The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows

Traş, Bünyamin; Dinç, Dursun Ali; Üney, Kamil

doi:10.15312/eurasianjvetsci.201436512

Cited by 6 publications

(6 citation statements)

References 20 publications

(21 reference statements)

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“…In the current study, the CR of cows was 100% for cows treated with the combined NAC following the 1 st services. The observed higher CR of cows in our study and those obtained in mares as affected by NAC treatment may be due to NAC does differences used in treatment (Tras et al, 2014).…”

Section: Advances In Animal and Veterinary Sciencescontrasting

confidence: 42%

“…In accordance with these findings, an IU infusion of a 3.3% solution of NAC in repeat breeder mares have indicated higher pregnancy rates of 81-85% (LeBlanc, 2012). However, the CR of NAC treated cows was 66.7% (Tras et al, 2014). In mares, oral (Witte et al, 2012) or IU (Melkus et al, 2012) treatment of NAC improved fertility rates.…”

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 90%

“…Previous studies have shown that, administration of NAC reduces plasma homocystine levels (Ventura et al, 1999) and the viscosity of mucus by separating disulfide bonds in mucous proteins, removing purulent or non-purulent secretions from the body (Tras et al, 2014). Also, NAC has properties as antioxidant, cytoprotective medium, and antiinflammatory agent (Tsai et al, 2010;Melkus et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Oral or Intrauterine N-Acetyl Cysteine Treatment as A Strategy for Improving the Reproductive Efficiency and Antioxidant Capacity of Lactating Cows

El-Nagar¹,

Wafa²,

Abdel-Khalek³

2022

AAVS

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This study aimed to determine the influence of N-Acetyl-Cysteine (NAC), as oral, intrauterine (IU) or oral plus IU administration at early postpartum period, on reproductive performance, antioxidant capacity, and health status of lactating cows. This study included 20 Friesian lactating cows (480±22.7 kg LBW, 2-4 parities and 4.5-6 years old). In day 15 postpartum, cows were divided into four groups, 5 cows/group. Cows in the 1 st group represented the control group without treatment (G1). In G2, cows were orally treated with 1.2 g NAC/100 kg BW for 7 days, while 100 ml of 2% NAC solution was infused intrauterine for 3 days for each cow in G3. Cows in G4 were received 0.6 g NAC/100 kg BW orally for 7 days and IU infused by 100 ml of 1% NAC solution for three days. Results showed that cows in G4 showed the highest values of RBCs, Hb, PCV, WBCs, lymphocytes, basophils, total antioxidant capacity, SOD, GSH, catalase, and conception rate, and the lowest values of AST and ALT, creatinine, MDA, TNFα, IFN-γ, IL2, IL6, days-open and number of inseminations per conception. In most postpartum days of all groups, serum P4 and E2 concentrations were in association with conception rate. In conclusion, the dual treatment of lactating cows on day 15 postpartum with 0.6 NAC/kg (orally for 7 days) plus 1% NAC (IU infusion for 3 days) may improve the reproductive efficiency, health performance, antioxidant enzymes, and inflammatory reaction during the postpartum period.

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Section: Advances In Animal and Veterinary Sciencescontrasting

confidence: 42%

Section: Advances In Animal and Veterinary Sciencesmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Oral or Intrauterine N-Acetyl Cysteine Treatment as A Strategy for Improving the Reproductive Efficiency and Antioxidant Capacity of Lactating Cows

El-Nagar¹,

Wafa²,

Abdel-Khalek³

2022

AAVS

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“…Other protocols that have been used for the treatment of metritis or clinical endometritis, such as intrauterine infusion of dextrose [94], ozone [95], or N-acetylcysteine combined with amoxicillin and clavulanic [96], have not been tested in cows with subclinical endometritis. Nevertheless, the effect of those substances is mainly antibacterial or mucolytic, whereas in SE there is no mucopurulent secretion and, in most cases, no pathogen bacteria.…”

Section: Treatment Of Subclinical Endometritismentioning

confidence: 99%

Subclinical Endometritis in Dairy Cattle

Arias¹,

Fernández²,

González³

et al. 2018

New Insights Into Theriogenology

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Subclinical endometritis is recognized as a cause of poor reproductive performance in dairy cows. Inflammation of the endometrium persisting after postpartum uterine involution has been related with prolonged calving-conception intervals and low fertility in dairy cows. The subclinical nature of this condition makes it necessary in the use of endometrial cytology or biopsy for diagnosing it. There are some controversies among authors in relation to the postpartum period from which a physiological endometrial inflammation should be considered a pathological subclinical endometritis. Therefore, depending on the sampling period after calving, different studies establish a different degree of polymorphonuclear leukocyte infiltration as cutoff point to diagnose subclinical endometritis. Controversies also exist regarding the pathogenesis of the disease and its consequences on the fertility of dairy cattle. The aim of this chapter was to review the current knowledge on this uterine pathology.

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“…NAC's antioxidant and anti-inflammatory properties makes it a promising therapeutic agent for diseases in which oxidative stress is involved in the diseases' etiology and progression (Ténorio et al, 2021). Examples of these diseases include diabetes, cancer, neurological disorders, hypertension, pulmonary, inflammatory, cardiovascular and infectious diseases in humans, as well as weaning disorders, porcine epidemic diarrhea, endometritis and mastitis in livestock (Brieger et al, 2012;Birben et al, 2012;Mishra and Jha 2019;Wang et al, 2017;Tras et al, 2014;Yang et al, 2016;Hou et al, 2015). Furthermore, NAC has a wellestablished safety profile and is relatively inexpensive (Ténorio et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

N-Acetylcysteine (NAC) and its Immunomodulatory Properties

Tieu

Karrow

Mallard

et al. 2022

SURG

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N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine has been widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s and the 1980s respectively. NAC possesses antioxidant, cytoprotective, anti-inflammatory, antimicrobial and mucolytic properties, making it a promising therapeutic agent for a wide range of diseases in both humans and livestock in which oxidative stress and inflammation plays a major role in the onset and progression of the disease. NAC’s primary role is to replenish glutathione (GSH) stores; the master antioxidant in all tissues, however it can also reduce levels of pro-inflammatory tumor necrosis factor-alpha (TNF-) and interleukins (IL-6 and IL-1), inhibit formation of microbial biofilm, destroy biofilms, and break down disulfide bonds between mucin molecules. Many experimental studies have been conducted on the use of NAC in addressing a wide range of pathological conditions, however, its effectiveness in addressing different pathological conditions in clinical trials remains limited and studies often have conflicting results. The purpose of this review is to provide a concise overview of promising NAC usages for treatment of different human and livestock disorders.

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The effect of N-acetylcysteine on the treatment of clinical endometritis and pregnancy rate in dairy cows

Cited by 6 publications

References 20 publications

Oral or Intrauterine N-Acetyl Cysteine Treatment as A Strategy for Improving the Reproductive Efficiency and Antioxidant Capacity of Lactating Cows

Oral or Intrauterine N-Acetyl Cysteine Treatment as A Strategy for Improving the Reproductive Efficiency and Antioxidant Capacity of Lactating Cows

Subclinical Endometritis in Dairy Cattle

N-Acetylcysteine (NAC) and its Immunomodulatory Properties

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