The effect of microchannel width on mixing efficiency of microfluidic electroosmotic mixer

Forouzanfar, Shahrzad; Talebzadeh, Nima; Zargari, Siavash; Veladi, Hadi

doi:10.1109/icrom.2015.7367856

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…As is shown in No.1 diagram, red line represents Zeta potential value is positive, Blue line represents Zeta potential value is negative. Different Zeta potential distribution can be realized by different settings of coating material in the wall [10].…”

Section: Channel Structure and Wall Zeta Potential Designmentioning

confidence: 99%

Simulation study on a DC-drive Electroosmotic Micromixer

Meng¹,

Li²,

Tang³

et al. 2017

Proceedings of the 2nd International Conference on Computer Engineering, Information Science &Amp; Application Technology (ICCI

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Abstract. In this paper, a type of DC-drive electroosmotic micro-mixer is proposed by numerical simulation. The model was built and optimized with multi-field coupling technique in finite element formation, in which the mixing efficiency was controlled by changing the Zeta potential distribution of the wall to make it under different driving voltage. In conclusion: (1) Significantly different characters can be observed by different zeta distribution settings; (2) Intensity of mixing can be improved by forming vortex with adequate size in the interface where the solute diffuse; (3) Compared with alternating current, the mixture in channel forced by direct current can get a more stable mixing performance.

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Section: Channel Structure and Wall Zeta Potential Designmentioning

confidence: 99%

Simulation study on a DC-drive Electroosmotic Micromixer

Meng¹,

Li²,

Tang³

et al. 2017

Proceedings of the 2nd International Conference on Computer Engineering, Information Science &Amp; Application Technology (ICCI

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“…In the LIGA process, precision electroforming of the metal mold is a key step that influences the quality of the molded polymer products [9,10]. The functions of microfluidic chips are largely determined by the size of the microfeatures [11][12][13]. For micro features with large width or high aspect ratio, the electroformed microcolumns are easily confronted with the problem of low filling ratio or void defect [14].…”

Section: Introductionmentioning

confidence: 99%

Mass transfer characteristics at cathode/electrolyte interface during electrodeposition of nickel microcolumns with various aspect ratios

Dong,

Jiang,

Drummer

et al. 2023

J. Micromech. Microeng.

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The filling behaviour of electrodeposited microcolumns is strongly influenced by the mass transfer characteristics at the cathode/electrolyte interface. This study aims to elucidate the influence of the mass transfer characteristics (ion supplementation via diffusion and ion consumption via deposition) on the electrodeposition of microcolumns, thus providing feasible solutions for improving void defects with different feature sizes. The results indicate that ion consumption plays an important role in the mass transfer within large-width microcavities (100 μm). For large-width microcolumns, longer electroforming times lead to higher ion consumption, resulting in nonuniform ion concentration distribution, and consequently uneven deposition rates along the microcavity wall. In microcavities with high aspect ratio (5:1), ion supplementation plays a major role. The low ion supplementation rate does not support a uniform deposition, resulting in a large void defect and a low filling ratio in the deposited microcolumns. Therefore, reducing the ion consumption rate by decreasing the current density from 1 A/dm2 to 0.25 A/dm2 can effectively increase the filling ratio in large-width microcolumns with no significant effect on high aspect ratio microcolumns. On the contrary, the pulse reverse current (forward pulse current density 1 A/dm2, reverse pulse current density 2 A/dm2, frequency 1 Hz, forward pulse duty cycle 0.9) can increase the filling ratio in the high aspect ratio microcolumns by accelerating ion supplementation through dissolution of the deposited layer. By further increasing the reverse pulse current density from 2 A/dm2 to 6 A/dm2, void defects can be completely eliminated and even void-free deposition of high aspect ratio microcolumns (5:1) can be achieved.

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“…For instance, deploying novel synthesis techniques such as bipolar exfoliation can reduce the cost of fabrication [15][16][17][18]. Moreover, label-free electrochemical detection can reduce the cost of operation and blood sample consumption by requiring relatively simple sample preparation [19][20][21][22]; although, the performance of the proposed label-free electrochemical aptasensors (e.g., dynamic range, selectivity, and sensitivity) lags the performance of other sensing techniques such as optical and labeled aptasensors, which indicates the necessity of additional improvements.…”

Section: Introductionmentioning

confidence: 99%

In-Situ Integration of 3D C-MEMS Microelectrodes with Bipolar Exfoliated Graphene for Label-Free Electrochemical Cancer Biomarkers Aptasensor

2022

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The electrochemical label-free aptamer-based biosensors (also known as aptasensors) are highly suitable for point-of-care applications. The well-established C-MEMS (carbon microelectromechanical systems) platforms have distinguishing features which are highly suitable for biosensing applications such as low background noise, high capacitance, high stability when exposed to different physical/chemical treatments, biocompatibility, and good electrical conductivity. This study investigates the integration of bipolar exfoliated (BPE) reduced graphene oxide (rGO) with 3D C-MEMS microelectrodes for developing PDGF-BB (platelet-derived growth factor-BB) label-free aptasensors. A simple setup has been used for exfoliation, reduction, and deposition of rGO on the 3D C-MEMS microelectrodes based on the principle of bipolar electrochemistry of graphite in deionized water. The electrochemical bipolar exfoliation of rGO resolves the drawbacks of commonly applied methods for synthesis and deposition of rGO, such as requiring complicated and costly processes, excessive use of harsh chemicals, and complex subsequent deposition procedures. The PDGF-BB affinity aptamers were covalently immobilized by binding amino-tag terminated aptamers and rGO surfaces. The turn-off sensing strategy was implemented by measuring the areal capacitance from CV plots. The aptasensor showed a wide linear range of 1 pM–10 nM, high sensitivity of 3.09 mF cm−2 Logc−1 (unit of c, pM), and a low detection limit of 0.75 pM. This study demonstrated the successful and novel in-situ deposition of BPE-rGO on 3D C-MEMS microelectrodes. Considering the BPE technique’s simplicity and efficiency, along with the high potential of C-MEMS technology, this novel procedure is highly promising for developing high-performance graphene-based viable lab-on-chip and point-of-care cancer diagnosis technologies.

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The effect of microchannel width on mixing efficiency of microfluidic electroosmotic mixer

Cited by 6 publications

References 11 publications

Simulation study on a DC-drive Electroosmotic Micromixer

Simulation study on a DC-drive Electroosmotic Micromixer

Mass transfer characteristics at cathode/electrolyte interface during electrodeposition of nickel microcolumns with various aspect ratios

In-Situ Integration of 3D C-MEMS Microelectrodes with Bipolar Exfoliated Graphene for Label-Free Electrochemical Cancer Biomarkers Aptasensor

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