The effect of low level laser irradiation on oxidative stress, muscle damage and function following neuromuscular electrical stimulation. A double blind, randomised, crossover trial

Abstract

BackgroundLow level laser therapy (LLLT) is among novel methods for preventing and treating muscle damage and soreness induced by volitional exercise, but little is known about using LLLT before neuromuscular electrical stimulation. The aim of this first randomised, double blind, crossover trial addressing this issue was to evaluate effects of LLLT on muscle damage and oxidative stress, as well as recovery of muscle function after a single session of isometric neuromuscular electrical stimulation(NMES).MethodsTwenty four moderately active, healthy men aged 21–22 years received 45 electrically evoked tetanic, isometric contractions of the quadriceps femoris, preceded by LLLT or sham-LLLT. Maximal isometric voluntary muscle torques, perceived soreness, and blood samples were analysed from baseline to 96 h post intervention. We measured plasma markers of muscle damage (the activity of creatine kinase), and inflammation (C-reactive protein), and evaluated redox state parameters.ResultsNMES-evoked contractions induced oxidative stress, demonstrated by an increase in lipid peroxidation and impairments in enzymatic antioxidant system. LLLT irradiations had a protective effect on NMES-induced decrease in enzymatic antioxidant defence and shortened the duration of inflammation. This effect of irradiations on redox state and inflammation did not affect lipid peroxidation, muscle damage, and muscle torque.ConclusionsLLLT may protect from impairments in enzymatic antioxidant system and may shorten inflammation induced by a single NMES session in moderately active, healthy men. However, the effects of LLLT on redox state and inflammatory processes do not seem to affect muscle damage and recovery of muscle function after NMES.Trial registrationThe study was retrospectively registered in the Australian New Zealand Clinical Trials Registry (ANZCTR); The trial registration number: ACTRN12619000678190; date of registration: 6 May 2019.

Orthokeratology and Low-Intensity Laser Therapy for Slowing the Progression of Myopia in Children

“…Currently, vast quantities of empirical evidence have indicated that oxidative stress and inflammation may account for the altered regulatory pathways in myopia and that oxidative damage associated with hypoxic myopia can alter the neuromodulation of nitric oxide and dopamine during eye growth [ 4 , 5 ]. Analyzing the possible mechanisms of the inhibitory effects of LLLT treatment on myopia could help to protect patients from the effects of oxidative stress and decrease inflammation that accompanies myopia [ 27 ]. LLLT has maximal effects on the nitric oxide system and decreases the severity of oxidative stress in both animal studies [ 28 ] and clinical studies [ 29 – 31 ].…”

An Overview on How Exercise with Green Tea Consumption Can Prevent the Production of Reactive Oxygen Species and Improve Sports Performance

“…Five to six weeks of green tea consumption increased the athlete’s antioxidant capacity, which in turn increased the level of total antioxidants in plasma during and after an intense running exercise session as well as prevented or inhibited excessive lipid peroxidation caused by the exercise. Several studies have shown that green tea has a protective effect (i.e., increased plasma antioxidant and decreased plasma lipid hydroperoxide levels) against oxidative stress produced during and after exercise [ 58 , 59 ]. In addition, green tea consumption inhibits or reduces plasma creatine kinase and xanthine oxidase activities after exercise.…”

Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study

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