The Effect of Massive Small Bowel Resection and Oral Epidermal Growth Factor Therapy on SGLT-1 Distribution in Rabbit Distal Remnant

Chung, Bonghoon; Wallace, Laurie E.; Winkfein, Robert K; O’Loughlin, Edward; Hardin, James A.; Gall, David

doi:10.1203/01.pdr.0000098500.94041.9b

Cited by 5 publications

(2 citation statements)

References 36 publications

(51 reference statements)

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“…EGF is capable of redistributing the preformed microvillus plasma membrane to significantly increase brush border surface area 45). In addition to its mitogenic effects, absorption of various nutrients has been shown to be augmented by EGF (46‐50).…”

Section: Introductionmentioning

confidence: 99%

Critical Roles for EGF Receptor Signaling During Resection‐Induced Intestinal Adaptation

Warner

Erwin

2006

J. pediatr. gastroenterol. nutr.

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The adaptation response of the remnant gut to massive intestinal resection represents a mitogenic signal involving all bowel wall layers. In the mucosa, this response results in taller villi, deeper crypts, and enhanced enterocyte turnover as gauged by greater rates of both proliferation and apoptosis. Although the exact mechanisms and mediators of this important compensatory response remain incompletely understood, work from this laboratory over the past decade has illuminated a crucial role for intact receptor signaling for a robust response. Using a murine model for intestinal resection, transgenic, null and mutant mouse strains have provided unique experimental paradigms to dissect molecular mechanisms for epidermal growth factor (EGF) receptor-directed influence on adaptation. Stimulation of this receptor is linked with a magnified adaptation response, whereas attenuation of the activity of this receptor is associated with impaired adaptation. EGF receptor activation and expression are both elevated in enterocytes after resection, and salivary levels of EGF-the major ligand for the EGF receptor-are increased. In addition to stimulation of enterocyte proliferation, EGF receptor signaling prevents the typical increase in rates of enterocyte apoptosis, probably by affecting the ratio of expression of both pro- and anti-apoptotic Bcl-2 family members. The key to optimizing care for patients with short gut syndrome will necessarily follow a thorough understanding of intestinal adaptation responses.

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Section: Introductionmentioning

confidence: 99%

Critical Roles for EGF Receptor Signaling During Resection‐Induced Intestinal Adaptation

Warner

Erwin

2006

J. pediatr. gastroenterol. nutr.

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“…The ultimate goal of these efforts is to wean these patients off PN and restore adequate intestinal function 3 . Current measures for intestinal adaptation and rehabilitation often focus on barrier function, net nutrient uptake capacity, nutrient transporter expression, morphological adaptations and even plasma markers of enterocyte activity 16 , 52 – 58 . Unfortunately, these markers cannot always predict outcome and efforts continue to define and fine‐tune adaptive responses and identify potential trophic factors that might stimulate these responses.…”

Section: Discussionmentioning

confidence: 99%

Complex Dietary Protein Improves Growth Through a Complex Mechanism of Intestinal Peptide Absorption and Protein Digestion

Hansen

Ashley

Chung

2013

J Parenter Enteral Nutr

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A complex protein diet stimulates in an altered pattern of intestinal peptide transporter expression and intestinal proteolytic activity that results in improved growth compared with a diet of elemental amino acids. This improved growth appears to be the result of increased efficiency of a smaller number of enterocytes. These data might be useful in targeting intestinal rehabilitation therapies for short bowel syndrome and other risk factors for intestinal failure.

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Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon

Sakai

Sagara

Matsumoto

et al. 2014

Pharmacological Research

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The Effect of Massive Small Bowel Resection and Oral Epidermal Growth Factor Therapy on SGLT-1 Distribution in Rabbit Distal Remnant

Cited by 5 publications

References 36 publications

Critical Roles for EGF Receptor Signaling During Resection‐Induced Intestinal Adaptation

Critical Roles for EGF Receptor Signaling During Resection‐Induced Intestinal Adaptation

Complex Dietary Protein Improves Growth Through a Complex Mechanism of Intestinal Peptide Absorption and Protein Digestion

Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon

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