The effect of low dose epinephrine infusion on hepatic hemodynamics

Marsh, John; Drougas, James G.; Wright, J. Kelly; Chapman, William C.; Becker, Yolanda T.; Barnard, Sue Ellen; Donovan, Kevin; Feurer, Irene D.; Sika, Mohammed; Blair, K.Taylor; Hamilton, Kamisha; Pinson, C. Wright

doi:10.1016/s0041-1345(98)00633-2

Cited by 3 publications

(6 citation statements)

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“…It must be emphasized that a review of all available data currently does not allow a conclusion. Although some groups have described a dose‐dependent increase of HAF and PVF after Epi administration,15 others have found a decreased HAF and PVF at low dosages 48. In the native liver group, we could show that PVF and THF values were significantly correlated during Epi and NorEpi infusion whereas HAF and PVF did not show a significant correlation.…”

Section: Discussionmentioning

confidence: 51%

“…Pharmacologic interventions, particularly administration of vasoactive drugs, may affect liver graft perfusion,13 usually in a dose‐dependent manner 14. Potential side effects of catecholamine therapy include microcirculation disturbances of intraabdominal organs, such as liver, kidney, and intestine 15. Only limited information is so far available on the effect of catecholamines, on liver perfusion.…”

mentioning

confidence: 99%

“…Effects of dopamine have been assessed in multiple studies,16–18 with the kidney being the most studied intraabdominal organ 19. In contrast, data on epinephrine (Epi) or norepinephrine (NorEpi) effects on perfusion of visceral organs are rather scarce 15, 20. Although negative effects of catecholamines on hepatic macroperfusion and microperfusion and oxygenation in healthy settings as well as ex situ models have been described in some investigations of native livers,21 to the best of our knowledge, no experimental or clinical investigations have been published that specifically analyzed the effects of catecholamine therapy on the hemodynamics of transplanted livers in the early postoperative period.…”

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confidence: 99%

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Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Mehrabi¹,

Golling²,

Kashfi³

et al. 2005

Liver Transpl

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Catecholamines are often administered during and after liver transplantation (LTx) to support systemic perfusion and to increase organ oxygen supply. Some vasoactive agents can compromise visceral organ perfusion. We followed the hypothesis that the vasculature of transplanted livers presents with a higher sensitivity, which leads to an increased vulnerability for flow derangement after application of epinephrine (Epi) or norepinephrine (NorEpi).

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Section: Discussionmentioning

confidence: 51%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Mehrabi¹,

Golling²,

Kashfi³

et al. 2005

Liver Transpl

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“…The first piecewise slope (b ϭ Ϫ0.29) over 4 unit change increments (0, 3, 6, 9, 12) was not significant (P ϭ 0.63). The second piecewise slope (b ϭ 2.12) over 6 unit change increments (12,15,18,21,24,27,30) was statistically significant (P Ͻ 0.001).…”

Section: Discussionmentioning

confidence: 94%

“…If hypotension cannot be controlled with adequate fluid resuscitation and dopamine up to 10 g/kg/min, further increases in dosage can augment hepatic blood flow by more than 20%. With other organ systems in mind, epinephrine doses around 0.1 g/kg/min should also be considered [18,19].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dopamine Infusion (3–30 μg/kg/min) on Hepatic Hemodynamics

Giullian

Marsh

Chung

et al. 2000

Journal of Surgical Research

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Intravenous Infusion of Cortisol, Adrenaline, or Noradrenaline Alters Porcine Immune Cell Numbers and Promotes Innate over Adaptive Immune Functionality

Reiske

Schmucker

Pfaffinger

et al. 2020

The Journal of Immunology

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Despite the importance of pigs (Sus scrofa domestica) in livestock production and their increasing role as a model organism for human physiology, knowledge about the porcine immune system under the influence of stress hormones is fragmentary. Exceptionally little is known about the effects of catecholamines. Therefore, the aim of this study was to examine the in vivo effects of adrenaline, noradrenaline, and cortisol on number and functionality of porcine blood immune cells. Castrated male pigs (n = 34) were treated with physiological doses of either adrenaline, noradrenaline, or cortisol via i.v. infusion for 48 h. Blood samples were collected before treatment (224 h, 222 h, 0 h), during treatment (+2 h, +24 h, +48 h), and at 72 h postinfusion. Immune cell numbers and phagocytic activity were evaluated by flow cytometry and lymphocyte proliferation by 3 H-thymidine incorporation. Total IgG and IgM Ab levels were determined via ELISA. Pigs receiving cortisol showed strongly decreased adaptive immune cell numbers and increased neutrophils, accompanied by hampered lymphocyte proliferation but increased monocyte phagocytosis. Catecholamine effects on immune cell numbers were mostly similar to cortisol in direction but smaller in intensity and duration. Lymphocyte proliferation was inhibited after 2 h of noradrenaline infusion, and both catecholamines promoted monocyte and neutrophil phagocytosis. These findings indicate a shift from adaptive to innate immunity in stressful situations. This study is the first (to our knowledge) to systematically investigate specific glucocorticoid and catecholamine actions on the porcine immune system in this level of detail and confirms many similarities to humans, thus strengthening the pig as a human model in psychoneuroimmunology.

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The effect of low dose epinephrine infusion on hepatic hemodynamics

Cited by 3 publications

References 10 publications

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Effect of Dopamine Infusion (3–30 μg/kg/min) on Hepatic Hemodynamics

Intravenous Infusion of Cortisol, Adrenaline, or Noradrenaline Alters Porcine Immune Cell Numbers and Promotes Innate over Adaptive Immune Functionality

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