Rapid 3D in vivo 1H human lung respiratory imaging at 1.5 T using ultra‐fast balanced steady‐state free precession

Pusterla, Orso; Bauman, Grzegorz; Wielpütz, Mark O.; Nyilas, Sylvia; Latzin, Philipp; Bieri, Oliver

doi:10.1002/mrm.26503

Cited by 19 publications

(26 citation statements)

References 48 publications

(63 reference statements)

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“…Although the sponge model requires breath-holding at several inspiratory levels, these maneuvers are well tolerated and performed by patients (16). As a result, OE MRI with the sponge model should also be feasible in the clinical setting and specific to O 2 -related signal changes in impaired lung regions (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Pusterla

Bauman

Bieri

2017

Magnetic Resonance in Med

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Purpose: To assess the feasibility of 3D oxygen-enhanced (OE) MRI of the lung at 1.5T using multi-volumetric ultra-fast balanced steady-state free precession (ufSSFP) acquisitions. Methods: Isotropic imaging of the lung for OE-MRI was performed with an adapted 3D ufSSFP sequence using five breathhold acquisitions ranging from functional residual capacity to tidal inspiration under both normoxic (room air) and hyperoxic (100% O 2 ) gas conditions. For each O 2 concentration, a sponge model (which captures the parenchymal signal intensity variation as a function of the lung volume) was fitted to the acquired multivolumetric datasets after semiautomatic lung segmentation and deformable image registration. From the retrieved model parameters, 3D oxygen-enhancement maps were calculated. Results: For OE ufSSFP imaging, the maximum parenchymal signal is observed for flip angles around 23 under both normoxic and hyperoxic conditions. It is found that the sponge model accurately describes parenchymal signal at different breathing positions, thereby mitigating the confounding bias in the estimated oxygen enhancement from residual density modulations. From the model, an average lung oxygen enhancement of 7.0% 6 0.3% was found in the healthy volunteers, and the oxygenenhancement maps indicate a ventral to dorsal gravitation-related gradient. Conclusion:The study demonstrates the feasibility of wholelung OE-MRI from multi-volumetric ufSSFP in healthy volunteers.

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Section: Discussionmentioning

confidence: 99%

“…Based on multi-volumetric ufSSFP lung scans (acquired at different inspiratory phases), we propose a new framework for robust volumetric OE-MRI that accounts for signal intensity variations of the lung parenchyma using an adapted sponge model (16).…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Pusterla

Bauman

Bieri

2017

Magnetic Resonance in Med

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“…Image postprocessing was identical for ufSSFP and VIBE, and essentially similar to previous works . Signal preservation by image registration was analyzed by comparing the whole‐lung signal before and after image registration.…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, balanced steady‐state free precession (bSSFP) offers the highest SNR per unit of time among all MRI sequences . Banding artifacts that typically compromise the image quality of bSSFP in the chest have been recently mitigated by the development of an ultra‐fast SSFP imaging approach (ufSSFP); a variant of bSSFP with ultrashort repetition times, which has already demonstrated potential for morphological and functional assessment of the lungs . Due to their mixed contrast behavior driven by the T 2 /T 1 relaxation time ratio, bSSFP sequences are frequently regarded as being rather insensitive to gadolinium‐based contrast agents, although their potential use after contrast administration has been demonstrated and advised .…”

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confidence: 99%

“…16 Banding artifacts that typically compromise the image quality of bSSFP in the chest have been recently mitigated by the development of an ultra-fast SSFP imaging approach (ufSSFP) 17 ; a variant of bSSFP with ultrashort repetition times, which has already demonstrated potential for morphological and functional assessment of the lungs. 8,[18][19][20] Due to their mixed contrast behavior driven by the T 2 /T 1 relaxation time ratio, 21 bSSFP sequences are frequently regarded as being rather insensitive to gadolinium-based contrast agents, although their potential use after contrast administration has been demonstrated and advised. 22,23 From the theory, 16 the signal enhancement for SSFP after contrast administration is expected to be higher for tissue with long T 1 and short T 2 , such as the lung (T 1 /T 2 1375/66 [ms/ms] at 1.5T), 24 as compared to the blood (T 1 /T 2 1300/300) and fluids with comparable T 1 /T 2 .…”

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confidence: 99%

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Signal enhancement ratio imaging of the lung parenchyma with ultra‐fast steady‐state free precession MRI at 1.5T

Pusterla

Sommer

Santini

et al. 2018

Magnetic Resonance Imaging

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Proton MRI of the Lung: How to Tame Scarce Protons and Fast Signal Decay

Voskrebenzev

2020

Magnetic Resonance Imaging

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Pulmonary proton MRI techniques offer the unique possibility of assessing lung function and structure without the requirement for hyperpolarization or dedicated hardware, which is mandatory for multinuclear acquisition. Five popular approaches are presented and discussed in this review: 1) oxygen enhanced (OE)‐MRI; 2) arterial spin labeling (ASL); 3) Fourier decomposition (FD) MRI and other related methods including self‐gated noncontrast‐enhanced functional lung (SENCEFUL) MR and phase‐resolved functional lung (PREFUL) imaging; 4) dynamic contrast‐enhanced (DCE) MRI; and 5) ultrashort TE (UTE) MRI. While DCE MRI is the most established and well‐studied perfusion measurement, FD MRI offers a free‐breathing test without any contrast agent and is predestined for application in patients with renal failure or with low compliance. Additionally, FD MRI and related methods like PREFUL and SENCEFUL can act as an ionizing radiation‐free V/Q scan, since ventilation and perfusion information is acquired simultaneously during one scan. For OE‐MRI, different concentrations of oxygen are applied via a facemask to assess the regional change in T1, which is caused by the paramagnetic property of oxygen. Since this change is governed by a combination of ventilation, diffusion, and perfusion, a compound functional measurement can be achieved with OE‐MRI. The known problem of fast T2* decay of the lung parenchyma leading to a low signal‐to‐noise ratio is bypassed by the UTE acquisition strategy. Computed tomography (CT)‐like images allow the assessment of lung structure with high spatial resolution without ionizing radiation. Despite these different branches of proton MRI, common trends are evident among pulmonary proton MRI: 1) free‐breathing acquisition with self‐gating; 2) application of UTE to preserve a stronger parenchymal signal; and 3) transition from 2D to 3D acquisition. On that note, there is a visible convergence of the different methods and it is not difficult to imagine that future methods will combine different aspects of the presented methods.

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Rapid 3D in vivo 1H human lung respiratory imaging at 1.5 T using ultra‐fast balanced steady‐state free precession

Abstract: Respiratory α-mapping derived from multivolumetric ufSSFP provides insights into functional lung impairment and may serve as a reproducible and normative measure for clinical studies. Magn Reson Med 78:1059-1069, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Cited by 19 publications

References 48 publications

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Three‐dimensional oxygen‐enhanced MRI of the human lung at 1.5T with ultra‐fast balanced steady‐state free precession

Signal enhancement ratio imaging of the lung parenchyma with ultra‐fast steady‐state free precession MRI at 1.5T

Proton MRI of the Lung: How to Tame Scarce Protons and Fast Signal Decay

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