The effect of monaural middle ear destruction on response properties of neurons in the auditory midbrain of juvenile and adult mice

Jen, Philip H.‐S.; Xu, Li

doi:10.1016/j.brainres.2006.01.055

Cited by 2 publications

(1 citation statement)

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“…Characteristic frequencies ranged from 14-40 kHz ( Fig. 7B), with a mean of 25.8 ± .5 kHz, and increased with recording depth, as reported previously for Mexican free-tailed bats and other mammalian species (for example, Casseday and Covey 1992;Jen and Xu 2006;Zweirs et al 2004). Average first spike latencies ranged from 7.6 ms to 41.1 ms after stimulus onset, with a mean of 19.8 ± .57ms.…”

Section: Resultssupporting

confidence: 82%

The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons

Hall

Hurley

2007

Hearing Research

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Local direct application of the neuromodulator serotonin strongly influences auditory response properties of neurons in the inferior colliculus (IC), but endogenous stores of serotonin may be released in a distinct spatial or temporal pattern. To explore this issue, the serotonin releaser fenfluramine was iontophoretically applied to extracellularly recorded neurons in the IC of the Mexican free-tailed bat (Tadarida brasiliensis). Fenfluramine mimicked the effects of serotonin on spike count and first spike latency in most neurons, and its effects could be blocked by co-application of serotonin receptor antagonists, consistent with fenfluramine-evoked serotonin release. Responses to fenfluramine did not vary during single applications or across multiple applications, suggesting that fenfluramine did not deplete serotonin stores. A predicted gradient in the effects of fenfluramine with serotonin fiber density was not observed, but neurons with fenfluramine-evoked increases in latency occurred at relatively greater recording depths compared to other neurons with similar characteristic frequencies. These findings support the conclusion that there may be spatial differences in the effects of exogenous and endogenous sources of serotonin, but that other factors such as the identities and locations of serotonin receptors are also likely to play a role in determining the dynamics of serotonergic effects.

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Section: Resultssupporting

confidence: 82%