2016
DOI: 10.1113/jp272030
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The effect of lung deformation on the spatial distribution of pulmonary blood flow

Abstract: Tidal volume lung inflation results in structural changes in the pulmonary circulation, potentially affecting pulmonary perfusion. We hypothesized that perfusion is recruited to regions receiving the greatest deformation from a tidal breath, thus ensuring ventilation-perfusion matching. Density-normalized perfusion (DNP) magnetic resonance imaging data were obtained in healthy subjects (n = 7) in the right lung at functional residual capacity (FRC), FRC+500 ml, and FRC+1.0 l. Using deformable image registratio… Show more

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Cited by 6 publications
(7 citation statements)
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“…For healthy volunteers, the respiratory index α global (which is a measure of the change in lung perfusion during the breathing cycle; see “Theory” section) was, on average, 1.02 ± 0.07, in accordance with literature results (data elaborated from , α global = 1.04). Interestingly, α global appears to be different for male and female (on average 1.07 and 0.95, respectively), but a larger collective of volunteers would be required for conclusive results.…”
Section: Discussionsupporting
confidence: 87%
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“…For healthy volunteers, the respiratory index α global (which is a measure of the change in lung perfusion during the breathing cycle; see “Theory” section) was, on average, 1.02 ± 0.07, in accordance with literature results (data elaborated from , α global = 1.04). Interestingly, α global appears to be different for male and female (on average 1.07 and 0.95, respectively), but a larger collective of volunteers would be required for conclusive results.…”
Section: Discussionsupporting
confidence: 87%
“…The premise of Equation [] has already been assumed by other ventilation‐weighted imaging techniques and is corroborated by recent findings that show a non‐statistically significant pulmonary perfusion change over the whole lung and no significant lobar perfusion redistribution for breath‐holds in the tidal volume region. As a result, the respiratory index αlocal(truex) reflects virtually lung ventilation and is independent of the lung density (see Eq.…”
Section: Theorysupporting
confidence: 67%
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“…Assuming that the distortion presented in the field would manifest itself as a continuous function without any local rapid changes in such small volume [ 30 32 ], a global transformation could properly describe the field distortion and generate the correction factors for scanning protocols. Affine transformation with 3D cubic b-spline interpolation was implemented in the study [ 33 ].…”
Section: Methodsmentioning
confidence: 99%