The Effect of Long-term Space Flights on Human Urine Proteins Functionally Related to Endothelium

Пастушкова, Л. Х.; Каширина, Д. Н.; Kononikhin, Alexey; Brzhozovsky, A. G.; Иванисенко, В. А.; Tiys, Evgeny S.; Novosyolova, A. M.; Custaud, Marc‐Antoine; Nikolaev, Evgeny N.; Ларина, И. М.

doi:10.1134/s0362119718010139

Cited by 3 publications

(1 citation statement)

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“…Such changes could be associated with endothelium and blood vessel integrity. Spaceflight modifies the functions of endothelial cells which also contributes to the changes in hemostasis [33]. We suppose that observed changes demonstrate physiological adaptation to spaceflight conditions.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Spaceflight Factors on the Human Plasma Proteome, Including Both Real Space Missions and Ground-Based Experiments

Brzhozovskiy

Kononikhin

Пастушкова

et al. 2019

IJMS

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The aim of the study was to compare proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based experiments. LC–MS/MS-based proteomic analysis of blood plasma samples obtained from 13 cosmonauts before and after long-duration (169–199 days) missions on the International Space Station (ISS) and for five healthy men included in 21-day-long head-down bed rest (HDBR) and dry immersion experiments were performed. The semi-quantitative label-free analysis revealed significantly changed proteins: 19 proteins were significantly different on the first (+1) day after landing with respect to background levels; 44 proteins significantly changed during HDBR and 31 changed in the dry immersion experiment. Comparative analysis revealed nine common proteins (A1BG, A2M, SERPINA1, SERPINA3, SERPING1, SERPINC1, HP, CFB, TF), which changed their levels after landing, as well as in both ground-based experiments. Common processes, such as platelet degranulation, hemostasis, post-translational protein phosphorylation and processes of protein metabolism, indicate common pathogenesis in ground experiments and during spaceflight. Dissimilarity in the lists of significantly changed proteins could be explained by the differences in the dynamics of effective development in the ground-based experiments. Data are available via ProteomeXchange using the identifier PXD013305.

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Section: Resultsmentioning

confidence: 99%