The effect of Myo-Inositol supplement on molecular regulation of folliculogenesis, steroidogenesis, and assisted reproductive technique outcomes in patients with polycystic ovarian syndrome

Tabatabaie, Maryam; Amiri, Sadegh; Jahromi, Masoumeh Golestan; Sene, Azadeh Akbari; Zandieh, Zahra; Mehdizadeh, Mehdi; Amjadi, Fatemehsadat

doi:10.1007/s11033-021-06833-9

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…of retrieved oocytes among PCOS cases and healthy controls. However, they found that the PCOS subgroup treated with inositol supplement had more M2 oocytes, higher fertilization rates, and better embryo quality, as well as lower StAR gene expression in cumulus cells [23].…”

Section: Tabatabaie Et Al Study Confirmed the Presence Of Star Gene I...mentioning

confidence: 97%

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The effect of adipose tissue StAR gene expression on ICSI among Polycystic Ovarian Syndrome cases and matched controls: a case-control study

Helmi¹,

Nori²

2024

Ital J Gynaecol Obstet

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Objective. steroidogenesis is vital for reproduction and fertility; it is governed by the acute regulatory protein gene (StAR). Earlier work discussed a different StAR expression in the adipose tissue (AT) of pregnant polycystic ovarian syndrome (PCOS) women. This study examined the correlation of StAR expression levels in AT of PCOS women to various parameters of intracytoplasmic sperm injection (ICSI) compared to those without. Patients and methods.A case-control study recruited 40 infertile women who had successful ICSI cycles into 2 groups: 20/40 cases and 20/40 non-PCOS cases; both groups were age and body mass index-matched for scheduled elective cesarean section. A sample of anterior abdominal wall AT was taken for a real-time PCR StAR gene expression. ICSI parameters, including hormonal, ultrasonic, stimulation drug doses and duration, and the outcome, were all retrospectively recorded and correlated with StAR gene expression.Results. StAR gene folding was higher among PCOS-pregnant women (2.545 ±1.58 vs. 1.00 ±0.0), P-value< 0.023. estradiol hormone was correlated to StAR gene; -0.39, P<0.05. The total doses of recombinant follicle-stimulating hormone and human menopausal gonadotropin had significant correlations to StAR gene r= (-0.39, 0.60), P-value of (0.049, 0.005), respectively.Conclusions. The significant association of StAR gene expression with stimulation drug doses suggests a clinical application, as it can reduce ovarian hyperstimulation syndrome and overall expense, which makes ICSI safer and more accessible to infertile couples. Women with PCOS present challenges in ICSI, and thus careful balance must be adjusted.

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Section: Tabatabaie Et Al Study Confirmed the Presence Of Star Gene I...mentioning

confidence: 97%

“…PCOS women who undergo IVF programs. Their study opens a new interventional horizon for PCOS; the genetic expression of StAR gene was reduced in the PCOS sub-group that received myo-inositol supplement compared to the group without [23].…”

Section: Tabatabaie Et Al Study Confirmed the Presence Of Star Gene I...mentioning

confidence: 98%

The effect of adipose tissue StAR gene expression on ICSI among Polycystic Ovarian Syndrome cases and matched controls: a case-control study

Helmi¹,

Nori²

2024

Ital J Gynaecol Obstet

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show abstract

When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments

Unfer,

Kandaraki,

Pkhaladze

et al. 2024

Endocrine and Metabolic Science

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Nutritional supplements and IVF: an evidence-based approach

Hart

2024

Reproductive BioMedicine Online

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The effect of Myo-Inositol supplement on molecular regulation of folliculogenesis, steroidogenesis, and assisted reproductive technique outcomes in patients with polycystic ovarian syndrome

Cited by 8 publications

References 37 publications

The effect of adipose tissue StAR gene expression on ICSI among Polycystic Ovarian Syndrome cases and matched controls: a case-control study

The effect of adipose tissue StAR gene expression on ICSI among Polycystic Ovarian Syndrome cases and matched controls: a case-control study

When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments

Nutritional supplements and IVF: an evidence-based approach

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