The effect of mixing on gentamicin release from polymethylmethacrylate bone cements

Neut, Daniëlle; Belt, Hilbrand van de; Horn, J.R. van; Mei, Henny C. van der; Busscher, Henk J.

doi:10.1080/00016470310018180

Cited by 97 publications

(66 citation statements)

References 16 publications

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“…Our findings differ from those of Lewis and colleagues in that we did not see the difference between hand-stirred or bowl-mixed methods (similar to commercial powder mixer) and commercial pre-mixed that Lewis reported [5]. Neut et al [7] found that using vacuum during mixing had a minor effect on elution using a mechanical mixing method similar to the bowl-mix method in this study. Lewis et al [5] and Neut et al [7] both analyzed their data with Student t tests across the single factor of mixing within single batches whereas we analyzed using both cement type and mixing method with ANOVA and Tukey's allowing estimates of batch to batch variation.…”

Section: Discussioncontrasting

confidence: 99%

“…Neut et al [7] found that using vacuum during mixing had a minor effect on elution using a mechanical mixing method similar to the bowl-mix method in this study. Lewis et al [5] and Neut et al [7] both analyzed their data with Student t tests across the single factor of mixing within single batches whereas we analyzed using both cement type and mixing method with ANOVA and Tukey's allowing estimates of batch to batch variation.…”

Section: Discussionmentioning

confidence: 47%

“…Lewis et al [5] reported inferior gentamicin release from hand-stirred and commercial powder-mixer formulations compared to commercially pre-mixed samples of cement. Neut et al [7] reported similar elution with manual mixing in a commercial vacuum mixing cartridge with and without vacuum applied. None of the studies evaluated the homogeneity of antibiotic throughout the ALBC for any mixing method.…”

Section: Introductionmentioning

confidence: 87%

“…Studies comparing the elution of antibiotics from different hand-mixing methods and commercially premixed ALBC [4,5,7], report both similarity and differences of elution from different formulations of ALBC. Lewis et al [5] reported inferior gentamicin release from hand-stirred and commercial powder-mixer formulations compared to commercially pre-mixed samples of cement.…”

Section: Introductionmentioning

confidence: 99%

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Hand-mixed and Premixed Antibiotic-loaded Bone Cement Have Similar Homogeneity

McLaren

Nugent

Economopoulos

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Since low-dose antibiotic-loaded bone cement (ALBC) was approved by the FDA for second-stage reimplantation after infected arthroplasties in 2003, commercially premixed low-dose ALBC has become available in the United States. However, surgeons continue to mix ALBC by hand. We presumed hand-mixed ALBC was not as homogeneous as commercially premixed ALBC. We assessed homogeneity by determining the variation in antibiotic elution by location in a batch, from premixed and hand-mixed formulations of low-dose ALBC. Four handmixed methodologies were used: (1) suspension-antibiotic powder in the liquid monomer; (2) no-mix-antibiotic powder added but not mixed with the polymer powder before adding monomer; (3) hand-stirred-antibiotic powder stirred into the polymer powder before the monomer was added; and (4) bowl-mix-antibiotic powder mixed into polymer powder using a commercial mixing bowl before the monomer was added. Antibiotic elution was measured using the Kirby-Bauer bioassay. None of the mixing methods had consistently dissimilar homogeneity of antibiotic distribution from the others. Based upon our data we conclude hand-mixed low-dose ALBC is not less homogeneous than commercially premixed formulations.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hand-mixed and Premixed Antibiotic-loaded Bone Cement Have Similar Homogeneity

McLaren

Nugent

Economopoulos

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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“…6,10 The amount of antibiotic released from cement showed an exponential decline after day one of implantation. [11][12][13] Villanueva-Martínez reported in their 2013 review that elution typically occurs in three phases based on Lewis's data. 3,14 This was explained as an initial burst or exponential phase during the first 24 h, followed by a declining phase and a third and final low constant elution phase.…”

Section: Discussionmentioning

confidence: 99%

Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature

James

Larson

2015

Renal Failure

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High-dose antibiotic-loaded bone cement (ALBC) spacers are commonly used to treat prosthetic joint infections following total hip and knee arthroplasties. This methodology can provide high local antibiotic concentrations while minimizing systemic exposure and toxicity. The occurrence of acute kidney injury (AKI) is rarely reported. Available literature suggests that the rate may be higher than previously thought. We report a case of significant systemic tobramycin absorption with concomitant acute renal failure in a 69-year-old female following the implantation of a high-dose ALBC spacer containing both tobramycin and vancomycin. The tobramycin level 24 h post-surgery was 5.8 mcg/mL. Due to concomitant renal failure, antibiotic clearance was poor and resulted in prolonged exposure to elevated aminoglycoside levels. Recovery of renal function occurred, but clinicians should be vigilant in considering the potential impact ALBC spacers can have on post-operative renal function if antibiotic elution is higher than expected.

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Synthesis of soluble and thermally stable polyamides from diamine containing (quinolin‐8‐yloxy) aniline pendant group

Ghaemy

Bazzar

2009

J of Applied Polymer Sci

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A novel diamine monomer having pendant 4-(quinolin-8-yloxy) aniline group was successfully synthesized via aromatic substitution reaction of 8-quinolinol with p-fluoronitrobenzene followed by Pd/C catalyzed hydrazine reduction, amidation reaction between 4-(quinolin-8-yloxy) aniline and 3,5-dinitrobenzoylcholoride followed by Pd/C catalyzed hydrazine reduction. The diamine monomer was fully characterized by using FTIR,

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The effect of mixing on gentamicin release from polymethylmethacrylate bone cements

Cited by 97 publications

References 16 publications

Hand-mixed and Premixed Antibiotic-loaded Bone Cement Have Similar Homogeneity

Hand-mixed and Premixed Antibiotic-loaded Bone Cement Have Similar Homogeneity

Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature

Synthesis of soluble and thermally stable polyamides from diamine containing (quinolin‐8‐yloxy) aniline pendant group

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