The Effect of Local Delivery Doxycycline and Alendronate on Bone Repair

Limirio, Pedro Henrique Justino Oliveira; Rocha, Flaviana Soares; Batista, Jonas Dantas; Guimarães-Henriques, João César; Melo, Geraldo Batista de; Dechichi, Paula

doi:10.1208/s12249-015-0411-0

Cited by 22 publications

(18 citation statements)

References 40 publications

(44 reference statements)

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“…On the other hand, bisphosphonates are proven to be effective in inhibiting bone loss due to their ability of decreasing osteoclastic activity, but are not effective in improving bone density in the bone formation phase (35). Some authors, to further promote bone healing, have combined bisphosphonates with other substances, such as collagen membrane and different graft materials, achieving better bone repair outcomes (30,36). PTH acts by stimulating osteogenesis (2), and is considered the only therapeutic agent recommended for bone formation (37).…”

Section: Discussionmentioning

confidence: 99%

Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study

et al. 2018

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This study aimed to evaluate the effect of two methods of local application of alendronate and parathyroid hormone (PTH) on bone repair and the systemic implications. A critically sized defect (5 mm) was created in the cranial region of twenty-five male Wistar rats, and the bone removed was particulated, and grafted back to the defect with different treatments. The animals were randomly divided into five groups: A1-bone graft immersion in alendronate solution (3 mg/kg) for 5 minutes; P1-bone graft immersion in PTH solution (20 µg); A2-weekly local applications of alendronate 1 mg/kg; P2-weekly local applications of PTH (20 µg); C-no drugs were used. The animals were euthanized 60 days after surgery. Cranial bone blocks were removed for histological, histomorphometric, and immunohistochemical analyses. MMP-2 and MMP-9 were used for immunolabeling. The kidneys, liver, and brain were also removed from all the rats for histological analysis. The data were submitted for statistical analysis with a level of significance of 0.05 (One-way ANOVA). The group C and group P2 presented a higher quantity of viable bone particles than the remaining groups. Groups A1, A2, and P1 presented with fewer viable bone particles than the control group, with a predominance of non-mineralized connective tissue. The histomorphometric analysis revealed no differences in relative bone area or MMP-2 or MMP-9 immunolabeling between the groups (p>0.05). Group A2 showed presence of fat in the liver consistent with hepatic steatosis. Changes in brain tissue were observed in groups A1 and P1. Effect of Local Application of A l e n d r o n a t e a n d Pa r a t h y r o i d Hormone on Craniofacial Bone R e p a i r -a P r e l i m i n a r y S t u d y

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Section: Discussionmentioning

confidence: 99%

Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study

et al. 2018

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“…In this thesis, the broad-spectrum antibiotic doxycycline was chosen as a candidate molecule for such a multifunctional surface modification, since beside its known antibacterial activity, 95 it has also been suggested to promote bone formation. 94,[181][182] Moreover, a beneficial effect of locally released doxycycline has been reported for the treatment of peri-implantitis. 183 The doxycycline coated titanium surfaces produced in this work exhibited antibacterial properties, as demonstrated by the reduced bacterial surface colonization and decreased planktonic bacterial growth of S. epidermidis in paper I.…”

Section: Discussionmentioning

confidence: 99%

Effect of cathodic polarization on coating doxycycline on titanium surfaces

Geißler

Tiainen

2016

Materials Science and Engineering: C

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Cathodic polarization has been reported to enhance the ability of titanium based implant materials to interact with biomolecules by forming titanium hydride at the outermost surface layer. Although this hydride layer has recently been suggested to allow the immobilization of the broad spectrum antibiotic doxycycline on titanium surfaces, the involvement of hydride in binding the biomolecule onto titanium remains poorly understood. To gain better understanding of the influence this immobilization process has on titanium surfaces, mirror-polished commercially pure titanium surfaces were cathodically polarized in the presence of doxycycline and the modified surfaces were thoroughly characterized using atomic force microscopy, electron microscopy, secondary ion mass spectrometry, and angle-resolved X-ray spectroscopy. We demonstrated that no hydride was created during the polarization process. Doxycycline was found to be attached to an oxide layer that was modified during the electrochemical process. A bacterial assay using bioluminescent Staphylococcus epidermidis Xen43 showed the ability of the coating to reduce bacterial colonization and planktonic bacterial growth.

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“…Limirio et al . [ 22 ] investigated the local effect of 10% doxycycline and 1% alendronate combined with poly (lactic-co-glycolic acid) (PLGA) on bone repair by quantifying bone density and resulted association of 10% doxycycline and 1% alendronate with PLGA-accelerated bone repair with significant increase in bone neoformation. Moon et al .…”

Section: Discussionmentioning

confidence: 99%

Comparative clinicoradiographical evaluation of effect of aminobisphosphonate (sodium alendronate) on peri-implant bone status: Controlled clinical trial

Aggarwal

Babaji²,

Nathan

et al. 2016

J Int Soc Prevent Communit Dent

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Aim:The present study aims to compare the peri-implant bone status around immediately loaded dental implants treated with aminobisphosphonate solution and untreated control implants in terms of clinical and radiographical parameters.Materials and Methods:A total of 24 patients were randomly divided equally into two groups. This study was conducted in accordance to the Helsinki's declaration of 1975, revised in 2000, and with the approval of the institutional ethical committee. In the control group after preparation, osteotomy sites were irrigated with normal saline solution, whereas in the test group osteotomy sites were irrigated with modified bisphosphonate solution and then TRX-OP, Hi-Tec dental implants were inserted. Clinical parameters, such as modified plaque and gingival index, probing depth, mobility, and radiographic parameters were recorded at baseline (0), 3, 6, and 9 months. Data analysis was performed using the Statistical Package for the Social Sciences version 17 for windows, and the statistical techniques employed were repeated measures analysis of variance, independent sample t-test, and paired sample t-test.Results:Reduction in mean radiographic bone levels (height) was observed on the mesial and distal aspect of the control group in comparison to its baseline at all intervals. In the test group, there was reduction in mean radiographic bone levels on mesial and distal aspect of the implant site in comparison to its baseline till 6-month follow up, however, at 9 month, there was gain in bone level on both mesial and distal aspect of implant. This represents the effectiveness of sodium alendronate in enhancing the bone formation. On comparison, between both groups on mesial and distal aspect of implants, statistically significant differences were observed at 3 and 9 months on mesial and distal aspect, respectively, without any clinical evidence of mobility in the test group.Conclusion:Implant site treated with aminobisphosphonate solution represents greater efficacy in enhancing bone formation when used as an irrigant; thus, it is considered beneficial in implant dentistry.

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The Effect of Local Delivery Doxycycline and Alendronate on Bone Repair

Cited by 22 publications

References 40 publications

Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study

Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study

Effect of cathodic polarization on coating doxycycline on titanium surfaces

Comparative clinicoradiographical evaluation of effect of aminobisphosphonate (sodium alendronate) on peri-implant bone status: Controlled clinical trial

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