The effect of LSD-25 on light-reinforced behaviour in the rat

Lowe, G.; Williams, D. I.

doi:10.1007/bf00422806

Cited by 8 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the 5-HT (and noradrenalin, NA) re-uptake inhibitor, imipramine, decreased the time spent in a novel Y-maze arm (Cox and Tye, 1975), but had no effect on preferences for a novel location in an exploration box (Hughes and Pither, 1987). Another 5-HT agonist, lysergic acid diethylamide-25, decreased bar-pressing for light onset (Lowe and Williams, 1972) and, with higher doses, the time spent in a novel chamber Geyer, 1982, 1985), but increased this latter measure with lower doses (Adams and Geyer, 1985), and had no effect on preferences for a novel location (Hughes, 1973). The involvement of 5-HT in neotic preferences of rats is complicated by a recent report of a negative relationship between levels of the transmitter in the brainstem and nose pokes in a hole board, but a positive relationship between the two in the amygdala (Ray et al, 2006).…”

Section: Effects Of Benzodiazepine Gabaergic and Serotonergic Drugsmentioning

confidence: 97%

Neotic preferences in laboratory rodents: Issues, assessment and substrates

Hughes

2007

Neuroscience & Biobehavioral Reviews

154

View full text Add to dashboard Cite

Section: Effects Of Benzodiazepine Gabaergic and Serotonergic Drugsmentioning

confidence: 97%

Neotic preferences in laboratory rodents: Issues, assessment and substrates

Hughes

2007

Neuroscience & Biobehavioral Reviews

154

View full text Add to dashboard Cite

“…Study of the reinforcing properties of a cue light. Because in the previous experiment the cue light facilitates acquisition of cocaine SA, we verified whether this stimulus could have positive reinforcing effects, as suggested by earlier studies (Lowe & Williams, 1969, 1972). For this purpose, eight naive rats were tested daily during 1 h for response to the contingent presentation of a 4‐s cue light.…”

mentioning

confidence: 99%

Influence of cue‐conditioning on acquisition, maintenance and relapse of cocaine intravenous self‐administration

Deroche-Gamonet¹,

Piat²,

Moal³

et al. 2002

Eur J of Neuroscience

View full text Add to dashboard Cite

Conditioning theories propose that, through a Pavlovian associative process, discrete stimuli acquire the ability to elicit neural states involved in the maintenance and relapse of a drug-taking behaviour. Experimental evidence indicates that drug-related cues play a role in relapse, however, their influence on the development and maintenance of drug self-administration has been poorly investigated. In this report, we analysed the effects of a drug-associated cue light on acquisition, maintenance and reinstatement of intravenous cocaine self-administration. The results show that a cocaine-associated cue light can act as an incentive in absence of the drug, but does not directly modify drug-reinforcing effects. Contingent and non-contingent presentations of a cocaine-associated cue light reinstated an extinguished self-administration behaviour. However, regardless of whether or not a cue light was associated with cocaine infusions, rats acquire cocaine intravenous self-administration reaching the same levels of intake. Furthermore, after self-administration has been acquired in presence of the cue light, the omission of the cue light or its non-contingent presentation did not modify rat behaviour. In conclusion, our work shows that cocaine-associated explicit cues do not directly interfere with the reinforcing effects of the drug.

show abstract

“…Interestingly, drugs that depress the response to light under experimental conditions, e.g. LSD-25 (27), may lead to photophilic preferences (such as 'feeling attracted to the sun like a magnet') or behaviour patterns (e.g. sun-gazing) in humans (28).…”

Section: Discussionmentioning

confidence: 99%

The assessment of light intensity preference in psychiatric patients: a questionnaire

Gerbaldo

Cassady

Maurer

et al. 1997

Acta Psychiatr Scand

View full text Add to dashboard Cite

The assessment of abnormal light-related behaviour is important for methodological reasons, and has a prophylactic and heuristic value. Since no operationalization of these behaviour patterns has been published until now, we constructed a questionnaire to identify abnormal light intensity preference based on a systematic study and previous case reports. We administered the questionnaire to patients with schizophrenia (n = 46) or major depression (n = 55), and to healthy control subjects (n = 70). Photophilia was more frequently diagnosed in schizophrenia than in depression (P < 0.001). Photophobia was more frequently observed in depression than in schizophrenia; however, this difference was not statistically significant. None of the healthy subjects showed these phenomena. The kappa value was 0.66 for photophilia and 0.65 for photophobia. Patients with schizophrenia had a higher mean photophilia score than depressive patients (P < 0.001) and healthy subjects (P < 0.05). Depressed patients had higher photophobia scores than schizophrenics (P < 0.05) and healthy subjects (P < 0.001). The photophilia score was positively correlated and the photophobia score was negatively correlated with the light intensity preference (measured by means of a photometer) (P < 0.001). A significant positive correlation between the photophilia score and the percentage of time spent in bright and very bright areas was observed (P < 0.05). Scores were not related to age or gender. These results represent initial data in support of the validity and reliability of our questionnaire for distinguishing between patients with and without abnormal light-exposure behaviour patterns.

show abstract

The effect of LSD-25 on light-reinforced behaviour in the rat

Cited by 8 publications

References 16 publications

Neotic preferences in laboratory rodents: Issues, assessment and substrates

Neotic preferences in laboratory rodents: Issues, assessment and substrates

Influence of cue‐conditioning on acquisition, maintenance and relapse of cocaine intravenous self‐administration

The assessment of light intensity preference in psychiatric patients: a questionnaire

Contact Info

Product

Resources

About