The purpose of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on inflammation, the oxidative/antioxidant balance, and muscle damage after acute exercise in normobaric, normoxic (NN) and hypobaric, hypoxic (HH) environments. Eighteen healthy males were selected and randomly assigned to three groups: exercise in NN conditions (NN group, n = 6), HBOT treatment after exercise in NN conditions (HNN group, n = 6), and HBOT treatment after exercise in HH conditions (HHH group, n = 6). All subjects performed treadmill running for 60 min at 75–80% maximum heart rate (HRmax) exercise intensity under each condition. The HBOT treatments consisted of breathing 100% oxygen at 2.5 atmosphere absolute (ATA) for 60 min. Blood samples were collected before exercise (BE), after exercise (AE), and after HBOT (AH) to examine inflammation (fibrinogen, interleukin-6 [IL-6], and tumor necrosis factor-α (TNF-α)), the oxidative/antioxidant balance (derivatives of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP)), and muscle damage (creatine kinase (CK) and lactate dehydrogenase (LDH)). Plasma fibrinogen, serum IL-6, CK, and LDH levels were significantly increased AE compared to BE in all groups (p < 0.05). Plasma fibrinogen levels were significantly decreased AH compared to AE in all groups (p < 0.05), and the HNN group had a significantly lower AH compared to BE (p < 0.05). Serum IL-6 levels were significantly decreased AH compared to AE in the HNN and HHH groups (p < 0.05). Serum CK levels were significantly decreased AH compared to AE in the HHH group (p < 0.05). Serum LDH levels were significantly decreased AH compared to AE in the HNN and HHH groups (p < 0.05), and the NN and HNN groups had significantly higher AH serum LDH levels compared to BE (p < 0.05). These results suggest that acute exercise in both the NN and HH environments could induce temporary inflammatory responses and muscle damage, whereas HBOT treatment may be effective in alleviating exercise-induced inflammatory responses and muscle damage.

The purpose of this study was to examine the effect of D-ribose supplementation on the changes of blood fatigue substances (lactate, ammonia, phosphate and hypoxanthine) after maximal exercise performance in college male students. The experimental trials of each subject were divided into the following conditions: placebo supplement trial and D-ribose supplement trial. The subjects exercised using a Concept Ⅱ Indoor rowing ergometer for 2,000 m Single Skull event. The subjects ingested 200 mg/kg of D-ribose after breakfast, lunch, dinner, as well as thirty minutes before exercising, for six days. Blood fatigue substances were continuously measured before exercise, immediately after exercise, and thirty minutes after exercise. The results indicated a significant difference in blood phosphate and hypoxanthine levels between the two experimental trials in the 30 minute recovery period (p<0.05). However, there were no significant differences in blood lactate and phosphate levels between the two experimental trials. The results of our study suggest that D-ribose supplementation during maximal rowing exercise for 7~8 minutes may contribute to the improvement of metabolic responses as a beneficial ergogenic aid accelerating fatigue clearance.

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