The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs

Wang, Shuhua; Ogawa, Takumi; Zheng, Shusen; Miyashita, Makiko; Tenkumo, Taichi; Gu, Zhenhua; Lian, Wenhai; Sasaki, Keiichi

doi:10.1016/j.jpor.2018.07.004

Cited by 6 publications

(13 citation statements)

References 25 publications

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“…Besides, no qualified article was found via manual search. Eventually, 15 manuscripts (Akca et al, 2007;Shi et al, 2010;Ogawa et al, 2011aOgawa et al, ,b, 2014Chen et al, 2012;Zhang et al, 2012b,c;Chatterjee et al, 2014;Liang et al, 2014;Zhou et al, 2015;Wang et al, 2016Wang et al, , 2018Ruppert et al, 2018Ruppert et al, , 2019Shibamoto et al, 2018) were recruited for qualitative analysis.…”

Section: Results Of the Searchmentioning

confidence: 99%

“…where g (m/s 2 ) represented the magnitude, A (m) was the amplitude, and f (Hz) was the frequency. Among studies involving non-OVX-DLV cases (Shi et al, 2010;Zhang et al, 2012a,b;Wang et al, 2018;Ruppert et al, 2019), the frequency, the magnitude and weekly loading time ranged 20-100 Hz (MD: 51.0 ± 41.0 Hz), 7.7-73.8 µm (MD: 19.3 ± 19.2 µm), and 50-210 min (MD: 92.0 ± 62.5 min), respectively. In fact, the results from Equation (1) concluded that the values of magnitude and frequency of DLV were significantly lower than those of WBV treatment.…”

Section: Outcomes Parametersmentioning

confidence: 99%

“…However, the therapeutic effect of DLV was not as good as that of WBV, and lower levels of DLV parameters indicated worse outcomes. Three studies (Shi et al, 2010;Zhang et al, 2012b;Wang et al, 2018) explored the optimal vibration parameters of DLV treatment, and the best parameters were as follows: 20 Hz frequency, 15 µm magnitude, and 210 min weekly loading time in rabbits; 40 Hz frequency, 7.8 µm magnitude and 50 min weekly loading time in rats; 40 Hz frequency, 8 µm magnitude and 50 min weekly loading time in rats. Discrepancies between different parameters may be attribute to different animal models, types of implants, and loading sites.…”

Section: Outcomes Parametersmentioning

confidence: 99%

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Does Low-Magnitude High-Frequency Vibration (LMHFV) Worth for Clinical Trial on Dental Implant? A Systematic Review and Meta-Analysis on Animal Studies

Bai

et al. 2021

Front. Bioeng. Biotechnol.

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Being as a non-pharmacological medical intervention, low-magnitude high-frequency vibration (LMHFV) has shown a positive effect on bone induction and remodeling for various muscle diseases in animal studies, among which dental implants osteointegration were reported to be improved as well. However, whether LMHFV can be clinically used in dental implant is still unknown. In this study, efficacy, parameters and side effects of LMHFV were analyzed via data before 15th July 2020, collecting from MEDLINE/PubMed, Embase, Ovid and Cochrane Library databases. In the screened 1,742 abstracts and 45 articles, 15 animal studies involving 972 implants were included. SYRCLE's tool was performed to assess the possible risk of bias for each study. The GRADE approach was applied to evaluate the quality of evidence. Random effects meta-analysis detected statistically significant in total BIC (P < 0.0001) and BV/TV (P = 0.001) upon loading LMHFV on implants. To conclude, LMHFV played an active role on BIC and BV/TV data according to the GRADE analysis results (medium and low quality of evidence). This might illustrate LMHFV to be a worthy way in improving osseointegration clinically, especially for osteoporosis.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO, identifier: NCT02612389

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Section: Results Of the Searchmentioning

confidence: 99%

Section: Outcomes Parametersmentioning

confidence: 99%

Section: Outcomes Parametersmentioning

confidence: 99%

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Does Low-Magnitude High-Frequency Vibration (LMHFV) Worth for Clinical Trial on Dental Implant? A Systematic Review and Meta-Analysis on Animal Studies

Bai

et al. 2021

Front. Bioeng. Biotechnol.

