Effect of Dopamine Infusion (3–30 μg/kg/min) on Hepatic Hemodynamics

Giullian, Jeffrey; Marsh, John; Chung, O.K; Drougas, James G.; Wright, J. Kelly; Chapman, William C.; Blair, K.Taylor; Barnard, Sue Ellen; Feurer, Irene D.; Pinson, C. Wright

doi:10.1006/jsre.1999.5787

Cited by 6 publications

(6 citation statements)

References 10 publications

(11 reference statements)

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“…Previously, dopamine has been demonstrated to influence splanchnic blood flow [10,31,40]. Dopamine is an inotropic substance with different influences on the pressure tone of the vascutature [10].…”

Section: Discussionmentioning

confidence: 99%

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Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery

et al. 2002

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Section: Discussionmentioning

confidence: 99%

“…Dopamine is an inotropic substance with different influences on the pressure tone of the vascutature [10]. At low-doses, dopamine stimulates predominantly dopaminergic D lreceptors with a vasodilating effect on renal and mesenteric vessels [10,31,40].…”

Section: Discussionmentioning

confidence: 99%

Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery

et al. 2002

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“…Maintenance of the stability of hepatosplanchnic circulation is especially important for organ donors to preserve normal organ function after transplantation. Because high‐dose DA elevates systemic arterial blood pressure through increasing the heart rate and peripheral vascular resistance, it is widely used as the first‐line vasopressor in potential organ donors with a failing brain stem to boost systemic hemodynamics, thereby facilitating adequate perfusion of vital organs and theoretically maintaining their functional integrity …”

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confidence: 99%

“…Although low‐dose DA has been shown to increase renal blood flow in both experimental and clinical studies, the rationale of its widespread use in the intensive care unit has been challenged by a lack of tangible therapeutic benefits after systemic reviews of literature . Similarly, despite the lack of detrimental effects on hepatic hemodynamics associated with high‐dose DA, there are still reports showing that high‐dose DA has a tangible suppressive effect on the growth of neural and renal cells in vitro and exhibits cytotoxicity . Consistently, high‐dose DA has long been known to be a detrimental factor in screening for organs from deceased donors .…”

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confidence: 99%

Dopamine impairs functional integrity of rat hepatocytes through nuclear factor kappa B activity modulation: An in vivo, ex vivo, and in vitro study

et al. 2015

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Dopamine (DA) is commonly used to maintain the hemodynamic stability of brain-dead donors despite its controversial effects on organ functions. This study aimed at examining the hemodynamic effect of DA in a rat brain-dead model in vivo, alteration of hepatocyte integrity in liver grafts after ex vivo preservation, and changes in cultured clone-9 hepatocytes including cellular viability, cell cycle, apoptotic regulators, and lipopolysaccharide (LPS)-stimulated nuclear factor kappa B (NF-jB) signaling machinery. Although in vivo findings demonstrated enhanced portal venous blood flow and hepatic microcirculatory perfusion after DA infusion, no apparent advantage was noted in preserving hepatocyte integrity ex vivo. In vitro, prolonged exposure to high-dose DA reduced proliferation and induced G 1 growth arrest of clone-9 hepatocytes with concomitant decreases in B cell lymphoma 2 (BCL2)/B cell lymphoma 2-associated X protein (BAX) and heat shock protein 70/BAX protein ratios and intracellular NF-jB p65. Moreover, DA pretreatment suppressed LPS-elicited inhibitor of jBa phosphorylation and subsequent NF-jB nuclear translocation, suggesting that DA may down-regulate NF-jB signaling, thereby reducing expression of antiapoptotic regulators, such as BCL2. In conclusion, despite augmentation of hepatic perfusion, DA infusion failed to preserve hepatocyte integrity both in vivo and ex vivo. In vitro findings demonstrated that highdose DA may hamper the function of NF-jB signaling machinery and eventually undermine functional integrity of hepatocytes in liver grafts. Liver Transpl 21:1520-1532, 2015. V C 2015 AASLD.Received May 4, 2015; accepted September 11, 2015. Dopamine (DA) is a neurotransmitter structurally belonging to the catecholamine family (3,4-dihydroxyphenylethylamine) and well studied for its role in mental functioning including thinking and feeling. 1 DA is also one of the most popular medications being used in the intensive care unit for maintaining Additional supporting information may be found in the online version of this article.

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“…The first step usually is intravenous fluid administration. However, if volume replacement is not sufficient to overcome systemic hypotension or impaired ventricular function, intravenous catecholamines are often administered 12. Approximately 20% of patients receive catecholamines in this clinical phase of LTx 7…”

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confidence: 99%

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

Mehrabi¹,

Golling²,

Kashfi³

et al. 2005

Liver Transpl

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Catecholamines are often administered during and after liver transplantation (LTx) to support systemic perfusion and to increase organ oxygen supply. Some vasoactive agents can compromise visceral organ perfusion. We followed the hypothesis that the vasculature of transplanted livers presents with a higher sensitivity, which leads to an increased vulnerability for flow derangement after application of epinephrine (Epi) or norepinephrine (NorEpi).

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Effect of Dopamine Infusion (3–30 μg/kg/min) on Hepatic Hemodynamics

Cited by 6 publications

References 10 publications

Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery

Impact of dopamine and endothelin-1 antagonism on portal venous blood flow during laparoscopic surgery

Dopamine impairs functional integrity of rat hepatocytes through nuclear factor kappa B activity modulation: An in vivo, ex vivo, and in vitro study

Negative impact of systemic catecholamine administration on hepatic blood perfusion after porcine liver transplantation

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