The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial

Abstract

Objective: Osteoarthritis is a degenerative disease of the joints. Non-steroidal antiinflammatory drugs (NSAIDs) are being used for the treatment of osteoarthritis. However, their use is limited due to complications, such as gastrointestinal bleeding. Therefore, it is necessary to find alternative treatments for osteoarthritis. Recently, nanomicelle curcumin has been developed to increase the oral bioavailability of curcumin. The aim of this study was to evaluate the effect of nano curcumin on the alleviation of the symptoms of knee osteoarthritis patients. Methods: In this randomized, double-blind controlled trial, the intervention group was administered 40 mg of nanocurcumin capsule every 12 hours over a period of six weeks, and the control group received the placebo (similar components of nanomicelle curcumin capsules yet without curcumin). In the final analysis, 36 patients in the nanocurcumin group and 35 patients in the placebo group were enrolled. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was filled for patients in their first visit and at the end of six weeks. Differences were statistically significant at P-value < 0.05. Results: There were no significant differences between the two groups regarding gender, age, Kellgren score, and the duration of the disease before the intervention. A significant decrease was observed in the overall score, along with the scores of pain, stiffness and physical activity subscales of the WOMAC questionnaire in patients of the nano curcumin group compared with the placebo group. Conclusion: Nanocurcumin significantly improves the symptoms of osteoarthritis patients.

Prospective, Multicenter Evaluation of a Polyherbal Supplement alongside Standard-of-Care Treatment for Mild Knee Osteoarthritis

“…Moreover, adverse effects overall were significantly less frequent in the curcumin group (13% vs. 38%; p < 0.01). Other studies also confirmed the beneficial use of curcuminoids in knee OA management [ 16 , 17 ].…”

The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

“…The basic characteristics of each RCTs are shown in Belgium, Kertia et al 2012 [32] comes from Indonesia, and Nakagawa et al 2014 [36] comes from Japan. In addition, 3 RCTs come from India [20,[38][39], 3 RCTs come from Thailand [33,35,37], and 4 RCTs come from Iran [17,19,30,34]. These 15 RCTs involve a total of 1621 participants, and the scale of each RCT is 40-400 participants.…”

Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials

“…The nanodrug made from ginger produced a more significant reduction in pain than that reported by the control group to whom a 1% diclofenac gel was administered (Amorndoljai, Taneepanichskul, Niempoog, & Nimmannit, 2017). Nanocurcumin also reduced pain scores, stiffness, and physical activity subscales of patients with knee osteoarthritis compared to the control group that received placebo capsules (Hashemzadeh, Davoudian, Jaafari, & Mirfeizi, 2020). Nonsteroidal anti‐inflammatory drugs (NSAIDs), such as diclofenac, are standard pain treatments but can result in a range of side effects (Hewlings & Kalman, 2017).…”