The effect of material characteristics, of surface topography and of implant components and connections on soft tissue integration: a literature review

Rompen, Eric; Domken, Olivier; Degidi, Marco; Pontes, Ana Emília Farias; Piattelli, Adriano

doi:10.1111/j.1600-0501.2006.01367.x

Cited by 276 publications

(287 citation statements)

References 126 publications

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“…It has been reported that peri-implant connective tissue attachments consisting of fibroblasts and collagen are similar to scar tissue, and have less cells than healthy periodontium [10]. These reports suggest that the enhancement of periimplant soft tissue adhesion is an important stage in promoting implant acceptance into the oral cavity.…”

Section: Introductionmentioning

confidence: 71%

Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts

et al. 2012

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In the present study, we investigated the hydrothermal treatment of titanium with divalent cation solutions and its effect in promoting the adhesion of gingival epithelial cells and fibroblasts in vitro. Gingival keratinocyte-like Sa3 cells or fibroblastic NIH3T3 cells were cultured for 1 h on experimental titanium plates hydrothermally-treated with CaCl2 (Ca) or MgCl2 (Mg) solution, or distilled water (DW). The number and adhesive strengths of attached cells on the substrata were then analyzed. The number of Sa3 cells adhering to the Ca- and Mg-treated plates was significantly larger than in the DW group, but the strength of this adhesion did not differ significantly between groups. In contrast, NIH3T3 cell adhesion number and strength were increased in both the Ca and Mg groups compared to the DW group. Fluorescent microscopic observation indicated that, in all groups, Sa3 had identical expression levels of integrin β4 and development of actin filaments, whereas NIH3T3 cells in the Ca and Mg groups displayed much stronger punctate cytoplasmic signals for vinculin and more bundle-shaped actin filaments than cells in the DW group. As a result, it was indicated that the hydrothermal treatment of titanium with Ca or Mg solution improved the integration of soft tissue cells with the substrata, which may facilitate the development of a soft tissue barrier around the implant.

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Section: Introductionmentioning

confidence: 71%

Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts

et al. 2012

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“…The biological width around natural teeth has been reported to be about 2 mm, composed of 1 mm of epithelial attachment mediated by the JE and 1 mm of gingival connective tissue attachment (Gargiulo et al, 1961;Vacek et al, 1994). Many studies have reported that the peri-implant JE is about 2 mm long (Myshin and Wiens, 2005;Rompen et al, 2006;references above). Thus, the increase in the dimension of the dento-gingival complex around oral implants is largely due to the increase in the length of the peri-implant JE, suggesting that conventional implant surfaces cannot deter the formation of "long epithelial attachment" (Fig.…”

Section: Adhesion Of Peri-implant Epitheliummentioning

confidence: 99%

Epithelial Integrins with Special Reference to Oral Epithelia

et al. 2011

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A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/supplemental. AbstrAct Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or implant surface to maintain health. After injury or wounding, epithelial tissue rapidly migrates to form the initial epithelial cover to restore the barrier against infection. These events are crucially dependent on deposition of extracellular matrix and proper activation and function of integrin receptors in the epithelial cells. Recent experimental evidence suggests that epithelial integrins also participate in the regulation of periodontal inflammation. In this review, we will discuss the structure and function of epithelial integrins and their extracellular ligands and elaborate on their potential role in disease and repair processes in the oral cavity.

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“…Various approaches have been used to enhance osseointegration, such as control of surface topography with sandblasting, acid-etching, and hydroxyapatite coating (3)(4)(5). Rapid and secure osseointegration improves long-term outcomes (6,7), but several in vitro and animal studies have shown that adhesion of soft tissue to the dental abutment surface is required for long-term success, as it establishes an effective biological seal between soft tissue and the implant surface, thus limiting bacterial penetration, gingival recession, and bone recession (8).…”

Section: Introductionmentioning

confidence: 99%

Effects of cleaning methods for custom abutment surfaces on gene expression of human gingival fibroblasts

et al. 2017

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The aim of this study was to develop an effective method for cleaning implant abutments made by computer-aided design and computer-aided manufacturing techniques and to investigate the effect of decontamination in vitro. Briefly, a newly developed reagent (PK) and/or vacuum plasma (Plasma) were used to clean the surfaces of zirconia disks, and the effects of this decontamination were evaluated by X-ray photoelectron spectroscopy. Human gingival fibroblasts (HGFs) were cultured on sample disks for 6, 24, and 48 h. We evaluated cell attachment and gene expression of the acute inflammatory cytokines interleukin-6 and vascular endothelial growth factor A, and type 1 collagen. In the PK and PK+Plasma groups, surface contaminants were reduced by washing. In addition, HGF attachments was increased in the PK and PK+Plasma groups. Gene expressions of interleukin-6 and vascular endothelial growth factor A were lower at 6 h. Gene expression of type 1 collagen was increased at all time points after seeding. These results suggest that decontamination of implant abutment surfaces is important in initial HGF attachment and may improve the biological seal of peri-implant soft tissue.

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The effect of material characteristics, of surface topography and of implant components and connections on soft tissue integration: a literature review

Cited by 276 publications

References 126 publications

Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts

Effect of Titanium Surface Calcium and Magnesium on Adhesive Activity of Epithelial-Like Cells and Fibroblasts

Epithelial Integrins with Special Reference to Oral Epithelia

Effects of cleaning methods for custom abutment surfaces on gene expression of human gingival fibroblasts

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