The Effect of Nicorandil on Small Intestinal Ischemia–Reperfusion Injury in a Canine Model

Suto, Yujin; Oshima, Kiyohiro; Arakawa, Kazuhisa; Sato, Hiroaki; Yamazaki, Hodaka; Matsumoto, Koshi; Takeyoshi, Izumi

doi:10.1007/s10620-011-1623-0

Cited by 6 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, other studies have demonstrated exacerbated mucosal injury during reperfusion. In these studies [ 8 , 29 ], rats or cats were used for IR injury. The levels of xanthine oxidase-xanthine dehydrogenase were much higher in these species compared to pig [ 19 , 28 ], which may account for the discrepant results in our study.…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Perfusion Imaging Detection of Microcirculatory Dysfunction in Small Intestinal Ischemia-Reperfusion Injury in a Porcine Model

Shi

Qiang

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

ObjectiveTo evaluate multi-slice computed tomography (CT) perfusion imaging (CTPI) for identifying microcirculatory dysfunction in small intestinal ischemia−reperfusion (IR) injury in a porcine model.Materials and MethodsFifty-two pigs were randomly divided into 4 groups: (1) the IR group (n = 24), where intestinal ischemia was induced by separating and clamping the superior mesenteric artery (SMA) for 2 h, followed by reperfusion for 1, 2, 3, and 4 h (IR-1h, IR-2h, IR-3h, and IR-4h; n = 6, respectively); (2) the sham-operated (SO) group (n = 20), where the SMA was separated without clamping and controlled at postoperative 3, 4, 5, and 6 h (SO-3h, SO-4h, SO-5h, and SO-6h; n = 5, respectively); (3) the ischemia group (n = 4), where the SMA was separated and clamped for 2 h, without reperfusion, and (4) baseline group (n = 4), an additional group that was not manipulated. Small intestinal CTPI was performed at corresponding time points and perfusion parameters were obtained. The distal ileum was resected to measure the concentrations of malondialdehyde (MDA) and superoxide dismutase (SOD) and for histopathological examination.ResultsThe perfusion parameters of the IR groups showed significant differences compared with the corresponding SO groups and the baseline group (before ischemia). The blood flow (BF), blood volume (BV), and permeability surface (PS) among the 4 IR groups were significantly different. BF and BV were significantly negatively correlated with MDA, and significantly positively correlated with SOD in the IR groups. Histopathologically, the effects of the 2-h ischemic loops were not significantly exacerbated by reperfusion.ConclusionCTPI can be a valuable tool for detecting microcirculatory dysfunction and for dynamic monitoring of small intestinal IR injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Computed Tomography Perfusion Imaging Detection of Microcirculatory Dysfunction in Small Intestinal Ischemia-Reperfusion Injury in a Porcine Model

Shi

Qiang

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…La inmensa mayoría de las investigaciones realizadas hasta el momento, han sido llevadas a cabo empleando a la rata como animal de experimentación (77)(78)(79)(80) . No obstante, alguna publicación ha empleado al perro (68)(69)(70)(164)(165)(166)(167) , ratón (160) y el conejo (72-74, 106, 168) para el estudio de la isquemia-reperfusión intestinal.…”

Section: Altura De Las Vellosidadesunclassified

“…Su división en 5 grados resulta más sencilla y de una mayor correlación histopatológica estricta que los 8 de la clasificación de Park et al de 1990 (95) , la cual fue establecida tras estudios de isquemia intestinal con estrangulación venosa, o la de Zingarelli de 2001 (171) , con una limitada aceptación. La mayoría de los estudios publicados al respecto, realizan sus exámenes histológicos según la clasificación de Chiu (167,172,173,174) .…”

Section: 3 Justificación De Las Técnicas De Microscopíaunclassified

Estudio de los efectos del Amlodipino y Cilostazol sobre el intestino en un modelo experimental de Isquemia-Reperfusión intestinal

Barrio¹,

Henar²

View full text Add to dashboard Cite

show abstract

Pré‐tratamento com remifentanil protege contra a redução da contratilidade intestinal relacionada à lesão de isquemia e reperfusão em ratos

Özaçmak

TURAN

et al. 2015

Brazilian Journal of Anesthesiology

View full text Add to dashboard Cite

show abstract

The Effect of Nicorandil on Small Intestinal Ischemia–Reperfusion Injury in a Canine Model

Abstract: This study suggests that nicorandil has a protective effect on small intestinal IR injury, and activation of KATP channels plays an important role in inhibiting small intestinal IR injury.

Cited by 6 publications

References 33 publications

Computed Tomography Perfusion Imaging Detection of Microcirculatory Dysfunction in Small Intestinal Ischemia-Reperfusion Injury in a Porcine Model

Computed Tomography Perfusion Imaging Detection of Microcirculatory Dysfunction in Small Intestinal Ischemia-Reperfusion Injury in a Porcine Model

Estudio de los efectos del Amlodipino y Cilostazol sobre el intestino en un modelo experimental de Isquemia-Reperfusión intestinal

Pré‐tratamento com remifentanil protege contra a redução da contratilidade intestinal relacionada à lesão de isquemia e reperfusão em ratos

Contact Info

Product

Resources

About