The effect of neighbor distance of magnetic nanoparticle clusters on magnetic resonance relaxation properties

Wang, Dan; Lin, Bin; Shen, Taipeng; Wu, Jun; Xia, Chunchao; Song, Bin; Ai, Hua

doi:10.1007/s11434-016-1107-x

Cited by 16 publications

(13 citation statements)

References 30 publications

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“…Communications 8112 www.angewandte.org Among them, introducing assemblies of magnetic nanoparticles is probably the most effective yet intriguing approach for enhancing the r 2 ,w hich increases with decreasing interparticle distance. [19] In our experiment, we found that the DL-Ve exhibited greatly enhanced r 2 activity compared with that of single JNPs (Figure 4e,f). The r 2 values of the DL-Ve 1( 405 AE 12.4 mm À1 s À1 )a nd DL-Ve2( 295 AE 7.2 mm À1 s À1 )a re about 7a nd 5t imes greater than that of single JNP (56 AE 4.2 mm À1 s À1 ), due to the strong magnetic dipole interaction of the Fe 3 O 4 NPs in the vesicular shell.…”

Section: Angewandte Chemiementioning

confidence: 53%

Double‐Layered Plasmonic–Magnetic Vesicles by Self‐Assembly of Janus Amphiphilic Gold–Iron(II,III) Oxide Nanoparticles

et al. 2017

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Janus nanoparticles (JNPs) offer unique features, including the precisely controlled distribution of compositions, surface charges, dipole moments, modular and combined functionalities, which enable excellent applications that are unavailable to their symmetrical counterparts. Assemblies of NPs exhibit coupled optical, electronic and magnetic properties that are different from single NPs. Herein, we report a new class of double-layered plasmonic-magnetic vesicle assembled from Janus amphiphilic Au-Fe O NPs grafted with polymer brushes of different hydrophilicity on Au and Fe O surfaces separately. Like liposomes, the vesicle shell is composed of two layers of Au-Fe O NPs in opposite direction, and the orientation of Au or Fe O in the shell can be well controlled by exploiting the amphiphilic property of the two types of polymers.

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Section: Angewandte Chemiementioning

confidence: 53%

Double‐Layered Plasmonic–Magnetic Vesicles by Self‐Assembly of Janus Amphiphilic Gold–Iron(II,III) Oxide Nanoparticles

et al. 2017

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“…23,24 In addition, interparticle interactions between IONPs can play dominant roles in the overall magnetic and hyperthermia properties of interacting IONPs (eg, clusters and concentrated ferrofluids). [25][26][27] The close proximity of multiple IONPs can affect the local dipole and anisotropic energy, resulting in an alteration of their magnetic susceptibility and heating efficiency. [28][29][30] Hence, several attempts have been made to modulate the interparticle interactions of IONPs to enhance the magnetic or hyperthermia characteristics.…”

Section: Introductionmentioning

confidence: 99%

Highly Optimized Iron Oxide Embedded Poly(Lactic Acid) Nanocomposites for Effective Magnetic Hyperthermia and Biosecurity

Ryu

Lee

Kim

et al. 2022

IJN

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Introduction: Iron oxide magnetic nanoparticles (IONPs) have attracted considerable attention for various biomedical applications owing to their ease of synthesis, strong magnetic properties, and biocompatibility. In particular, IONPs can generate heat under an alternating magnetic field, the effects of which have been extensively studied for magnetic hyperthermia therapy. However, the development of IONPs with high heating efficiency, biocompatibility, and colloidal stability in physiological environments is still required for their safe and effective application in biomedical fields. Methods: We synthesized magnetic IONP/polymer nanocomposites (MNCs) by embedding IONPs in a poly(L-lactic acid) (PLA) matrix via nanoemulsion. The IONP contents (Fe: 9-22 [w/w]%) in MNCs were varied to investigate their effects on the magnetic and hyperthermia performances based on their optimal interparticle interactions. Further, we explored the stability, cytocompatibility, biodistribution, and in vivo tissue compatibility of the MNCs. Results: The MNCs showed enhanced heating efficiency with over two-fold increase compared to nonembedded bare IONPs. The relationship between the IONP content and heating performance in MNCs was nonmonotonous. The highest heating performance was obtained from MNC2, which contain 13% Fe (w/w), implying that interparticle interactions in MNCs can be optimized to achieve high heating performance. In addition, the MNCs exhibited good colloidal stability under physiological conditions and maintained their heating efficiency during 48 h of incubation in cell culture medium. Both in vitro and in vivo studies revealed excellent biocompatibility of the MNC. Conclusion: Our nanocomposites, comprising biocompatible IONPs and PLA, display improved heating efficiency, good colloidal stability, and cytocompatibility, and thus will be beneficial for diverse biomedical applications, including magnetic hyperthermia for cancer treatment.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent magnetic resonance imaging contrast agents for disease diagnosis and therapy [1, 2]. They have been widely used in clinical applications such as identifying inflamed lesions of atherosclerosis to predict future risks and prognosis [3].…”

Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles promote vascular endothelial cells survival from oxidative stress by enhancement of autophagy

Duan

Jin

et al. 2019

Regenerative Biomaterials

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Dextran-coated superparamagnetic iron oxide nanoparticles (Dex-SPIONs) are excellent magnetic resonance imaging contrast agents for disease diagnosis and therapy. They can be delivered to target tissues mainly though vascular endothelium cells, which are major targets of oxidative stress. In cardiovascular cells, autophagy serves primarily on a pro-survival approach that protects the cells from oxidative stress even some autophagy inducers have been developed for adjuvant therapy of cardiovascular disorders. Our study demonstrated that the nanoparticles could be taken up by human umbilical vein endothelial cells (HUVECs) without causing obvious cytotoxicity but triggering autophagy. Furthermore, our results revealed that Dex-SPIONs could enhance HUVECs survival and reverse the reduction of nitric oxide secretion under the condition of H2O2 damage. However, these effects could be diminished by the autophagy inhibitor. In particular, we discovered that Dex-SPIONs evoked autophagy in HUVECs by reducing the phosphorylation of PRAS40, an upstream regulator of autophagy initiation. These results suggested that Dex-SPIONs functions as an autophagic-related antioxidant in HUVECs which may be utilized as an adjuvant therapy to cardiovascular disease associated with oxidative stress.

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The effect of neighbor distance of magnetic nanoparticle clusters on magnetic resonance relaxation properties

Cited by 16 publications

References 30 publications

Double‐Layered Plasmonic–Magnetic Vesicles by Self‐Assembly of Janus Amphiphilic Gold–Iron(II,III) Oxide Nanoparticles

Double‐Layered Plasmonic–Magnetic Vesicles by Self‐Assembly of Janus Amphiphilic Gold–Iron(II,III) Oxide Nanoparticles

Highly Optimized Iron Oxide Embedded Poly(Lactic Acid) Nanocomposites for Effective Magnetic Hyperthermia and Biosecurity

Iron oxide nanoparticles promote vascular endothelial cells survival from oxidative stress by enhancement of autophagy

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