The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial

Davar, Robab; Pourmasumi, Soheila; Mohammadi, Banafsheh; Lahijani, Maryam Mortazavi

doi:10.18502/ijrm.v13i9.7664

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…The artificial cycle is a process of simulating the action of the natural ovulation cycle hormone changes on the endometrium, thereby affecting the receptivity of the endometrium. Numerous studies have favored the use of natural cycles for endometrial preparation, concerning the safety of drugs for endometrial preparation and pregnancy rates [ 5 , 6 ]. However, it is worth noting that the artificial cycle can choose the best time for embryo transfer, with a low cancellation rate.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Relevant Factors Affecting the Pregnancy Rate of Frozen-Thawed Embryo Transfer Cycle

Liu

Wang

Lü

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to explore the relevant factors affecting the pregnancy rate of frozen-thawed embryo transfer cycle. Methods. The clinical data of 931 patients who underwent artificial cycle preparation for endometrial FET from April 2017 to November 2020 in the reproductive center of our hospital were retrospectively analyzed. Results. According to the pregnancy situation, the patients were divided into 450 cases of pregnancy and 481 cases of biochemical pregnancy. The univariate analysis of FET biochemical pregnancy showed that there were statistically significant differences between pregnancy and biochemical pregnancy in terms of years of infertility, age, endometrial thickness, P level, E2/P, and the number of high-quality embryos ( P < 0.05 ). Multivariate analysis of pregnancy showed that age <30 years was a protective factor for biochemical pregnancy and endometrial thickness <8 mm and E2/P < 0.3 were risk factors ( P < 0.05 ). Conclusion. The regulation of endometrial thickness and E2/P serves as the key of treatment for patients undergoing FET using artificial cycle preparation for endometrial transfer, and it contributes to improve the pregnancy rate; also, the patient's age is an important indicator influencing the pregnancy rate.

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Section: Introductionmentioning

confidence: 99%

Analysis of Relevant Factors Affecting the Pregnancy Rate of Frozen-Thawed Embryo Transfer Cycle

Liu

Wang

Lü

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In one previous randomized controlled clinical trial carried out by Davar et al . (12) , there was no statistically significant difference between the two groups (aspirin versus no therapy), and both the chemical and clinical pregnancy rates and the abortion rate were similar (12) . Madani et al (13) in reported that, in contrast to our findings, aspirin administration during ICSI cycles increased the rates of implantation, clinical pregnancy, and live births (12) .…”

Section: Discussionmentioning

confidence: 90%

“…(12) , there was no statistically significant difference between the two groups (aspirin versus no therapy), and both the chemical and clinical pregnancy rates and the abortion rate were similar (12) . Madani et al (13) in reported that, in contrast to our findings, aspirin administration during ICSI cycles increased the rates of implantation, clinical pregnancy, and live births (12) . In 2000, Hsieh and colleagues (14) found that taking aspirin increased the clinical pregnancy rate, but they select women with thin endometrium (14) .…”

Section: Discussionmentioning

confidence: 90%

Effectiveness of Low Dose Aspirin or Vaginal Sildenafil on Perifollicular Blood Flow Using Doppler ultrasound and EG-VEGF and their Impacts on ICSI Cycle Outcome

Mohammed¹,

Hussaini²,

ALjubori³

2022

The Egyptian Journal of Hospital Medicine

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Background: Aspirin low dose or vaginal sildenafil, the two drugs have been shown to be advantageous for women undergoing assisted conception. Using powerful Doppler imaging, it is now possible to identify perifollicular perfusion and hence the accurate selection of oocyte with good intracytoplasmic sperm injection (ICSI) outcome. Objective: The current study aimed to investigate the effects of aspirin and vaginal sildenafil citrate on improvement of the perifollicular blood flow, EG-VEGF and conception in females following ICSI cycles. Subjects and methods: Ninety infertile women were participated in ICSI cycles. Full investigation was made for participating women. Ovarian stimulation protocol was performed. Doppler ultrasonography was used to evaluate the perifollicular blood flow. Serum and follicular fluid EG-VEGF were measured. data analyzed using SSPS program. Results: Total oocytes count was significantly higher in aspirin group in comparison with sildenafil and control group. No significant difference in mean serum and follicular fluid EG-VEGF. Also, no significant difference in the proportions of PFBF and endometrial vascular zones. With respect to endometrial vascular zones, there was significant variation in favor of sildenafil and aspirin groups. Positive pregnancy test was reported in 40.0% of women in aspirin group, in (33.3 %) of women in sildenafil group and in (20.0 %) of women in placebo group, the difference was insignificant. Conclusion: Aspirin treatment resulted in higher number of total retrieved oocytes, aspirin and sildenafil did not improve endometrial thickness, but they resulted in an improvement of sub endometrial vascularity, however, biochemical pregnancy test was not affected by either pharmacological agent.

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“…The endometrial thickness was actually lower (8.64 ± 1.60 vs. 9.29 ± 1.70; P = 0.028) in patients who received aspirin in comparison to the control group. Chemical and clinical pregnancy rates were not different [29 ▪ ].…”

Section: Vitamins and Supplementsmentioning

confidence: 81%

Treatment options for endometrial hypoproliferation

Çakıroğlu

Tıraş

Franasiak

et al. 2023

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewEndometrial hypoproliferation refers to the failure of the endometrium to reach optimal thickness during fresh or frozen embryo transfer cycles in women undergoing infertility treatment with in-vitro fertilization (IVF). This review discusses the treatment options for endometrial hypoproliferation. Recent findingsApart from factors related to the embryo quality, ultrasonographic findings associated with the endometrium, such as endometrial thickness, endometrial pattern and subendometrial blood flow, are considered key factors associated with the outcome of assisted reproductive treatment. To date, a consensus has not been reached regarding the definition of thin endometrium, while thresholds of 6, 7 or 8 mm have been used in the literature. Strategies to increase endometrial thickness can be reviewed in three groups: endocrine approaches, vitamins & supplements, and new experimental therapeutic interventions. Some of the recently introduced experimental therapeutic interventions such as platelet-rich plasma injection, stem cell treatment and tissue bioengineering are exciting potential therapies that need to be further studied. SummaryDespite a large number of publications on the topic, diagnosing and treating endometrial hypoproliferation remains a challenge. Well designed studies are needed to establish a widely accepted endometrial thickness cut-off value below which endometrial hypoproliferation is diagnosed and to generate meaningful data that would allow an evidence-based discussion of available therapeutic options with patients.

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The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial

Cited by 5 publications

References 25 publications

Analysis of Relevant Factors Affecting the Pregnancy Rate of Frozen-Thawed Embryo Transfer Cycle

Analysis of Relevant Factors Affecting the Pregnancy Rate of Frozen-Thawed Embryo Transfer Cycle

Effectiveness of Low Dose Aspirin or Vaginal Sildenafil on Perifollicular Blood Flow Using Doppler ultrasound and EG-VEGF and their Impacts on ICSI Cycle Outcome

Treatment options for endometrial hypoproliferation

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