The effect of music on delirium, pain, sedation and anxiety in patients receiving mechanical ventilation in the intensive care unit

Erbay, Öznur; Yıldırım, Yasemin; Aykar, Fisun Şenuzun; Kahveci, Ferda

doi:10.1016/j.iccn.2022.103348

Cited by 15 publications

(14 citation statements)

References 26 publications

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“…[25] Therefore, how to effectively prevent and reduce the incidence of delirium has become a hot topic of clinical research. Previously published RCTs on the effects of music therapy on delirium in patients receiving mechanical ventilatory support in the ICU have reached different conclusions [11,[15][16][17] caused by that these studies were limited by small sample sizes. To overcome these limitations, we will perform a high-quality systematic review and meta-analysis to assess the effect of music therapy on delirium in patients receiving mechanical ventilatory support in the ICU.…”

Section: Discussionmentioning

confidence: 99%

“…[3,13,14] The ability of music therapy to improve delirium in patients receiving mechanical ventilatory support in the ICU is currently controversial. [11,[15][16][17] Therefore, we will perform a systematic review and meta-analysis to investigate the effect of music therapy on delirium in patients receiving mechanical ventilatory support in the ICU.…”

Section: Introductionmentioning

confidence: 99%

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The effect of music therapy on delirium in patients receiving mechanical ventilatory support in the Intensive Care Unit: A protocol for systematic review and meta-analysis

Zhou

Qi³

et al. 2023

Medicine

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Background: Delirium is a very common sick syndrome in patients receiving mechanical ventilatory support in the Intensive Care Unit (ICU). Music therapy is a promising non-pharmacological intervention. However, its effect on the duration, incidence and severity of delirium is unknown. So we will perform a systematic review and meta-analysis to evaluate the effect of music therapy on delirium in patients receiving mechanical ventilatory support in the ICU. Methods: This systematic review was registered in the PROSPERO. We will follow the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocol to accomplish the systematic review protocol. Searches of PubMed, EMbase, the Cochrane library, CBM, CNKI and Wanfang databases will be conducted through computer to collect randomized controlled trials (RCTs) on the effects of music therapy on delirium in patients receiving mechanical ventilatory support in the ICU. The search time will be all from database establishment to April 2023. Two evaluators will independently screen the literature, extract information and evaluate the risk of bias of included studies, then data analysis will be performed using Stata 14.0 software. Results: The results of this systematic review and meta-analysis will be publicly available and published in a peer-reviewed journal. Conclusion: This study will provide evidence-based medical evidence for music therapy to control delirium in patients receiving mechanical ventilatory support in the ICU.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of music therapy on delirium in patients receiving mechanical ventilatory support in the Intensive Care Unit: A protocol for systematic review and meta-analysis

Zhou

Qi³

et al. 2023

Medicine

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“…4,19,27 Furthermore, music therapy has been shown to physiologically reduce stress and anxiety, as well as reduce sedation and delirium severity in mechanically ventilated patients, suggesting an interplay between auditory processing, neuroinflammation, and deliriogenic neurotransmission. [28][29][30] Intermittent loud noises presumptively affect sleep quality and quantity, which we know to be diminished in pediatric critical illness. 14,15,31,32 Although limited by a small study size, Gregory et al showed a trend toward lower median sleep time for delirious patients than those who were not delirious.…”

Section: Discussionmentioning

confidence: 99%

Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU

Greenfield

Karam

O'Meara

2023

J Pediatr Intensive Care

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The purpose of this study was to evaluate the association between sound and light variables and development of delirium in pediatric intensive care unit (PICU) patients within the subsequent 3 days. Light and sound were continuously measured, and patient-specific data were collected daily. Outcomes included presence of delirium, determined by Cornell Assessment of Pediatric Delirium (CAPD) score ≥ 9 on at least 1 day, and development of delirium in the subsequent 3 days. One hundred and forty-two patients were enrolled, totaling 896 study days. Delirium prevalence was 31%. Neurologic diagnosis, younger age, longer PICU stay, restraints, benzodiazepines, opiate infusion, and dexmedetomidine were associated with delirium. Nighttime sound peaks (>70 and >80 dB) were not associated with delirium (p = 0.94 and 0.36, respectively). Light intensity during midday hours (12:00, 1:00, 2:00 pm) was not associated with the development of delirium (p=0.93, 0.81, 0.83, respectively), nor was maximum light at night, difference between maximum daytime and nighttime light, or between maximum and minimum daytime light (p = 0.15, 0.46, and 0.96, respectively). When adjusting for covariables, none of the sound or light variables was associated with delirium. Despite increasing awareness of pediatric delirium, data surrounding modifiable risk factors and concrete treatment strategies are lacking. We found no significant association between light or sound and development of delirium in PICU patients. However, there was little difference between daytime and nighttime light and sound, which may have impacted findings. As the etiology of delirium is multifactorial and potentially different for individual patients, targeted light/dark cycles warrant further study as they relate to delirium and critical illness.

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“…The effect of this technique on pain perception in LIS and DoC patients has not, to our knowledge, been studied yet. However, studies carried out in other patient populations have shown interesting effects (by reducing anxiety for instance) which suggest that this may be an interesting avenue to investigate in future research ( Lin et al, 2020 ; Santiváñez-Acosta et al, 2020 ; Dallı et al, 2022 ; Seyffert et al, 2022 ).…”

Section: Reflections and Future Directionsmentioning

confidence: 99%

Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review

Bonin¹,

Szymkowicz²,

Bonhomme³

et al. 2023

Front. Syst. Neurosci.

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The assessment and management of pain and nociception is very challenging in patients unable to communicate functionally such as patients with disorders of consciousness (DoC) or in locked-in syndrome (LIS). In a clinical setting, the detection of signs of pain and nociception by the medical staff is therefore essential for the wellbeing and management of these patients. However, there is still a lot unknown and a lack of clear guidelines regarding the assessment, management and treatment of pain and nociception in these populations. The purpose of this narrative review is to examine the current knowledge regarding this issue by covering different topics such as: the neurophysiology of pain and nociception (in healthy subjects and patients), the source and impact of nociception and pain in DoC and LIS and, finally, the assessment and treatment of pain and nociception in these populations. In this review we will also give possible research directions that could help to improve the management of this specific population of severely brain damaged patients.

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The effect of music on delirium, pain, sedation and anxiety in patients receiving mechanical ventilation in the intensive care unit

Cited by 15 publications

References 26 publications

The effect of music therapy on delirium in patients receiving mechanical ventilatory support in the Intensive Care Unit: A protocol for systematic review and meta-analysis

The effect of music therapy on delirium in patients receiving mechanical ventilatory support in the Intensive Care Unit: A protocol for systematic review and meta-analysis

Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU

Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review

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