The Effect Of Macrolides On Myofibroblast Differentiation And Collagen Production In Nasal Polyp-Derived Fibroblasts

Park, Hyo-Hyun; Cho, Jung-Sun; Park, Il Ho; Kim, Yong‐Dae; Lee, Heung Man

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4213

Cited by 15 publications

(18 citation statements)

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“…19 More interestingly, Park et al recently reported that macrolides effectively inhibited myofibroblast differentiation and collagen production in nasal polyp-derived fibroblasts. 20 In this study, we demonstrated for the first time that high-dose clarithromycin treatment (over two to four weeks) significantly inhibited both IL-8 and IL-5 concentrations in nasal secretions; this reduction in IL-5 levels was not found for the low-dose group. Highdose clarithromycin treatment was also associated with better clinical efficacy than the low-dose treatment.…”

Section: Discussionmentioning

confidence: 62%

High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis

Fan

Hong

et al. 2014

J. Laryngol. Otol.

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Section: Discussionmentioning

confidence: 62%

High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis

Fan

Hong

et al. 2014

J. Laryngol. Otol.

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“…In addition to modulating NF-kB proinflammatory cytokine production, [744][745][746][747][748] studies suggest a non-allergy-mediated role for macrolides in reducing nasal fibroblast proliferation, differentiation, collagen production, and decreased eosinophilic infiltration into nasal epithelium and lamina propria. [1030][1031][1032] An EBRR by Soler et al 752 addressed the utility of macrolide use in CRS. Neither of the 2 RCTs exclusively evaluated CRSwNP patients and just 3 of the remaining 15 retrospective studies specifically assessed CRSwNP patients.…”

Section: Viiie3 Crswnp Management: Oral Corticosteroidsmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…TGF‐β1 can enhance ECM production and myofibroblast differentiation in pulmonary fibroblasts from individuals with COPD . TGF‐β1 can also induce myofibroblast differentiation and collagen production in nasal polyp–derived fibroblasts (NPDFs), which can be inhibited by simvastatin and macrolides . However, partly due to the heterogeneity between nasal and lung fibroblasts that have heterogeneous responsiveness to TGF‐β1, the pathological outcomes of inflammation in the upper and lower airways are different .…”

Section: The Tgf‐β Activation and Signaling Pathwaymentioning

confidence: 99%

Transforming growth factor‐beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling

Yang

Zhang

Crombruggen

et al. 2012

Allergy

159

139

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Airway diseases such as chronic rhinosinusitis, asthma, and chronic obstructive pulmonary disorder are characterized by inflammation and remodeling. Among inflammatory and extracellular matrix regulatory cytokines, transforming growth factor-beta (TGF-b) stands central, as it possesses both important immunomodulatory and fibrogenic activities, and should be considered a key for understanding inflammation and remodeling processes. This review will briefly summarize the recent findings on the role of TGF-b1, from the view points of inflammation and remodeling, and discuss the role of TGF-b in the upper and lower airway diseases. This may reveal new perspectives in the understanding of airway inflammation and remodeling processes and may open innovative treatment strategies for the regulation of TGF-b1.

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The Effect Of Macrolides On Myofibroblast Differentiation And Collagen Production In Nasal Polyp-Derived Fibroblasts

Cited by 15 publications

References 0 publications

High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis

High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Transforming growth factor‐beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling

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