Neotic preferences in laboratory rodents: Issues, assessment and substrates

Hughes, Robert N.

doi:10.1016/j.neubiorev.2006.11.004

Cited by 154 publications

(99 citation statements)

References 310 publications

(386 reference statements)

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“…This non-preference for novelty was in contrast to other paradigms using a preference for novelty to assess object recognition and episodic memory in mice and rats [17,22,32,70]. Neophobia for novel food, objects, or locations has been well-documented in rodents (see [23,31]), and can be altered by pharmacological challenge [6,26,76], rearing conditions [28], or genetic change [3,18,38,45,57,62]. Nonpreference for novelty has been shown to be strain-dependent in mice [26,34].…”

Section: Discussionmentioning

confidence: 99%

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

Moy

Nadler

Poe

et al. 2008

Behavioural Brain Research

178

182

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Repetitive behavior, a core symptom of autism, encompasses stereotyped responses, restricted interests, and resistance to change. These studies investigated whether different components of the repetitive behavior domain could be modeled in the exploratory hole-board task in mice. Four inbred mouse strains, C57BL/6J, BALB/cByJ, BTBR T + tf/J, and FVB/NJ, and mice with reduced expression of Grin1, leading to NMDA receptor hypofunction (NR1 neo/neo mice), were tested for exploration and preference for olfactory stimuli in an activity chamber with a 16-hole floor-board. Reduced exploration and high preference for holes located in the corners of the chamber were observed in BALB/cByJ and BTBR T+tf/J mice. All inbred strains had initial high preference for a familiar olfactory stimulus (clean cage bedding). BTBR T + tf/J was the only strain that did not demonstrate a shift in hole preference towards an appetitive olfactory stimulus (cereal or a chocolate chip), following home cage exposure to the food. The NR1 neo/neo mice showed lower hole selectivity and aberrant olfactory stimulus preference, in comparison to wildtype controls. The results indicate that NR1 neo/neo mice have repetitive nose poke responses that are less modified by environmental contingencies than responses in wildtype mice. 25-30% of NMDA-receptor hypomorphic mice also show self-injurious responses. Findings from the olfactory studies suggest that resistance to change and restricted interests might be modeled in mice by a failure to alter patterns of hole preference following familiarization with an appetitive stimulus, and by high preference persistently Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Discussionmentioning

confidence: 99%

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

Moy

Nadler

Poe

et al. 2008

Behavioural Brain Research

178

182

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“…show an instinctive attraction towards novelty, or neotic preference [5]. In general, animals are allowed to freely explore two identical sample objects during a sample-or learning trial.…”

Section: Introductionmentioning

confidence: 99%

Object recognition testing: Methodological considerations on exploration and discrimination measures

Akkerman

Blokland

Reneerkens

et al. 2012

Behavioural Brain Research

176

123

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“…The propensity to explore novel environments has been extensively studied in rodents (Hughes, 2007), but also in a variety of invertebrate species (e.g. Lindauer, 1952, bee;Wilson and Fowler, 1976, cockroach;Mather and Anderson, 1999, octopus;Mailleux et al, 2010, ant;Huber et al, 2011, crayfish).…”

Section: Introductionmentioning

confidence: 99%

“…Novelty is not an objective property of a stimulus but depends on the extent to which the stimulus was previously experienced (Hughes, 2007). There is evidence that the narrower the ecological niches exploited by animals, the more pronounced is their aversion to novelty.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity to tactile novelty in the terrestrial isopod, Porcellio scaber

Anselme

2013

Behavioural Processes

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Neotic preferences in laboratory rodents: Issues, assessment and substrates

Cited by 154 publications

References 310 publications

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

Object recognition testing: Methodological considerations on exploration and discrimination measures

Sensitivity to tactile novelty in the terrestrial isopod, Porcellio scaber

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