The effect of local application of insulin-like growth factor for prevention of inner-ear damage caused by electrode trauma

Gur, H. Deniz; Alimoğlu, Yalçın; Düzenli, Ufuk; Korkmaz, S; İnan, Sevinç; Olgun, Levent

doi:10.1017/s0022215117000135

Cited by 3 publications

(5 citation statements)

References 15 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study’s hearing threshold shift was greater than other rodent-based CI experimental models [ 18 ]. Although the threshold shift values we obtained in the study were high, another study using the same length (5 mm) of electrode analog also reported high hearing threshold shifts of approximately 65 ± 27 dB [ 17 ].…”

Section: Discussionmentioning

confidence: 72%

See 1 more Smart Citation

The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study

et al. 2022

View full text Add to dashboard Cite

Introduction: During cochlear implantation, electrode insertion can cause cochlear damage, inflammation, and apoptosis, which can affect the residual hearing. Nanoparticles are increasingly studied as a way to increase the availability of inner ear protective factors. We studied the effect on rats of Pluronic-coated gold nanoparticles (Plu-AuNPs) containing dexamethasone, which were applied locally in the rat’s middle ear following the implant procedure. Methods: Seven rats were used in the study. The right ear served as a model for the Dex-Plu-AuNP group. Following the intracochlear dummy electrode insertion through the round window, Dex-Plu-AuNPs were placed in the round window niche. In the right ear, following the same insertion procedure, free dexamethasone (Dex) was placed in the same manner. Auditory brainstem response thresholds (click stimulus, pure tones at 8 kHz, 16 kHz, 24 kHz, and 32 kHz) were measured before and one week after the procedure. A two-tailed T-test was used for the variables. Statistical significance was set as p < 0.05. Results: In the Dex-Plu-AuNP group, the threshold shift was less than that in the free dexamethasone group, but no statistical significance was noted between the groups. When compared individually, only the 8 kHz frequency showed statistically significant, better results after one week, in favor of the Dex-Plu-AuNP group. The mean postoperative 8 kHz threshold in the Dex-Plu-AuNPs was significantly lower than that of the control group (p = 0.048, t-test). For the other frequencies, statistical analysis showed no significant differences between the mean threshold shifts of the two cohorts. Conclusions: The local application of Plu-AuNPs containing dexamethasone following cochlear implantation may better protect the residual hearing than dexamethasone alone, but a larger sample size is needed to reach a possible statistical significance. Dex-Plu-AuNPs do not seem to cause ototoxicity and may be used as a carrier for other agents. In a clinical setting, Dex-Plu-AuNPs may have the effect of protecting lower frequencies in patients with partial deafness who are candidates for electric acoustic stimulation (EAS). If we consider this tendency, Dex-Plu-AuNPs may also be beneficial for patients with Ménière’s disease.

show abstract

Section: Discussionmentioning

confidence: 72%

“…A monofilament 5/0 polypropylene suture (Ethicon ® , Raritan, NJ, USA) with a length of 5 mm was employed for the insertion [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Clinical trials demonstrate that IGF-1 can improve hearing after sudden sensorineural hearing loss [55] but is less effective in mitigating ototoxic drug-induced sensorineural hearing loss [56]. When used in combination with a cochlear implant, either as an eluting gelatin hydrogel coating the electrode [57] or placed locally on the round window membrane in the form of soaked porcine skin gelatin [58], IGF-1 demonstrated protection of the auditory brainstem response (ABR) thresholds and showed better histopathological scores compared to a cochlear implant electrode with no coating.…”

Section: Insulin-like Growth Factormentioning

confidence: 99%

“…Insulin-like growth factor Animal and human studies [55,57,58] Good results were achieved with SNHL; IGF-1-coated electrodes showed better ABR results when compared to controls.…”

Section: Neurotrophin-3mentioning

confidence: 99%

See 1 more Smart Citation

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed.

show abstract

Structure Preservation of the Inner Ear in Cochlear Implantation

Crohan

Rajan

2022

Cochlear Implants

View full text Add to dashboard Cite

The effect of local application of insulin-like growth factor for prevention of inner-ear damage caused by electrode trauma

Abstract: Local insulin-like growth factor 1 application may protect hearing after cochlear implantation.

Cited by 3 publications

References 15 publications

The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study

The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study

Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

Structure Preservation of the Inner Ear in Cochlear Implantation

Contact Info

Product

Resources

About