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“…After 6 months, 4 NGF-CS/HA-coating composite implants were implanted in the right mandibular premolar region, and 4 HA-coating implants were implanted in the left mandibular premolar. The observation time points were 2 weeks, 4 weeks, and 8 weeks as previous studies indicated [43,44], and there were 2 animals at each time point. The Beagle dogs were given intramuscular antibiotics to prevent infection 3 days after the operation.…”

Section: Establishment Of Experimental Animal Modelsmentioning

confidence: 99%

Nerve growth factor-chondroitin sulfate/hydroxyapatite-coating composite implant induces early osseointegration and nerve regeneration of peri-implant tissues in Beagle dogs

Huang

Gong

2021

J Orthop Surg Res

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Background Osseointegration is the premise of the chewing function of dental implant. Nerve growth factor (NGF), as a neurotrophic factor, can induce bone healing. However, the influence of NGF-chondroitin sulfate (CS)/hydroxyapatite (HA)-coating composite implant on the osseointegration and innervations is still not entirely clear. Materials and methods NGF-CS/HA-coating composite implants were prepared using the modified biomimetic method. The characteristics of NGF-CS/HA-coating implants were determined using a scanning electron microscope. After NGF-CS/HA-coating implants were placed in the mandible of Beagle dogs, the early osseointegration and innervation in peri-implant tissues were assessed through X-ray, Micro-CT, maximal pull-out force, double fluorescence staining, toluidine blue staining, DiI neural tracer, immunohistochemistry, and RT-qPCR assays. Results NGF-CS/HA-coating composite implants were made successfully, which presented porous mesh structures with the main components (Ti and HA). Besides, we revealed that implantation of NGF-CS/HA-coating implants significantly changed the morphology of bone tissues and elevated maximum output, MAR, BIC, and nerve fiber in the mandible of Beagle dogs. Moreover, we proved that the implantation of NGF-CS/HA-coating implants also markedly upregulated the levels of NGF, osteogenesis differentiation, and neurogenic differentiation-related genes in the mandible of Beagle dogs. Conclusion Implantation of NGF-CS/HA-coating composite implants has significant induction effects on the early osseointegration and nerve regeneration of peri-implant tissues in the mandible of Beagle dogs.

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“…The osseointegration process of metallic implants, centered on forming a direct interface between the implanted device and the host bone tissue, is important for the stabilization and long-term biomechanical and functional performance of most implants. This complex process consists in (i) early-stage osseointegration (up to one month)-an intimate mechanical-based connection established between the implant and surrounding tissues, leading to initial interactions with resident cells and (ii) late-stage osseointegration (up to six months)-a dynamic molecular and cellular phase resulting in regional bone healing, new bone formation and bone remodeling [17,18].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

Gherasim

Grumezescu

et al. 2021

Antibiotics

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The occurrence of opportunistic local infections and improper integration of metallic implants results in severe health conditions. Protective and tunable coatings represent an attractive and challenging selection for improving the metallic devices’ biofunctional performances to restore or replace bone tissue. Composite materials based on hydroxyapatite (HAp), Kanamycin (KAN), and fibroblast growth factor 2 (FGF2) are herein proposed as multifunctional coatings for hard tissue implants. The superior cytocompatibility of the obtained composite coatings was evidenced by performing proliferation and morphological assays on osteoblast cell cultures. The addition of FGF2 proved beneficial concerning the metabolic activity, adhesion, and spreading of cells. The KAN-embedded coatings exhibited significant inhibitory effects against bacterial biofilm development for at least two days, the results being superior in the case of Gram-positive pathogens. HAp-based coatings embedded with KAN and FGF2 protein are proposed as multifunctional materials with superior osseointegration potential and the ability to reduce device-associated infections.

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The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs

Abstract: LMHF loading positively influenced peri-implant bone healing in the early healing period.

Cited by 6 publications

References 25 publications

Does Low-Magnitude High-Frequency Vibration (LMHFV) Worth for Clinical Trial on Dental Implant? A Systematic Review and Meta-Analysis on Animal Studies

Does Low-Magnitude High-Frequency Vibration (LMHFV) Worth for Clinical Trial on Dental Implant? A Systematic Review and Meta-Analysis on Animal Studies

Nerve growth factor-chondroitin sulfate/hydroxyapatite-coating composite implant induces early osseointegration and nerve regeneration of peri-implant tissues in Beagle dogs

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

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