The effect of low-intensity laser therapy (LILT) on cutaneous wound healing and pain relief in rats

Koo, Hyun-Mo; Yong, Min-Sik; Na, Sang-Su

doi:10.1589/jpts.27.3421

Cited by 12 publications

(14 citation statements)

References 25 publications

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“…LLLT is applied to reduce pain [28,29] and inflammatory conditions [14,30] and to accelerate bone growth [15,31] as well as wound and ulceration healing [13,32]. Research on LLLT as a method of preventing or alleviating delayed onset muscle soreness has started to be carried out only recently [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, recent years have seen an increased interest in the application of low-level laser therapy (LLLT) and lightemitting diode therapy (LEDT). There are numerous studies describing the effectiveness of LLLT and LEDT in wound healing [13], inflammation reduction [14], or bone healing [15]. It has been reported that LLLT may prove beneficial in preventing and reducing the intensity of delayed onset muscle soreness and may accelerate post-exercise recovery when applied shortly before training [16].…”

Section: Original Research Papersmentioning

confidence: 99%

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Low-Level Laser Therapy and the Recovery of Muscle Function After a Single Session of Neuromuscular Electrical Stimulation: A Crossover Trial

Cieśliński

Jówko

Sacewicz

et al. 2018

Polish Journal of Sport and Tourism

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Introduction. Neuromuscular electrical stimulation is applied in muscle atrophy and in muscle strength and endurance training in athletes. Muscle soreness and temporary reduction in muscle strength may occur as adverse effects. Laser therapy has been used as a method of counteracting delayed onset muscle soreness following volitional exercise, but not following electrical stimulation. The aim of the study was to determine whether low-level laser therapy applied prior to electrical stimulation accelerates the recovery of muscle strength and decreases the duration and intensity of muscle soreness at rest after intensive isometric neuromuscular electrical stimulation of the quadriceps femoris muscle. Material and methods. A randomised crossover trial was carried out on 24 healthy, recreationally active men aged 22-24 years. Low-level laser therapy or sham laser therapy was applied prior to a single session of neuromuscular electrical stimulation of the quadriceps femoris muscle with typical technical and training-related parameters. Irradiations were performed immediately prior to and shortly after electrical stimulation as well as 24, 48, 72, and 96 hours after this procedure. Muscle soreness was examined using the VAS scale in the same time periods. Quadriceps moments of force were recorded with the use of a Biodex 4 Pro device during maximum voluntary static contraction and during electrical stimulation that triggered a tetanic contraction of the quadriceps femoris muscle reaching the level of maximum tolerance. Results. No significant differences were noted in the severity of quadriceps soreness and in the magnitude of the decrease in the moments of force of maximum voluntary contractions after stimulation preceded by laser therapy and that preceded by sham irradiations. Conclusions. In the group studied, laser therapy applied before single electrical stimulation with typical parameters did not bring about a faster recovery of muscle strength or a more rapid decrease in soreness than sham laser therapy used prior to electrical stimulation. Further research on larger groups of subjects with the application of various procedures as well as research on training programmes is needed.

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Section: Discussionmentioning

confidence: 99%

Section: Original Research Papersmentioning

confidence: 99%

Low-Level Laser Therapy and the Recovery of Muscle Function After a Single Session of Neuromuscular Electrical Stimulation: A Crossover Trial

Cieśliński

Jówko

Sacewicz

et al. 2018

Polish Journal of Sport and Tourism

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“…The results of this study indicate that protein malnutrition has a negative effect on wound healing. The classic model of cutaneous healing adopted in this experimental study has been described in the literature as being reproducible and effective in illustrating processes that occur naturally in humans [13,14]. Thus, the observed transformations in the connective tissue matrix suggest that balanced nutrition represents a determining factor for establishing a good healing pattern.…”

Section: Discussionmentioning

confidence: 87%

“…The rats of both groups (M and N) were anesthetized with a mixture of ketamine and xylazine at the rate of 0.2ml/100 grams in weight. After performing trichotomy of the dorsal region with a razor blade, standardized cutaneous wounds [13,14] were made with a circular 8mm diameter scalpel (Biopsy Punch, Stiefel ® , Köln, Germany).…”

