The Effect of Muscular Exercise and Hypoglycemia on the Plasma Level of 17-Hydroxysteroids in Normal Adults and in Patients With the Adrenogenital Syndrome

Staehelin, D; Labhart, A.; Froesch, R; Kägi, H. R.

doi:10.1530/acta.0.0180521

Cited by 22 publications

(17 citation statements)

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“…Rivoire et al (1953) found prolonged (1.5±2.5 h) intense exercise decreased the excretion of urinary 17-hydroxycorticoids. These ®ndings were later con®rmed in other human studies involving prolonged exercise (an initial increase in blood corticosteroid concentration was followed by decreases; Staehelin et al 1955;Viru et al 1973). Animal experiments also demonstrated similar ®ndings; that is, blood concentrations of glucocorticoids increased after short-term and decreased after prolonged exercise lasting several hours (KoÄ rge et al 1974;Viru and A È kke 1969).…”

Section: Introductionmentioning

confidence: 63%

“…These above ®ndings were dismissed as primarily aberrations of the less speci®c methods for hormone analysis employed at the time of the studies (i.e. colorometric and¯uoro-metric assays, KoÄ rge et al 1974;Staehelin et al 1955;Viru and A È kke 1969;Viru et al 1973), especially after the advent of the highly speci®c and precise immunoassay methods.…”

Section: Introductionmentioning

confidence: 99%

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Influence of prolonged continuous exercise on hormone responses to subsequent exercise in humans

et al. 2001

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This study examined the possibility that fatigue may modify the hormone responses to exercise. A group of 12 endurance trained athletes ran for 2 h (blood lactate concentrations of approximately 2 mmol x l(-1)) in order to induce fatigue. The subjects exercised for 10 min at 70% maximal oxygen uptake before (1st test) and after (2nd test) the 2 h run to assess hormone responsiveness. A 1 min anaerobic power test was performed to assess muscle power. Cortisol, growth hormone, testosterone and insulin concentrations were determined before and after the 1st and 2nd tests. The 1st test resulted in increases in concentrations (P < 0.05) of cortisol and growth hormone, a decrease in insulin concentration (P<0.01) and no change in testosterone concentration. The 2 h run caused decreases of insulin, increases of growth hormone concentration and variable responses in the concentrations of cortisol and testosterone. The 2nd test decreased insulin concentration further (P < 0.05), but responses of the concentrations of testosterone, growth hormone and cortisol were variable. In 6 subjects (group A) cortisol displayed an increase [mean (SD)] from baseline concentrations [+ 304.0 (60.0) nmol x l(-1)], while in the other 6 subjects (group B) a decrease or no change was seen [+ 3.1 (5.3) nmol x l(-1), between groups, P<0.05]. Growth hormone concentration was substantially higher in group A [+ 14.7 (4.8) ng x ml(-1)] than group B [+ 6.0 (2.9) ng x ml(-1)] following the 2nd test. In group A anaerobic muscle power was higher, while in group B it was lower, after the 2 h run than before the 2 h run (P < 0.05). The findings suggest that fatigue from prolonged endurance activity may introduce a resetting in the pituitary-adrenocortical component of the endocrine system, expressed either by intensified or by suppressed endocrine functions.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Influence of prolonged continuous exercise on hormone responses to subsequent exercise in humans

et al. 2001

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“…Plowever, the results of this study show that the increase in the corticoid content of the adrenal is not necessarily accompanied by an aug¬ mented concentration in blood corticoids. Probably, this discrepancy is due to an enhanced utilization of the blood corticoids during muscular work, as shown by Ingle (1952), Staehelin et al (1955) and Hill et al (1956). During continuous muscular work lasting until exhaustion the rate of corticoid biosynthesis, evidently began to decrease.…”

Section: Discussionmentioning

confidence: 98%

“…The increase in the urinary excretion (Rivoire et al 1953;Viru 1962 and the concentration (Staehelin et al 1955) of the corticoids in the blood during the first period of the long-lasting exercise is obviously con¬ firmation of this. Plowever, the results of this study show that the increase in the corticoid content of the adrenal is not necessarily accompanied by an aug¬ mented concentration in blood corticoids.…”

Section: Discussionmentioning

confidence: 99%

“…Usually, during long-lasting exercise, a decrease in the excretion (Rivoire et al 1953;Thorn et al 1953;Bugard et al 1961) and in the blood concentration of the corticoids (Stachelin et al 1955;Cornil et al 1965) is observed and this is considered to be connected with fatigue. The decreased excretion and corticoids concentration in the plasma is preceded by a period of augmented excretion (Rivoire et al 1953;Viru 1962Viru , 1965a and raised blood concentration (Staehelin et al 1955).…”

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confidence: 99%

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Effects of Muscular Work on Cortisol and Corticosterone Content in the Blood and Adrenals of Guinea Pigs

Viru

Äkke

1969

Acta Endocrinologica

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The cortisol and corticosterone content was determined fluorometrically in the blood and in the adrenals of guinea pigs. After three 5-minute\x=req-\ swimming sets the corticoid content increased in the adrenals, but remained unchanged in the blood. After 5-minute-swimming sets repeated until exhaustion, the adrenal corticoid content did not differ from the level of the control group. The blood cortisol content, however, fell significantly. The blood corticosterone content did not change. If before the swimming sets 4 IU of corticotrophin were administered, the cortisol content both in the adrenals and blood at the point of exhaustion was somewhat higher than in the control group. The decrease in blood corticoid concentration during long-lasting muscular work is due to insufficient stimulation of the adrenocortical activity. It has been suggested that the inhibition of the stimulation of the adrenocortical activity is one manifestation of a general defence reaction, against the fatal depletion of the resources of the organism.Determinations of the adrenocortical hormones and their metabolites in urine and blood during muscular exercise have not given constant results. Usually, during long-lasting exercise, a decrease in the excretion (Rivoire et al. 1953;Thorn et al. 1953;Bugard et al. 1961) and in the blood concentration of the corticoids (Stachelin et al. 1955;Cornil et al. 1965) is observed and this is considered to be connected with fatigue. The decreased excretion and corticoids concentration in the plasma is preceded by a period of augmented excretion

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Effect of Muscular Exercise on Day-Time Variations of Plasma Cortisol and Glucose

Follénius¹,

Brandenberger²

1975

Metabolic Adaptation to Prolonged Physical Exercise

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The Effect of Muscular Exercise and Hypoglycemia on the Plasma Level of 17-Hydroxysteroids in Normal Adults and in Patients With the Adrenogenital Syndrome

Cited by 22 publications

References 0 publications

Influence of prolonged continuous exercise on hormone responses to subsequent exercise in humans

Influence of prolonged continuous exercise on hormone responses to subsequent exercise in humans

Effects of Muscular Work on Cortisol and Corticosterone Content in the Blood and Adrenals of Guinea Pigs

Effect of Muscular Exercise on Day-Time Variations of Plasma Cortisol and Glucose

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