The Effect of Microneedling with a Roller Device on the Viability of Random Skin Flaps in Rats

Abstract

The authors' study showed that the microneedling method applied directly on the flap could be a faster, safer, and more effective therapy modality to increase flap viability.

The efficacy and safety of combined microneedle fractional radiofrequency and sublative fractional radiofrequency for acne scars in Asian skin

“…It is clear that fractionating RF energy over microneedles allows discrete areas of electrothermal damage to be delivered directly to the dermis, and when the needle shafts are insulated leaving only the tips as the live electrodes, the RF‐induced damage is clearly limited to the dermis, with the epidermis undergoing purely mechanical needling. Needling alone has been proved beneficial to the skin, improving blood flow in an animal flap model and enhancing wound healing compared with untreated controls . The concept of delivering damage selectively to the dermis underneath the unharmed epidermis using non‐ablative laser was introduced in the early 2000s as an answer to prolonged downtime and severe side effects following full face ablative laser resurfacing, but patient satisfaction was low even though the dermal histology showed significant improvement .…”

The outcomes of dexmedetomidine and calcitriol on flap viability

“…The pedicle of the flap restores its functions almost entirely; however, the challenging issue is the distal zone necrosis due to the insufficient blood flow and related IR injury. Therefore, to overcome IR injury with the least damage, several agents have been tried to increase the blood flow and reduce IR injury effects to random pattern skin flaps 25 - 27 .…”

A Biomimetic 3D‐Self‐Forming Approach for Microvascular Scaffolds

“…[ 19 ] In addition, hollow structures are not completely remodeled with these methods, and the complicated fabricating procedures are extremely difficult to control. For example, the simulation and remodeling of haversian canal in bones (φ = 60–90 µm), [ 20 ] microvessels in flaps (φ = 20–500 µm), [ 21–23 ] and retinal vessels (φ = 20–200 µm) [ 24,25 ] are still very difficult to be realized. Therefore, exploration on the early stage of microvessel regeneration is crucial and difficult.…”