Nutritional supplements and IVF: an evidence-based approach

Hart, Roger J.

doi:10.1016/j.rbmo.2023.103770

Cited by 2 publications

(2 citation statements)

References 71 publications

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“…While there is current interest for adjuvant therapies to improve reproductive outcomes, such as micronutrient supplementation, in the context of assisted reproductive treatments, it has been reported that the best strategy for improving reproductive outcomes is adherence to the Mediterranean diet [57,58]. Part of this effect may be due to the fact that this diet is associated with higher concentrations of micronutrients [57].…”

Section: Discussionmentioning

confidence: 99%

“…Part of this effect may be due to the fact that this diet is associated with higher concentrations of micronutrients [57]. In addition, the use of dehydroepiandrosterone, co-enzyme Q10, melatonin, and essential fatty acids may be beneficial in some situations [58]. Although it has been reported that subfertile women have low concentrations of essential trace elements [2,[5][6][7][8] and that their supplementation may help to improve reproductive outcomes [5,7], in view of our results, this supplementation should only be prescribed in cases of deficiency of a particular trace element and monitored by a health care professional, as higher concentrations may be counterproductive to reproductive outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer

Gonzalez-Martin,

Palomar,

Perez-Deben

et al. 2024

Cells

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Essential trace elements are micronutrients whose deficiency has been associated with altered fertility and/or adverse pregnancy outcomes, while surplus may be toxic. The concentrations of eight essential trace elements were measured using inductively coupled mass spectrometry (ICP-MS) and assessed with respect to clinical in vitro fertilization (IVF) outcomes in a population of 51 women undergoing IVF with intracytoplasmic sperm injection (ICSI), pre-implantation genetic screening for aneuploidy (PGT-A), and single frozen euploid embryo transfer (SET/FET). Specifically, copper (Cu), zinc (Zn), molybdenum, selenium, lithium, iron, chromium, and manganese were quantified in follicular fluid and whole blood collected the day of vaginal oocyte retrieval (VOR) and in urine collected the day of VOR and embryo transfer. We found that the whole blood Cu/Zn ratio was significantly associated with superior responses to ovarian stimulation. Conversely, the whole blood zinc and selenium concentrations were significantly associated with poor ovarian response outcomes. Higher levels of whole blood zinc and selenium, urinary selenium, lithium, and iron had significant negative associations with embryologic outcomes following IVF. Regarding clinical IVF outcomes, higher urinary molybdenum concentrations the day of VOR were associated with significantly lower odds of implantation and live birth, while higher urinary Cu/Mo ratios on the day of VOR were associated with significantly higher odds of implantation, clinical pregnancy, and live birth. Our results suggest that essential trace element levels may directly influence the IVF outcomes of Spanish patients, with selenium and molybdenum exerting negative effects and copper-related ratios exerting positive effects. Additional studies are warranted to confirm these relationships in other human populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer

Gonzalez-Martin,

Palomar,

Perez-Deben

et al. 2024

Cells

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Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

Garmendia,

De Sanctis,

Hajdúch

et al. 2024

Microorganisms

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Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, and gut microbiota may play a role in RPL. A decrease in the quantity of Lactobacillus crispatus in local microbiota has been associated with an increase in local (vaginal and endometrial) inflammatory response and immune cell activation that leads to pregnancy loss. The inflammatory response may be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures and metabolites produced by microbiota could be involved in immune cell modulation and may be responsible for immune cell activation and molecular mimicry. Gut microbiota metabolic products may increase the amount of circulating pro-inflammatory lymphocytes, which, in turn, will migrate into vaginal or endometrial tissues. Local pro-inflammatory Th1 and Th17 subpopulations and a decrease in local Treg and tolerogenic NK cells are accountable for the increase in pregnancy loss. Local microbiota may modulate the local inflammatory response, increasing pregnancy success. Analyzing local and gut microbiota may be necessary to characterize some RPL patients. Although oral supplementation of probiotics has not been shown to modify vaginal or endometrial microbiota, the metabolites produced by it may benefit patients. Lactobacillus crispatus transplantation into the vagina may enhance the required immune tolerogenic response to achieve a normal pregnancy. The effect of hormone stimulation and progesterone to maintain early pregnancy on microbiota has not been adequately studied, and more research is needed in this area. Well-designed clinical trials are required to ascertain the benefit of microbiota modulation in RPL.

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Nutritional supplements and IVF: an evidence-based approach

Cited by 2 publications

References 71 publications

Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer

Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer

Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

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