Transforming growth factor‐beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling

Yang, Yucheng; Zhang, N.; Crombruggen, Koen Van; Hu, Geng; Hong, Suling; Bachert, Claus

doi:10.1111/j.1398-9995.2012.02880.x

Cited by 159 publications

(145 citation statements)

References 104 publications

(126 reference statements)

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“…TGF-β1 has also been implicated in the pathogenesis of various types of cancer, including lung cancer [42,43]. In addition, TGF-β1, via pro-fibrotic activity, may also contribute to the development of chronic obstructive pulmonary disease (COPD) [44]. It is noteworthy that, even in the setting of HAART-mediated viral suppression, circulating levels of TGF-β1 remain elevated, consistent with ongoing chronic immune activation [41].…”

Section: Cd4mentioning

confidence: 86%

Impact of HIV infection and smoking on lung immunity and related disorders

2015

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HIV-infected persons not only have higher rates of smoking than the general population, but are also unusually vulnerable to the associated adverse health effects, both infective and noninfective in origin. Indeed, in the setting of well-organised care and availability of highly active antiretroviral therapy, HIV-infected smokers lose more life-years to smoking than to HIV infection per se, presenting a major challenge to healthcare providers. Not surprisingly, the respiratory system is particularly susceptible to the damaging interactive chronic inflammatory and immunosuppressive effects of HIV and smoking, intensifying the risk of the development of opportunistic infections, as well as lung cancer and obstructive lung disorders. The impact of smoking on the immunopathogenesis and frequencies of these respiratory conditions in the setting of HIV infection, as well as on the efficacy of antiretroviral therapy, represent the primary focus of this review. @ERSpublications Smoking exacerbates the immunosuppressive/pro-inflammatory effects of HIV, increasing the risk of pulmonary disease

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Section: Cd4mentioning

confidence: 86%

Impact of HIV infection and smoking on lung immunity and related disorders

2015

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“…MMP-9 activates signaling pathway of TGF-β 1 , which contributes to increased fibrosis of the airways. 22 Tissue metalloproteinase inhibitors prevent destructive activity of MMPs. Gelatinase B (MMP-9) is responsible for degradation of collagen IV, a major component of the basement membrane, and elastin fibers.…”

Section: Immune Mediators In Bronchoalveolar Lavage Fluidmentioning

confidence: 99%

Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease

Górka¹,

Soja²,

Jakieła³

et al. 2016

Polish Archives of Internal Medicine

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KEY WORDSchronic obstructive pulmonary disease, computed tomography, emphysema score, endobronchial ultrasound, markers of remodelling ABSTRACT INTRODUCTION Airway remodeling plays an important role in the development of chronic obstructive pulmonary disease (COPD). Imaging methods, such as computed tomography (CT) and endobronchial ultrasound (EBUS), may be useful in the assessment of structural alterations in the lungs.OBJECTIVES The aim of this study was to evaluate a relationship between the severity of emphysema assessed by chest CT, the thickness of bronchial wall layers measured by EBUS, and the markers of remodeling in bronchoalveolar lavage fluid (BALF) in patients with COPD. PATIENTS AND METHODSThe study included 33 patients with COPD who underwent pulmonary function tests, emphysema score assessment by chest CT, as well as bronchofiberoscopy with EBUS in order to measure the total bronchial wall thickness and, separately, layers L 1 , L 2 , and L 3-5 . Selected remodeling (matrix metalloproteinase 9 [MMP-9], tissue inhibitor of metalloproteinase 1, transforming growth factor β 1 [TGF-β 1 ]) and inflammatory markers (neutrophil elastase, eosinophil cationic protein) were measured in BALF samples using an enzyme-linked immunosorbent assay.RESULTS MMP-9 levels in BALF were significantly higher in patients with very severe bronchial obstruction than in those with moderate and mild bronchial obstruction (P = 0.02), and showed a negative correlation with forced expiratory volume in 1 second (r = -0.538, P = 0.002). The thickness of L 1 and L 2 , which histologically correspond to the mucosa, submucosa, and smooth muscle, demonstrated a positive correlation with TGF-β 1 levels in BALF (r = 0.366, P = 0.046 and r = 0.425, P = 0.02) and the thickness of L 1 showed a negative association with neutrophil elastase levels (r = -0.508, P = 0.004). There was no significant correlation between the analyzed markers in BALF and the emphysema score. CONCLUSIONS Significant correlations of TGF-β 1 and elastase with the thickness of bronchial wall layers, and of MMP-9 with the severity of obstruction, may suggest the involvement of these markers in airway remodeling in patients with COPD.

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“…Since TGFB1 is associated with fibrosis and accumulation of the extracellular matrix after lung injury or inflammation, it has an essential role in airway remodeling in asthma [21]. It is postulated that variants in the TGFB1 gene could increase the profibrotic and anti-inflammatory effects of TGFB1.…”

Section: Discussionmentioning

confidence: 99%