Section: Surgical Procedure Sacrifice and Histological Processingmentioning

confidence: 99%

Influence of protein malnutrition on cutaneous wound healing in rats

et al. 2018

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Objective Investigate histological changes related to inflammatory response and collagen expression during wound healing in rats with protein malnutrition. Methods Twenty male Wistar rats underwent cutaneous surgery and were divided into two experimental groups: Malnourished (8% casein diet); Nourished (17% casein diet). Animals were euthanized after 5th and 10th days, descriptive and quantitative analyses were performed on sections stained with hematoxylin-eosin and sirius red, respectively. Statistical analysis of data using nonparametric Fisher's exact test with p<0.05 was carried out. Results At five days, increased fibroblast proliferation (p<0.01) and collagen expression (p<0.05) was observed in N5 group. After ten days, N10 and MN10 animals showed higher amount of granulation tissue and edema/inflammatory infiltrate independent of nutritional status (p>0.05), only N10 group showed fibroblast proliferation (p<0.01) and increased collagen expression (p<0.01). Conclusion Protein malnutrition seems not to influence inflammatory phase of healing, whereas it negatively effects fibroblast proliferation and collagen synthesis.

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“…Wound healing is a complex event that develops in three interrelated phases: inflammatory, proliferative and remodeling. In this process a dynamic interaction occurs between the extracellular matrix, growth factors, and cells [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The photobiomodulation (658, 830 and 904nm) on wound healing in histomorphometric analysis

et al. 2020

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A fotobiomodulação (658, 830 e 904nm) na cicatrização de feridas na análise histomorfométrica La fotobiomodulación (658, 830 y 904nm) en la cicatrización de heridas en el análisis histomorfométrico Abstract Introduction: Photobiomodulation (PBM) assists in the processes of angiogenesis and cellular mitosis after skin lesion, contributing to tissue repair. Objective: to investigate the effects of photobiomodulation (during the proliferative phase) of 658 nm, 830 nm and 904 nm in the repair of skin lesions in an animal model. Method: 658 nm (G658), 830 nm (G830), 904 nm (G904) PBM, and control group (CG) integrated the research. We submitted the animals to an excisional wound and treatment at different wavelengths for 14 days. On the seventh and 14-1485004059 th postoperative days, we calculated the area and percentage of lesion contraction. The animals were sacrificed on the 14-1485004056 th postoperative day and cutaneous section of the injured region was collected for histomorphometric evaluation of the cellularity, neovascularization, thickness of the epidermis and volume density of collagen fibers colored with H&E and Picross Sirius respectively. For the statistical analysis, we applied the ANOVA test. Results: the G658 presented higher cellularity than GC (p = 0.03). The animals in the G658 group showed a significant increase in the neovascularization in relation to the CG (p = 0.01). Type III collagen significantly increased in G904 compared to G830 (p < 0.0001) and CG (p < 0.0001). The G658 had a * LSB: Master student, significant increase in type III collagen fibers compared to G830 (p < 0.0001) and GC (p < 0.0001). We found no significant difference in the thickness of the epidermis, wound area, and in the percentage wound of contraction between the analyzed groups. Conclusion: PBM was effective to stimulate the tissue repair process, with better results for the 658 nm wavelength.Introdução: A Fotobiomodulação (FBM) auxilia nos processos de angiogênese e mitose celular após lesão cutânea, contribuindo para reparo do tecido. Objetivo: investigar os efeitos da fotobiomodulação (durante a fase proliferativa) com comprimento de onda de 658 nm, 830 nm e 904 nm no reparo de lesões cutâneas em modelo animal. Método: FBM 658 nm (G658), 830 nm (G830), 904 nm (G904) e controle (GC) integraram a pesquisa. Os animais foram submetidos a uma ferida excisional e receberam tratamento em diferentes comprimentos de por 14 dias. No 7º e 14º dia pós-operatório, calculou-se a área e a porcentagem de contração da lesão. Os animais foram sacrificados no 14º dia pós-operatório e a secção cutânea da região lesada foi coletada para avaliação histomorfométrica da celularidade, neovascularização, espessura da epiderme e densidade volumétrica das fibras colágenas, corados com H&E e Picross Sirius respectivamente. Para a análise estatística, foi aplicado o teste ANOVA. Resultados: o G658 apresentou maior celularidade que GC (p = 0,03). Os animais do grupo G658 apresentaram aumento significativo da neovascularização em relação ao GC (p...

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The effect of low-intensity laser therapy (LILT) on cutaneous wound healing and pain relief in rats

Cited by 12 publications

References 25 publications

Low-Level Laser Therapy and the Recovery of Muscle Function After a Single Session of Neuromuscular Electrical Stimulation: A Crossover Trial

Low-Level Laser Therapy and the Recovery of Muscle Function After a Single Session of Neuromuscular Electrical Stimulation: A Crossover Trial

Influence of protein malnutrition on cutaneous wound healing in rats

The photobiomodulation (658, 830 and 904nm) on wound healing in histomorphometric analysis

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