Piloted space flight and post-genomic technologies

Ларина, И. М.; Пастушкова, Л. Х.; Кононихин, А. С.; Nikolaev, E. N.; Орлов, О. И.

doi:10.1016/j.reach.2020.100034

Cited by 1 publication

(1 citation statement)

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“…Proteomic approach attracts considerable attention in the study of physiological and pathological changes. Several recent reviews describe the effect of microgravity on the animal and human proteomes [ 83 , 84 , 85 , 86 , 87 ]. Over the past few years, mass spectrometry has become the method of choice for the characterization of ECM composition [ 40 , 88 , 89 ] and has been shown to offer new bioinformatic approaches of translating data from the putative biomarkers to the elucidation of new therapeutic targets [ 90 , 91 , 92 ].…”

Section: Proteomic Profile Of Human Matrisome-associated Proteins Under Real and Simulated Microgravitymentioning

confidence: 99%

Microgravity Effects on the Matrisome

Буравкова

Ларина

Андреева

et al. 2021

Cells

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Gravity is fundamental factor determining all processes of development and vital activity on Earth. During evolution, a complex mechanism of response to gravity alterations was formed in multicellular organisms. It includes the “gravisensors” in extracellular and intracellular spaces. Inside the cells, the cytoskeleton molecules are the principal gravity-sensitive structures, and outside the cells these are extracellular matrix (ECM) components. The cooperation between the intracellular and extracellular compartments is implemented through specialized protein structures, integrins. The gravity-sensitive complex is a kind of molecular hub that coordinates the functions of various tissues and organs in the gravitational environment. The functioning of this system is of particular importance under extremal conditions, such as spaceflight microgravity. This review covers the current understanding of ECM and associated molecules as the matrisome, the features of the above components in connective tissues, and the role of the latter in the cell and tissue responses to the gravity alterations. Special attention is paid to contemporary methodological approaches to the matrisome composition analysis under real space flights and ground-based simulation of its effects on Earth.

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