The Effect of Neurodegeneration on Visuomotor Behavior in Alzheimer’s Disease and Parkinson’s Disease

Boer, Casper de; Steen, J. van der; Mattace-Raso, Francesco; Pel, J.J.M.

doi:10.1123/mc.2014-0015

Cited by 20 publications

(22 citation statements)

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“…Put into the theoretical framework, these prolonged fixations to the hand and object during interaction arise because without sensory feedback, a lack of confidence in the object manipulation essentially freezes the landscape, leaving the object as the most relevant location and preventing the eyes from moving ahead to the drop-off site. As well, it has recently been shown that individuals experiencing neurodegenerative brain disorders like Alzheimer's disease and Parkinson's disease exhibit characteristic visuomotor profiles that could be used in a clinical setting (de Boer, van der Steen, Mattace-Raso, Boon, & Pel, 2016). An extension of our study to clinical populations like those who use upper-limb prostheses and those with movement disorders such as Alzheimer's disease and Parkinson's disease could provide interesting information and insight into altered visuomotor behavior in impaired states.…”

Section: Discussionmentioning

confidence: 99%

Using synchronized eye and motion tracking to determine high-precision eye-movement patterns during object-interaction tasks

et al. 2018

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This study explores the role that vision plays in sequential object interactions. We used a head-mounted eye tracker and upper-limb motion capture to quantify visual behavior while participants performed two standardized functional tasks. By simultaneously recording eye and motion tracking, we precisely segmented participants' visual data using the movement data, yielding a consistent and highly functionally resolved data set of real-world object-interaction tasks. Our results show that participants spend nearly the full duration of a trial fixating on objects relevant to the task, little time fixating on their own hand when reaching toward an object, and slightly more time-although still very little-fixating on the object in their hand when transporting it. A consistent spatial and temporal pattern of fixations was found across participants. In brief, participants fixate an object to be picked up at least half a second before their hand arrives at the object and stay fixated on the object until they begin to transport it, at which point they shift their fixation directly to the drop-off location of the object, where they stay fixated until the object is successfully released. This pattern provides additional evidence of a common system for the integration of vision and object interaction in humans, and is consistent with theoretical frameworks hypothesizing the distribution of attention to future action targets as part of eye and hand-movement preparation. Our results thus aid the understanding of visual attention allocation during planning of object interactions both inside and outside the field of view.

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Section: Discussionmentioning

confidence: 99%

Using synchronized eye and motion tracking to determine high-precision eye-movement patterns during object-interaction tasks

et al. 2018

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“… 41 For the PES, it was analysed and provided for the subgroup of family caregivers with dementia (M=2.9, SD=1.9). 92 Clinically relevant differences in means were defined as 1.5 on the PES and 4 on the QUALID.…”

Section: Methods and Analysismentioning

confidence: 99%

Effects of the Namaste Care Family programme on quality of life of nursing home residents with advanced dementia and on family caregiving experiences: study protocol of a cluster-randomised controlled trial

Smaling

Joling²,

Ven

et al. 2018

BMJ Open

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IntroductionQuality of life of people with advanced dementia living in nursing homes is often suboptimal. Family caregivers can feel frustrated with limited contact with their relatives, which results in visits that are perceived as stressful and not very meaningful. Few psychosocial interventions are specifically developed for people with advanced dementia, and actively involve family caregivers or volunteers. Also, interventions usually stop when it becomes difficult for people to participate. The Namaste Care Family programme aims to increase the quality of life of people with advanced dementia, and improve family caregiving experiences through connecting to people and making them comfortable.Methods and analysisOur study will evaluate the effects of the Namaste Care Family programme on quality of life of people with advanced dementia living in nursing homes and family caregiving experiences using a cluster-randomised controlled trial. Longitudinal analyses will be performed taking into account clustering at the nursing home level. Both a cost-effectiveness and a cost-utility analysis from a societal perspective will be performed. We will modify the Namaste Care Family programme to increase family and volunteer involvement in ongoing and end-of-life care. Data collection involves assessments by family caregivers, nursing staff and elderly care physicians using questionnaires, and observations by the researchers at baseline and multiple times over 12 months. The last questionnaire will be sent up to month 24 after the death of the person with dementia. During semistructured interviews, the feasibility, accessibility and sustainability of the Namaste Care Family programme will be assessed.Ethics and disseminationThe study protocol is approved by the Medical Ethics Review Committee of the VU University Medical Center in Amsterdam (protocol no. 2016.399) and registered with the Nederlands Trial Register (NTR5692). The findings will be disseminated via publications in peer-reviewed journals, conference presentations and presentations for healthcare professionals where appropriate.Trial registration numberNTR5692.

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“…As the parietal lobe is involved in visuomotor integration, these patients may have impairments in visuomotor integration tasks. Several studies have found delayed hand response times and hand movement times towards visible targets [8,9,10] and towards remembered targets [25] in dementia patients. Also, dementia patients have a decreased ability to inhibit reflexive eye and hand movements [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies indicated that AD patients both respond slower to visual stimuli and show delayed hand movement times in manual reaching tasks, i.e. tasks where patients are required to make a reaching movement with the goal to manually touch targets, compared to neurologically healthy elderly [8,9,10], and compared to patients with other neurodegenerative etiologies [8]. These deficits are suspected to be caused by degenerating brain networks involved in the integration of cognitive and (visuo)motor functions, mainly in the parietal and frontal cortices [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…tasks where patients are required to make a reaching movement with the goal to manually touch targets, compared to neurologically healthy elderly [8,9,10], and compared to patients with other neurodegenerative etiologies [8]. These deficits are suspected to be caused by degenerating brain networks involved in the integration of cognitive and (visuo)motor functions, mainly in the parietal and frontal cortices [8,9,10]. Since accurate control of eye-hand coordinated movements are crucial for the safe and efficient execution of many IADL [11,12,13], we hypothesize that deficits in eye-hand coordinated movements may be an underlying cause for the loss of IADL function in aMCI and dementia patients.…”

Section: Introductionmentioning

confidence: 99%

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Delays in Manual Reaching Are Associated with Impaired Functional Abilities in Early Dementia Patients

Boer

Pel²,

Steen³

et al. 2015

Dement Geriatr Cogn Disord

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Background/Aims: Recent evidence shows that early dementia patients have deficits in manual reaching tasks. It is important to understand the impact of these functional disabilities on their quality of life. The aim of this study was to investigate if there is an association between manual reaching and measures of (instrumental) activities of daily living (IADL) in a group of patients with cognitive complaints. Methods: The manual reaching performance of 27 patients was assessed in detail with eye and hand tracking devices. Patients were divided into three groups based on self-reported loss of IADL function. Parameters describing hand response and movement times were compared between groups. Results: Patients with loss of IADL function in ≥1 domain had delayed hand response and hand movement times towards visible targets compared to patients with no loss of IADL function. Conclusion: Delays in manual reaching movements are related to the degree of loss of IADL function in early dementia patients.

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The Effect of Neurodegeneration on Visuomotor Behavior in Alzheimer’s Disease and Parkinson’s Disease

Cited by 20 publications

References 0 publications

Using synchronized eye and motion tracking to determine high-precision eye-movement patterns during object-interaction tasks

Using synchronized eye and motion tracking to determine high-precision eye-movement patterns during object-interaction tasks

Effects of the Namaste Care Family programme on quality of life of nursing home residents with advanced dementia and on family caregiving experiences: study protocol of a cluster-randomised controlled trial

Delays in Manual Reaching Are Associated with Impaired Functional Abilities in Early Dementia Patients

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