animal study has demonstrated that continuous NICD infusion could prevent the progression of liver fibrosis. 28 Consequently, it is presumed that NICD’s ability to relax hepatic blood vessels may augment hepatic blood flow, enhance hepatic metabolic capacity, leading to confer a degree of hepatoprotection.…”

Section: Discussionmentioning

confidence: 99%

Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study

Chen,

Liu,

et al. 2024

DDDT

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Background The potential myocardial protective effect of nicorandil (NICD) in patients undergoing percutaneous coronary intervention has been established. However, its efficacy in the context of cardiac surgery remains controversial. The present study aimed to evaluate the myocardial protective effect of perioperative NICD use in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Methods We retrospectively gathered data from patients undergoing cardiac bypass surgery between 12/2018 and 04/2021 in Fuwai Hospital. Subsequently, the patients were divided into two groups, NICD group and non-nicorandil (non-NICD) group. A 1, 3 propensity score matching (PSM) was conducted. The primary outcome was the incidence of myocardial injury. The secondary outcomes included the mechanical ventilation (MV) duration, intensive care unit (ICU) length of stay (LOS), hospital LOS, duration of chest drainage, the drainage volume, the total cost, the incidence of acute kidney injury (AKI), and the incidence of acute liver injury (ALI). Subsequently, we divided the entire population into two distinct subgroups based on their administration of NICD, and performed a comprehensive subgroup analysis. Results A total of 2406 patients were ultimately included in the study. After PSM, 250 patients in NICD group and 750 patients in non-NICD group were included in the analysis. Perioperative NICD reduced the incidence of myocardial injury (47.2% versus 38.8%, P=0.025). Our subgroup analysis revealed that preoperative NICD administration not only provided myocardial protection benefits (45.7% vs 35.8%, OR 0.66, 95% CI [0.45–0.97], P=0.041), but also demonstrated statistically significant reduction in ALI, the ICU and hospital LOS, and the duration of chest drainage (all P<0.05). Conclusion The perioperative NICD administration may confer myocardial protection in patients undergoing cardiac surgery with CPB. Furthermore, the preoperative utilization of NICD has the potential to mitigate the incidence of postoperative ALI, a reduction in the ICU and hospital LOS, and the duration of chest drainage.

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The Effect of Nicorandil on Ischemia-Reperfusion Injury in a Porcine Total Hepatic Vascular Exclusion Model

Cited by 12 publications

References 31 publications

Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis

Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis

The Effect of Nicorandil on Small Intestinal Ischemia–Reperfusion Injury in a Canine Model

Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study

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