Auditory processing disorder (APD)—Potential contribution of mouse research

Moore, David R.

doi:10.1016/j.brainres.2006.01.108

Cited by 24 publications

(17 citation statements)

References 40 publications

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“…The fact that certain auditory processing deWcits appear to be comorbid with a variety of learning and language disabilities in children, and that auditory processing skills degrade in the elderly, has stimulated research in the etiology of auditory processing. Animal models are contemplated for investigating auditory processing abilities, and for more clearly separating the cognitive contributions to performance on tests of these abilities (Liu 2006;Moore 2006). Insight into the relative contribution of heredity and environment to the normal variation in these skills is a prerequisite to an understanding of the causes of auditory processing disorders.…”

Section: Discussionmentioning

confidence: 99%

A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait

Morell

Brewer

et al. 2007

Hum Genet

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We administered tests commonly used in the diagnosis of auditory processing disorders (APDs) to twins recruited from the general population. We observed significant correlations in test scores between co-twins. Our analyses of test score correlations among 106 MZ and 33 DZ twin pairs indicate that dichotic listening ability is a highly heritable trait. Dichotic listening is the ability to identify and distinguish different stimuli presented simultaneously to each ear. Deficits in dichotic listening skills indicate a lesion or defect in interhemispheric information processing. Such defects or lesions can be prominent in elderly listeners, language-impaired children, stroke victims, and individuals with PAX6 mutations. Our data indicates that other auditory processing abilities are influenced by shared environment. These findings should help illuminate the etiology of APDs, and help to clarify the relationships between auditory processing abilities and learning/language disorders associated with APDs.

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Section: Discussionmentioning

confidence: 99%

A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait

Morell

Brewer

et al. 2007

Hum Genet

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“…Despite the several researches corroborating the temporal processing theory (5)(6)(7)(8)(9) , there are controversies about these findings due to the difficulty in establishing a causal relation between the phonological processing and the auditory temporal processing (10,11) , besides the great individual variation in children's performance for this kind of auditory test (4,12,13) . Furthermore, there is the difficulty to evidence these disorders only by behavioral tests (14) .…”

Section: Introductionmentioning

confidence: 99%

Processamento auditivo (central) em crianças com dislexia: avaliação comportamental e eletrofisiológica

Oliveira

Murphy

Schochat

2013

CoDAS

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OBJETIVO: Comparar o desempenho de crianças com dislexia e grupo controle em testes de processamento auditivo e P300. MÉTODOS: Vinte e dois indivíduos com dislexia (grupo estudo) e 16 indivíduos com desenvolvimento considerado típico (grupo controle) participaram do estudo. Todos os indivíduos foram submetidos aos testes de processamento auditivo (Teste Padrão de Frequência, Dicótico de Dígitos e Fala com Ruído) e o P300. RESULTADOS: Em relação aos testes comportamentais, houve diferença para o Teste Padrão de Frequência e para a orelha esquerda no Teste Dicótico de Dígitos, sendo que o grupo estudo apresentou pior desempenho em ambos os testes. Para o P300, houve diferença entre os grupos em relação aos valores absolutos de amplitude e latência, mas esta não foi significativa. CONCLUSÃO: Os achados sugerem que crianças com dislexia apresentam alteração das habilidades auditivas de processamento temporal e figura-fundo, o que foi evidenciado por meio de testes comportamentais de processamento auditivo. Não houve diferença em relação aos desempenhos de ambos os grupos para o P300.

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“…b Submicron deflections imposed onto the stereociliary bundle of an outer hair cell in the rat cochlea (postnatal day 8, at 20°C, 1.5 mM calcium) caused inward membrane currents that activated and deactivated rapidly. In addition, the mechanosensitive current showed both fast and slow rates of decay (adaptation) during the sustained deflection (a from Crawford and Fettiplace [22], with permission; b from Kennedy et al [42], with permission) of mammals, including topics ranging from age-related hearing loss [59] to central processing disorders [56].…”

Section: Hair Bundle Adaptationmentioning

confidence: 99%

Auditory transduction in the mouse

Grant

Fuchs

2007

Pflugers Arch - Eur J Physiol

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The sensory hair cells of the mammalian cochlea transduce acoustic stimuli into auditory nerve activity. The biomechanical and molecular details of hair cell mechanotransduction are being acquired at an ever-finer level of resolution. In this review, we discuss how selected mouse mutants and transgenic models have contributed to, and will continue to shape, our understanding of the molecular basis of hair cell mechanotransduction. Functional and structural discoveries made originally in hair cells of nonmammalian vertebrates have been further pursued in the mouse inner ear, where transgenic manipulation can be applied to test molecular mechanisms. Additional insights have been obtained from mice bearing mutations in genes underlying deafness in humans. Taken together, these studies emphasize the elegance of mechanotransduction, enlarge the team of molecular players, and begin to reveal the remarkable adaptations that provide the sensitivity and temporal resolution required for mammalian hearing.

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Auditory processing disorder (APD)—Potential contribution of mouse research

Cited by 24 publications

References 40 publications

A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait

A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait

Processamento auditivo (central) em crianças com dislexia: avaliação comportamental e eletrofisiológica

Auditory transduction in the mouse

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